Comparative virulence of <i>in vitro</i>‐cultured primate‐ and pig‐associated <i>Helicobacter suis</i> strains in a BALB/c mouse and a Mongolian gerbil model

Bosschem, Iris; Flahou, Bram; Bakker, Jaco; Heuvelman, Edwin; Langermans, Jan A. M.; Bruyne, Ellen De; Joosten, Myrthe; Smet, Annemieke; Ducatelle, Richard; Haesebrouck, Freddy

doi:10.1111/hel.12349

Cited by 10 publications

(20 citation statements)

References 27 publications

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“…In line with what Bosschem et al. showed for H. suis , Chonwerawong et al . found that the host background has a profound impact on the susceptibility to Helicobacter‐induced pathologies.…”

Section: Helicobacter Felis Infection Of Mice As a Model For Human Hsupporting

confidence: 76%

“…Recently, H. suis strains were isolated in vitro from the stomach of rhesus monkeys and crab‐eating macaques. Similar to pig‐associated H. suis strains, these primate‐associated H. suis strains were shown to induce severe gastric inflammation in mice and Mongolian gerbils, which was accompanied by a marked Th17 response and increased CXCL‐13 levels, which may play a role in the development of typical lymphoid lesions associated with H. suis infection . These same authors characterized, for the first time, the inflammation in the stomach of H. suis ‐infected pigs .…”

Section: Pathogenesis Of Non Helicobacter Pylori Helicobacter Infectionsmentioning

confidence: 88%

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Other Helicobacters, gastric and gut microbiota

et al. 2017

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The current article is a review of the most important and relevant literature published in 2016 and early 2017 on non-Helicobacter pylori Helicobacter infections in humans and animals, as well as interactions between H. pylori and the microbiota of the stomach and other organs. Some putative new Helicobacter species were identified in sea otters, wild boars, dogs, and mice. Many cases of Helicobacter fennelliae and Helicobacter cinaedi infection have been reported in humans, mostly in immunocompromised patients. Mouse models have been used frequently as a model to investigate human Helicobacter infection, although some studies have investigated the pathogenesis of Helicobacters in their natural host, as was the case for Helicobacter suis infection in pigs. Our understanding of both the gastric and gut microbiome has made progress and, in addition, interactions between H. pylori and the microbiome were demonstrated to go beyond the stomach. Some new approaches of preventing Helicobacter infection or its related pathologies were investigated and, in this respect, the probiotic properties of Saccharomyces, Lactobacillus and Bifidobacterium spp. were confirmed.

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Section: Helicobacter Felis Infection Of Mice As a Model For Human Hsupporting

confidence: 76%

Section: Pathogenesis Of Non Helicobacter Pylori Helicobacter Infectionsmentioning

confidence: 88%

Other Helicobacters, gastric and gut microbiota

et al. 2017

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“…21 In the mouse model, H2afz, PPIA, and HPRT were chosen for normalization, as they were the most stable reference genes as determined using GeNorm version 3.4. 21 In the mouse model, H2afz, PPIA, and HPRT were chosen for normalization, as they were the most stable reference genes as determined using GeNorm version 3.4.…”

Section: Quantitativereal-timepcrfortheanalysisof Cytokine/chemokinmentioning

confidence: 99%

Species‐specific immunity to Helicobacter suis

et al. 2017

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“…The H. suis isolation protocol, which has successfully been applied on porcine and non-human primate stomachs highly colonized with H. suis, 8 …”

Section: Isolation Of Porcine H Suis Strain From the Murine Stomacmentioning

confidence: 99%

“…Moreover, it cannot be excluded that infections with these agents sometimes remain asymptomatic or cause only mild symptoms which are not rigorously examined. [6][7][8] H. suis is transmitted to humans most likely through direct or indirect contact with pigs. 2,3 Helicobacter suis appears to be the most important among the NHPH.…”

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confidence: 99%