Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

Abstract

One of the most important trends in developments in electrospinning is to combine itself with traditional materials production and transformation methods to take advantage of the unique properties of nanofibers. In this research, the single-fluid blending electrospinning process was combined with the casting film method to fabricate a medicated double-layer hybrid to provide a dual-phase drug controlled release profile, with ibuprofen (IBU) as a common model of a poorly water-soluble drug and ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) K60 as the polymeric excipients. Electrospun medicated IBU-PVP nanofibers (F7), casting IBU-EC films (F8) and the double-layer hybrid films (DHFs, F9) with one layer of electrospun nanofibers containing IBU and PVP and the other layer of casting films containing IBU, EC and PVP, were prepared successfully. The SEM assessments demonstrated that F7 were in linear morphologies without beads or spindles, F8 were solid films, and F9 were composed of one porous fibrous layer and one solid layer. XRD and FTIR results verified that both EC and PVP were compatible with IBU. In vitro dissolution tests indicated that F7 were able to provide a pulsatile IBU release, F8 offered a typical drug sustained release, whereas F9 were able to exhibit a dual-phase controlled release with 40.3 ± 5.1% in the first phase for a pulsatile manner and the residues were released in an extended manner in the second phase. The DHFs from a combination of electrospinning and the casting method pave a new way for developing novel functional materials.

Electrospun Core (HPMC–Acetaminophen)–Shell (PVP–Sucralose) Nanohybrids for Rapid Drug Delivery

“…This is because these polymers often have fine biocompatibility, are non-toxic and have easy processability, and some of them are currently popular in traditional orodispersible tablets [ 81 , 82 ]. Certainly, the coaxial electrospinning, side-by-side electrospinning and also the single-fluid blending processes can be combined with traditional methods (such as casting films) for treating cellulose-based gels to offer sustained release and multiple-phase release profiles [ 83 , 84 , 85 ].…”

Electrospun nanofiber-based glucose sensors for glucose detection

“…The flexibility of the sheath solution is limited by its “spinnability.” Researchers have proposed an modified coaxial electrospinning, in which the sheath solution is non-spinnable, and the core solution is non-spinnable or spinnable ( Yu et al, 2010 ; Ning et al, 2021 ). The sheath solution overcame the limitation that it must be a spinnable solution, while expanding the range of the sheath solution, regulating the nanofiber diameter, and improving the quality of the fiber ( Liu et al, 2022e ; Liu et al, 2022f ). Ramon-Marquez et al (2017) prepared microfluidic devices by coaxial electrospinning for optical determination glucose.…”

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

“…Electrospinning differs from other spinning technologies, mainly in that the polymer solution or melt under the action of a high voltage electric field produces flow and deformation, generating a Taylor cone at the tip of the spinneret, and when the electric field strength is large enough to enable the droplets to overcome surface tension, a high-speed jet is generated, which is deposited on the receiving device to obtain fibers after a short distance electric field force of high speed stretching, solvent volatilization, and curing [ 34 , 35 , 36 ]. There are four main components in the electrospinning device, a high-voltage power supply that can generate up to 30 kV to higher voltages, a high-precision micro-pump with flow control, a nozzle, and an aluminum foil collector for fiber collection.…”