Comparing Antibiotic Pastes with Electrospun Nanofibers as Modern Drug Delivery Systems for Regenerative Endodontics

Brimo, Nura; Serdaroğlu, Dilek Çökeliler; Uysal, Büşra

doi:10.2174/1567201819666211216140947

Cited by 30 publications

(5 citation statements)

References 107 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among them, biomedical applications hold the most promise. Particularly, the medical applications of different kinds of medical accessories and possible tissue engineering products are underway urgently [ 80 , 81 ]. The present hybrid films from a combination of electrospinning and casting should be candidates for them.…”

Section: Resultsmentioning

confidence: 99%

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

et al. 2022

View full text Add to dashboard Cite

One of the most important trends in developments in electrospinning is to combine itself with traditional materials production and transformation methods to take advantage of the unique properties of nanofibers. In this research, the single-fluid blending electrospinning process was combined with the casting film method to fabricate a medicated double-layer hybrid to provide a dual-phase drug controlled release profile, with ibuprofen (IBU) as a common model of a poorly water-soluble drug and ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) K60 as the polymeric excipients. Electrospun medicated IBU-PVP nanofibers (F7), casting IBU-EC films (F8) and the double-layer hybrid films (DHFs, F9) with one layer of electrospun nanofibers containing IBU and PVP and the other layer of casting films containing IBU, EC and PVP, were prepared successfully. The SEM assessments demonstrated that F7 were in linear morphologies without beads or spindles, F8 were solid films, and F9 were composed of one porous fibrous layer and one solid layer. XRD and FTIR results verified that both EC and PVP were compatible with IBU. In vitro dissolution tests indicated that F7 were able to provide a pulsatile IBU release, F8 offered a typical drug sustained release, whereas F9 were able to exhibit a dual-phase controlled release with 40.3 ± 5.1% in the first phase for a pulsatile manner and the residues were released in an extended manner in the second phase. The DHFs from a combination of electrospinning and the casting method pave a new way for developing novel functional materials.

show abstract

Section: Resultsmentioning

confidence: 99%

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Electrospinning technology has developed into multi-fluid electrospinning technology that is applied in many fields, such as drug delivery [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ] that is coaxial [ 25 , 26 , 27 ], modified coaxial [ 28 , 29 ], parallel [ 30 , 31 ], triaxial [ 32 , 33 ] and so on. The drug release rate can be controlled by adjusting the structure of nanofibers through multi-fluid electrospinning, which possesses certain advantages in the preparation process [ 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Zein/Polyoxyethylene Core-Sheath Ultrathin Fibers and Their Antibacterial Food Packaging Applications

et al. 2022

View full text Add to dashboard Cite

The purpose of this work is to develop a novel ultrathin fibrous membrane with a core-sheath structure as antibacterial food packaging film. Coaxial electrospinning was exploited to create the core-sheath structure, by which the delivery regulation of the active substance was achieved. Resveratrol (RE) and silver nanoparticles (AgNPs) were loaded into electrospun zein/polyethylene oxide ultrathin fibers to ensure a synergistic antibacterial performance. Under the assessments of a scanning electron microscope and transmission electron microscope, the ultrathin fiber was demonstrated to have a fine linear morphology, smooth surface and obvious core-sheath structure. X-ray diffraction and Fourier transform infrared analyses showed that RE and AgNPs coexisted in the ultrathin fibers and had good compatibility with the polymeric matrices. The water contact angle experiments were conducted to evaluate the hydrophilicity and hygroscopicity of the fibers. In vitro dissolution tests revealed that RE was released in a sustained manner. In the antibacterial experiments against Staphylococcus aureus and Escherichia coli, the diameters of the inhibition zone of the fiber were 8.89 ± 0.09 mm and 7.26 ± 0.10 mm, respectively. Finally, cherry tomatoes were selected as the packaging object and packed with fiber films. In a practical application, the fiber films effectively reduced the bacteria and decreased the quality loss of cherry tomatoes, thereby prolonging the fresh-keeping period of cherry tomatoes to 12 days. Following the protocols reported here, many new food packaging films can be similarly developed in the future.

show abstract

“…Furthermore, tendon damage is the most prevalent injury among people. Autografts have been regarded as the gold standard for anterior cruciate ligament (ACL) rupture restoration and tendon repair for several decades; however, allograft tissue is also widely used [102]. Tissue grafts have a high success rate; nevertheless, they have drawbacks.…”

Section: Regeneration Of Ligaments and Tendonsmentioning

confidence: 99%

A Review on the Electrospinning of Polymer Nanofibers and Its Biomedical Applications

Venmathi Maran,

Jeyachandran,

Kimura

2024

J. Compos. Sci.

View full text Add to dashboard Cite

Polymeric nanofibers have emerged as a captivating medium for crafting structures with biomedical applications. Spinning methods have garnered substantial attention in the context of medical applications and neural tissue engineering, ultimately leading to the production of polymer fibers. In comparison with polymer microfibers, polymer nanofibers boasting nanometer-scale diameters offer significantly larger surface areas, facilitating enhanced surface functionalization. Consequently, polymer nanofiber mats are presently undergoing rigorous evaluation for a myriad of applications, including filters, scaffolds for tissue engineering, protective equipment, reinforcement in composite materials, and sensors. This review offers an exhaustive overview of the latest advancements in polymer nanofiber processing and characterization. Additionally, it engages in a discourse regarding research challenges, forthcoming developments in polymer nanofiber production, and diverse polymer types and its applications. Electrospinning has been used to convert a broad range of polymers into nanoparticle nanofibers, and it may be the only approach with significant potential for industrial manufacturing. The basics of these spinning techniques, highlighting the biomedical uses as well as nanostructured fibers for drug delivery, disease modeling, regenerative medicine, tissue engineering, and bio-sensing have been explored.

show abstract

Comparing Antibiotic Pastes with Electrospun Nanofibers as Modern Drug Delivery Systems for Regenerative Endodontics

Cited by 30 publications

References 107 publications

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

Electrospun Zein/Polyoxyethylene Core-Sheath Ultrathin Fibers and Their Antibacterial Food Packaging Applications

A Review on the Electrospinning of Polymer Nanofibers and Its Biomedical Applications

Contact Info

Product

Resources

About