Effects of the Polysaccharide from the Sporophyll of Brown Alga Undaria Pinnatifida on Serum Lipid Profile and Fat Tissue Accumulation in Rats Fed a High‐Fat Diet

Abstract

We investigated the effects of the polysaccharide from the sporophyll of a selected brown alga Undaria pinnatifida on serum lipid profile, fat tissue accumulation, and gastrointestinal transit time in rats fed a high-fat diet. The algal polysaccharide (AP) was prepared by the treatment of multiple cellulase-producing fungi Trichoderma reesei and obtained from the sporophyll with a yield of 38.7% (dry basis). The AP was mostly composed of alginate and fucoidan (up to 89%) in a ratio of 3.75:1. The AP was added to the high-fat diet in concentrations of 0.6% and 1.7% and was given to male Sprague-Dawley rats (5-wk-old) for 5 wk. The 1.7% AP addition notably reduced body weight gain and fat tissue accumulation, and it improved the serum lipid profile, including triglycerides, total cholesterol, and very low-density lipoprotein-cholesterol. The effects were associated with increased feces weight and shortened gastrointestinal transit time. In addition, the lipid peroxidation of the liver was decreased in both groups.

Antimicrobial and Antibiofilm Activities of Sulfated Polysaccharides from Marine Algae against Dental Plaque Bacteria

“…On the basis of these ratios, the biomass of fucoidan in brown algae can be estimated to be ca. 8.0 to 10.1% (dry), but the average yield with the acid extraction method [ 19 , 20 ] employed in this study was comparatively low.…”

“…Two methods were employed for the isolation of crude sulfated polysaccharides according to algae classification based on pigments. For brown algae, the isolation was conducted according to the methods recommended by Koo et al and Kim et al [ 19 , 20 ]. Briefly, a 100 g sample of each algal powder was treated with 85% methanol for 2 h using a reflux system (at boiling point) and centrifuged at 7500× g for 15 min to remove lipid components and low-molecular-weight compounds.…”

Potential Usefulness of a Wakame/Carob Functional Snack for the Treatment of Several Aspects of Metabolic Syndrome: From In Vitro to In Vivo Studies

“…The major components of U. pinnatifida include carbohydrates, such as monosaccharides, polysaccharides (including sacran, mannan, and xylan), and dietary fiber; in lower proportion it contains lipids, proteins, vitamins, amino acids, and its derivatives, such as methacrylic acid and tauric acid, minerals, as well as some phytochemicals, including flavonoids, alkaloids, and sterols [12,13,14]. There are numerous animal studies that support its potential use against obesity, dyslipidemia, inflammation, and insulin resistance [15,16]. Results found by our group, also highlight the wakame (W), among other algae, for its anti-inflammatory, anti-hypertensive, and fat-lowering effects [17].…”

Health‐promoting effects of dietary polysaccharide extracted from Dendrobium aphyllum on mice colon, including microbiota and immune modulation

“…This indicates that DAP had a laxative effect in mice. Accumulation of faecal matter such as ammonia gas, increased the risk of colon cancer, inflammatory bowel disease and other colonic disorders, whereas dietary fibre, primarily polysaccharides, have been shown to reduce the gastrointestinal transit time because of the physical characteristics of the molecules (Hu et al ., ; Kim et al ., ). Two primary factors allow polysaccharides to show great influence on the laxation.…”