1987
DOI: 10.1097/00004872-198706000-00008
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Compared Effects of a Low and a High Sodium Diet on the Renal and Urinary Concentration and Activity of Kallikrein in Normal Rats

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Cited by 24 publications
(10 citation statements)
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“…In this respect, we previ ously demonstrated that excessive sodium ingestion for 6 days in the rat resulted in a decrease in renal tissue immunoreactive kallikrein content [12]. The suppressive effect of high salt intake has also been reported in other studies [1].…”
Section: Discussionsupporting
confidence: 70%
See 1 more Smart Citation
“…In this respect, we previ ously demonstrated that excessive sodium ingestion for 6 days in the rat resulted in a decrease in renal tissue immunoreactive kallikrein content [12]. The suppressive effect of high salt intake has also been reported in other studies [1].…”
Section: Discussionsupporting
confidence: 70%
“…It is generaly accepted that dietary sodium restriction increases urinary kallikrein excretion (UKE) [3,4], In contrast no general agreement exists regarding the effect of sodium load on the renal kallikrein kinin system. UKE has been variously reported as being decreased [5][6][7], unchanged [8,9] or increased [7,10,11], The duration and the protocol of sodium load could account for the discre pancy in the response of UKE [12]. A large variety of salt and water balance manipulations have been used to in vestigate the response of UKE to alterations in sodium and water metabolism.…”
Section: Introductionmentioning
confidence: 99%
“…In normal human subjects, intravenous water loading during prolonged sodium restriction produced a significant increase in kallikrein excretion, but not during the period of normal sodium intake (120). A low dietary sodium intake or sodium restriction has consistently been observed to increase urinary kallikrein excretion in humans (120 -123) and in rats (124,125). In micro-dissected segments of rabbit nephrons, low sodium intake markedly increases the levels of both active and inactive kallikreins in the granular portion of the distal convoluted tubules and in the cortical CD (or CNT) without altering either the distribution profile or the ratio of active-to total-kallikrein in the nephron or the urine.…”
Section: Stimuli For Kallikrein Secretion In the Kidney 1) Sodiummentioning
confidence: 99%
“…Long-term studies in the rat showed an increase in active kallikrein excretion with a low sodium diet and with 1% sodium in the drinking water (Bascands et al 1987) or a significant decrease in kallikrein excretion with 1% saline to drink .…”
Section: Biphasic Response To Angiotensinmentioning
confidence: 99%