Comparing EQ-5D-3L and EQ-5D-5L in measuring the HRQoL burden of 4 health conditions in China

Weng, Guizhi; Hong, Yanming; Luo, Nan; Mukuria, Clara; Jiang, Jie; Yang, Zhihao; Li, Sha

doi:10.1007/s10198-022-01465-7

Cited by 13 publications

(14 citation statements)

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“…Other than the acceptability issue, WOOP showed good distributions and known-group validity results, suggesting a large proportion of individuals could understand these items and effectively use the response levels to respond. The response distributions of the WOOP did not show signs of ceiling effects and oor effects, which has been reported by other HRQoL measures like EQ-5D-5L and SF-6D [21,24]. A possible reason is WOOP used 'excellent' as the best response level and 'good' as the second response level for most items, but EQ-5D-5L used 'no problems' as the best response level.…”

Section: Discussionmentioning

confidence: 49%

“…Next, we examined the data distribution of all items to see whether ve response levels were all used. We checked whether ceiling effect [21] and oor effects were presented, i.e., items with over 70% of responses using level 1 (excellent) and level 5 (bad) suggesting ceiling effect and oor effect respectively [16]. On aggregate level, we also plotted histograms for both LSS and utility.…”

Section: Discussionmentioning

confidence: 99%

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Validating the Well-being of Older People (WOOP) instrument in China

Liu

Mao

Yang

2022

Preprint

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Introduction: So far, generic health related quality of life (HRQoL) has been used for estimating utility value, which then be used for calculating quality adjust life years (QALY). HRQoL measures may not capture many of the relevant and important aspects of quality of life other than health. Well-being of older people (WOOP) was first developed in the Netherlands to measure the well-being of older people; this study aims to validate this new measure in China. Methods: Between July and August 2022, a cross-sectional study was conducted in a convenient sample of 500 older people in Southwestern China. Consented older people reported their demographic information and the simplified Chinese version of WOOP measure using paper and pencil. The acceptability of WOOP was examined by percent of missing responses. Then, using the data without any missing responses, we examined the acceptability, item responses distributions, pairwise spearman correlations, exploratory factor analysis and known-group validity of WOOP. Results: Among the nine items, three of them had more than 10% of missing responses. The response distributions of 9 items in WOOP were overall good without signs of ceiling effects and floor effects. There was not high correlations among WOOP items. A two-factor EFA model suggested WOOP items can be categorized into either internal wellbeing or external wellbeing. Good known-group validity results were found reported. Discussion: Some WOOP items may not be easily understood by a small proportion of rural residents. Other results suggested WOOP to be valid instrument for measuring the well-being of elderly in China. The availability of WOOP enables the measurement of wellbeing related utility.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Validating the Well-being of Older People (WOOP) instrument in China

Liu

Mao

Yang

2022

Preprint

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“…For example, EQ-5D, which is the most commonly used MAUI 4 , includes five health-related dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) to describe health status 5 . EQ-5D, which includes both EQ-5D-3L and EQ-5D-5L, is commonly used in China to assess population health 6 , 7 and quantify disease burden 8 , 9 . With two additional response levels, EQ-5D-5L has demonstrated superior measurement properties compared to EQ-5D-3L worldwide 9 – 11 .…”

Section: Introductionmentioning

confidence: 99%

“…EQ-5D, which includes both EQ-5D-3L and EQ-5D-5L, is commonly used in China to assess population health 6 , 7 and quantify disease burden 8 , 9 . With two additional response levels, EQ-5D-5L has demonstrated superior measurement properties compared to EQ-5D-3L worldwide 9 – 11 . Moreover, EQ-5D is the recommended instrument for calculating health utility 4 , and the value sets for both versions of EQ-5D have been established in China 12 , 13 .…”

Section: Introductionmentioning

confidence: 99%

A head-to-head comparison of well-being of older people (WOOP) and EQ-5D-5L in patients, carers and general public in China

Ran

Mao

Yang

2023

Sci Rep

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Recently, well-being of older people measure (WOOP) was developed and validated in a Dutch population. Although WOOP was developed targeting the older people, it has the potential for use in a wider population. In this study, we aimed to examine the relationship between WOOP and EQ-5D-5L and compared their psychometric properties in a sample of patients, carers and healthy general public covering a wider age group. We conducted a cross-sectional study in Guizhou Province, China between July and August 2022. Data was collected using paper and pencil. We analysed and reported the acceptability, item response distribution, the Spearman correlation coefficients of all items, the Exploratory Factor Analysis (EFA) of all items, the known-group validity and the convergent validity of EQ-5D-5L utility and WOOP utility. A total of 322 participants completed the survey with 105 patients, 101 carers and 116 healthy general public. 9% of participants had at least one missing response. Three items of WOOP did not have any level 5 responses and EQ-5D-5L had more level 1 responses. The correlations were low between EQ-5D-5L and WOOP items and the three-factor EFA showed these two instruments had only one shared factor and the other two factors were only related to WOOP items. Younger people had lower missing response rate and a different response distribution for three items. WOOP measures a broader construct beyond health while EQ-5D-5L is a more sensitive instrument when health is considered alone. There is a potential of using WOOP in a wider population.

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“…As the most-used health-related quality of life (HRQoL) instrument worldwide including China, EQ-5D has been employed for varying purposes including monitoring population health [ 1 , 2 ], quantifying disease burden [ 3 , 4 ] and, most prominently, estimating health utility values for economic evaluation of health interventions and technologies [ 5 ]. For the purpose of estimating health utility values, EQ-5D value sets have been established in China [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Estimating an EQ-5D-Y-3L Value Set for China

et al. 2022

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Introduction The standard EQ-5D-Y-3L valuation protocol applies DCE data as the primary preference source to model the relative importance of dimensions while cTTO data served to anchor the DCE coefficients onto the QALY scale. This study aims to estimate an EQ-5D-Y-3L value set for China following this protocol, but with a larger cTTO design to better understand the role of cTTO data in estimating EQ-5D-Y-3L value sets. Methods In total, 150 choice sets and 28 EQ-5D-Y-3L health states were valued using DCE and cTTO methods with two independent samples, respectively. General public from 14 different regions were recruited using quota sampling method to achieve representativeness. We compared two modelling strategies: (1) fit the DCE data with mixed logit model with correlated coefficients and a subsequent mapping procedure for anchoring; (2) fit the DCE and TTO data jointly in a hybrid model. Two evaluation criteria (1) coefficient significance and monotonicity; (2) prediction accuracy of the observed cTTO values were used to select the value set. Results In total, 1476 individuals participated in the study, with 1058 participated the DCE interview and 418 participated the cTTO interview. The highest mean TTO value was 0.924 for state 11112 and the lowest mean TTO value was − 0.088 for state 33333. The hybrid model with an A3 term performed the best and was selected as the value set. Discussion Following the international protocol and using a larger cTTO design, this study established the EQ-5D-Y-3L value set using a hybrid model for China. Future EQ-5D-Y-3L valuation study could consider using a larger cTTO design for estimating the value set. Supplementary Information The online version contains supplementary material available at 10.1007/s40273-022-01216-9.

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Comparing EQ-5D-3L and EQ-5D-5L in measuring the HRQoL burden of 4 health conditions in China

Cited by 13 publications

References 37 publications

Validating the Well-being of Older People (WOOP) instrument in China

Validating the Well-being of Older People (WOOP) instrument in China

A head-to-head comparison of well-being of older people (WOOP) and EQ-5D-5L in patients, carers and general public in China

Estimating an EQ-5D-Y-3L Value Set for China

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