Comparing Hyperlipidemia Control with Daily Versus Twice-Weekly Simvastatin

Abstract

The twice-weekly regimen safely maintained most of the patients at their LDL-C goal level, and over half the patients found this regimen to be the same or easier to follow than a daily regimen. Large outcome studies evaluating this approach are needed.

Efficacy of alternate-day versus everyday dosing of atorvastatin

“…Studies evaluating the effect and tolerance of alternative statin dosing are limited. A limited number of trials have demonstrated efficacy with alternate-day statin dosing including a few anecdotal case reports,[14–17] but till date no such trials have been conducted in India. The study reported here examines the effect and tolerance of every other day atorvastatin therapy in comparison to the established daily statin regimen in reduction of plasma LDL-C.…”

Effects of the Polysaccharide from the Sporophyll of Brown Alga Undaria Pinnatifida on Serum Lipid Profile and Fat Tissue Accumulation in Rats Fed a High‐Fat Diet

“…Hyperlipidemia is an important risk factor leading to cardiovascular disease, which is a major cause of death in many countries and has arisen as a global health issue (Jain and others ). Because it was suggested that the appropriate control of the lipid levels in blood circulatory system might be a standard strategy to prevent cardiovascular disease (Mangin and others ), various anti‐hyperlipidemia agents, such as bile acid sequestrants (for example, cholestyramine), 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors (for example, statin), and fibric acid derivatives (for example, gemfibrozil) have been used. However, in some cases, the use of these agents has resulted in adverse effects such as hepatotoxicity, myopathy, or noncardiovascular death (Kashani and others ).…”