The COVID-19 epidemic is changing people's lives, so it is necessary to continuously update the design of the residence to adapt to the changing life. This study aims to investigate the impact of unit space layout factors in MURBs on residents' experiences during the COVID-19 pandemic. It also discusses the corresponding need for residential space renovations. Furthermore, this paper presents design adjustment recommendations for residents living in these constrained buildings and provides suggestions for future housing design to better meet the residents' housing needs. On the one hand, the layout of residential space should fully consider the use efficiency of space, with multi-functional and variable characteristics, so as to be suitable for different life cycles of the family. On the other hand, the spatial distance inside the house and the comfort of the environment should also be considered to help intergenerational communication, restore and improve the mental state of the residents, and promote the improvement of the quality of life of the residents.