Electrospun Core (HPMC–Acetaminophen)–Shell (PVP–Sucralose) Nanohybrids for Rapid Drug Delivery

Abstract

The gels of cellulose and its derivatives have a broad and deep application in pharmaceutics; however, limited attention has been paid to the influences of other additives on the gelation processes and their functional performances. In this study, a new type of electrospun core–shell nanohybrid was fabricated using modified, coaxial electrospinning which contained composites of hydroxypropyl methyl cellulose (HPMC) and acetaminophen (AAP) in the core sections and composites of PVP and sucralose in the shell sections. A series of characterizations demonstrated that the core–shell hybrids had linear morphology with clear core–shell nanostructures, and AAP and sucralose distributed in the core and shell section in an amorphous state separately due to favorable secondary interactions such as hydrogen bonding. Compared with the electrospun HPMC–AAP nanocomposites from single-fluid electrospinning of the core fluid, the core–shell nanohybrids were able to promote the water absorbance and HMPC gelation formation processes, which, in turn, ensured a faster release of AAP for potential orodispersible drug delivery applications. The mechanisms of the drug released from these nanofibers were demonstrated to be a combination of erosion and diffusion mechanisms. The presented protocols pave a way to adjust the properties of electrospun, cellulose-based, fibrous gels for better functional applications.

Electrospun Zein/Polyoxyethylene Core-Sheath Ultrathin Fibers and Their Antibacterial Food Packaging Applications

“…Electrospinning technology has developed into multi-fluid electrospinning technology that is applied in many fields, such as drug delivery [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ] that is coaxial [ 25 , 26 , 27 ], modified coaxial [ 28 , 29 ], parallel [ 30 , 31 ], triaxial [ 32 , 33 ] and so on. The drug release rate can be controlled by adjusting the structure of nanofibers through multi-fluid electrospinning, which possesses certain advantages in the preparation process [ 34 , 35 , 36 ].…”

Electrospun Core–Sheath Nanofibers with Variable Shell Thickness for Modifying Curcumin Release to Achieve a Better Antibacterial Performance

“…Thus, increasing the distance between drugs and release medium outside fibers could theoretically prolong drug release. Core–sheath fibers are common and effective materials for sustained-release drugs, in which the unique sheath layer could provide a barrier to prevent drugs from leaching the core [ 75 , 76 , 77 ]. Fortunately, the sheath thickness can be manipulated by adjusting the flow rate of the middle working fluid in modified triaxial electrospinning, as shown in Figure 8 C. The thick sheath of core–sheath fibers indicated long diffusion distance for drug and water molecules, which determined the sustained drug delivery.…”

Electrospun nanofiber-based glucose sensors for glucose detection

“…The spinneret is the most innovative section in an electrospinning apparatus ( Wang M. et al, 2022 ; Liu et al, 2022b ). In the literature, the spinneret is relied on to determine what kinds of electrospinning processes are used; for example, a mono-axial spinneret leads to a single-fluid blending electrospinning, a concentric spinneret is used for a coaxial electrospinning, an eccentric spinneret is used for a side-by-side electrospinning process, and spinnerets with complicated structures are used for multiple-fluid processes ( Kang et al, 2022 ; Liu et al, 2022e ; Liu et al, 2022d ). Many sorts of collectors are used to randomly collect the nanofibers and aligning them into a certain order.…”