No abstract

Herein, novel multifunctionalized selenium nanoparticles have been rationally designed to reverse oxidative stress-induced spinal cord injury by attenuating ROS overproduction and mitochondria dysfunction via inactivation of p53 and MAPK pathways.

No abstract

Diabetes is a chronic, systemic metabolic disease that leads to multiple complications, even death. Meanwhile, the number of people with diabetes worldwide is increasing year by year. Sensors play an important role in the development of biomedical devices. The development of efficient, stable, and inexpensive glucose sensors for the continuous monitoring of blood glucose levels has received widespread attention because they can provide reliable data for diabetes prevention and diagnosis. Electrospun nanofibers are new kinds of functional nanocomposites that show incredible capabilities for high-level biosensing. This article reviews glucose sensors based on electrospun nanofibers. The principles of the glucose sensor, the types of glucose measurement, and the glucose detection methods are briefly discussed. The principle of electrospinning and its applications and advantages in glucose sensors are then introduced. This article provides a comprehensive summary of the applications and advantages of polymers and nanomaterials in electrospun nanofiber-based glucose sensors. The relevant applications and comparisons of enzymatic and non-enzymatic nanofiber-based glucose sensors are discussed in detail. The main advantages and disadvantages of glucose sensors based on electrospun nanofibers are evaluated, and some solutions are proposed. Finally, potential commercial development and improved methods for glucose sensors based on electrospinning nanofibers are discussed.

Early seedling development and emergence from the soil, which are critical for plant growth and important for crop production, are controlled by internal factors, such as phytohormones, and external factors, such as light and salt. However, little is known about how light and salt signals are integrated with endogenous cues in controlling plant physiological processes. Here, we show that overexpression of rice (Oryza sativa) PHYTOCHROME-INTERACTING FACTOR-LIKE14 (OsPIL14) or loss of function of the DELLA protein SLENDER RICE1 (SLR1) promotes mesocotyl and root growth, specifically in the dark and under salt stress. Furthermore, salt induces OsPIL14 turnover but enhances SLR1 accumulation. OsPIL14 directly binds to the promoter of cell elongation-related genes and regulates their expression. SLR1 physically interacts with OsPIL14 and negatively regulates its function. Our study reveals a mechanism by which the OsPIL14-SLR1 transcriptional module integrates light and gibberellin signals to fine-tune seedling growth under salt stress, enhancing understanding about how crops adapt to saline environments.