Comparing the Anti-diabetic Effect of Sleeve Gastrectomy with Transit Bipartition Against Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Using a Diabetic Rodent Model

Liu, Pengpeng; Widjaja, Jason; Dolo, Ponnie Robertlee; Yao, Libin; Jiang, Hong; Shao, Yong; Zhu, Xiaoping

doi:10.1007/s11695-021-05256-6

Cited by 13 publications

(5 citation statements)

References 46 publications

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“…Furthermore, the HOMA-IR levels were found to be lower in RYGB than in the LSG. [19] Regarding the lipid profile, the levels of TG and LDL maintained their downward trend in all follow-ups. However, there was a significant difference among the groups in terms of the mean HDL in the 6th month; the mean HDL was 50.9 ± 10.5 mg/ dL in the LSG group, which was higher than that in the other groups.…”

Section: Discussionmentioning

confidence: 89%

Comparison of short- and long-term outcomes of bariatric surgery methods: A retrospective study

et al. 2022

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The present study is intended to retrospectively compare the short-and long-term outcomes of 3 different treatment methods in patients undergoing bariatric surgery and the variances in weight and nutritional parameters during the preoperative and postoperative periods. In this study, 534 patients who underwent laparoscopic sleeve gastrectomy (LSG), laparoscopic Roux-En-Y gastric bypass (LRYGB), and laparoscopic one anastomosis gastric bypass (LOAGB) between 2014 and 2021 were included. The sociodemographic and biodemographic characteristics of these patients, their weight losses and nutritional changes in the preoperative and postoperative periods, operative times, hospital stays, complications, and morbidity and mortality rates were retrospectively compared. There was a statistically significant difference between the surgical methods in the percentages of excess weight loss and total weight loss in the 1st and 3rd months. There were significant differences in the homeostasis model assessment of insulin resistance, folic acid, vitamin D, iron, ferritin, and parathyroid hormone levels (P < .05). All 3 techniques were found to be successful in facilitating weight loss at the end of the first year. LRYGB and LOAGB were found to be superior to LSG in terms of remission from diabetes during the first 6 months, whereas LSG was superior to the other methods in terms of nutritional deficiencies. Despite being more advantageous in terms of operative time, LSG and LOAGB were disadvantageous compared with the LRYGB technique because of the higher rates of leakage and mortality in the LSG technique and the higher rate of bile reflux in the LOAGB technique.

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Section: Discussionmentioning

confidence: 89%

Comparison of short- and long-term outcomes of bariatric surgery methods: A retrospective study

et al. 2022

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“…A 2 h OGTT and ITT were performed at 9 a.m. after overnight fasting before the operation and at 3 weeks postoperatively. The OGTT and ITT procedures were performed as described by Liu et al [ 15 ]. The OGTT was performed with the gavage of a 50% glucose solution (3 mg/kg dosage), and the ITT was performed by intraperitoneal injection of human insulin (0.5 IU/kg dosage).…”

Section: Methodsmentioning

confidence: 99%

Regulation of Pancreatic TXNIP‐Insulin Expression Levels after Bariatric Surgery Using Diabetic Rodent Model

Widjaja

Chu

Wang

et al. 2023

BioMed Research International

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Purpose. The purpose of this study was to investigate the effect of bariatric surgery on pancreatic thioredoxin-interacting protein (TXNIP) and insulin expression levels. The research question is does bariatric surgery induce changes in the pancreatic TXNIP level, given that TXNIP has been proposed as a key glucose control factor? Methods. Using nondiabetic and diabetic rats, we investigated whether our streptozotocin-induced diabetic rat models exhibited changes in pancreatic TXNIP regulation. Following this confirmation, we randomly divided the diabetic rats into the following three groups: the gastric bypass group ( n = 16 ), pair-fed group ( n = 10 ), and sham group ( n = 10 ). Preoperatively and 3 weeks postoperatively, all the rats underwent an oral glucose tolerance test, insulin tolerance test, and blood sampling procedures for hormonal analysis. Results. The TXNIP messenger ribonucleic acid (mRNA) and protein expression levels were significantly lower in the gastric bypass group than in the other groups. Regarding the gastric bypass group, the pancreatic mRNA expression levels of microRNA-204 (miR-204) and MafA were significantly lower and higher, respectively, than in the other groups. Furthermore, the levels of pancreatic insulin expression at the mRNA and protein levels were also significantly higher in the gastric bypass group than in the other groups. Conclusion. Bariatric surgery significantly improved glucose control and regulated the pancreatic insulin production pathways of TXNIP, miR-204, and MafA. The regulation of TXNIP, miR-204, and MafA might play an important role in the mechanism of diabetes remission following bariatric surgery.

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“…In the RYTB procedure (Fig. 5 a) 21 , a 20–30% gastric pouch was formed. The small intestine was transected at 40 cm from the ileocecal junction.…”

Section: Methodsmentioning

confidence: 99%

Comparison of three different anastomotic methods of sleeve gastrectomy with transit bipartition using an obese rodent model

Chu,

Widjaja,

Wang

et al. 2023

Sci Rep

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The long-term effects and safety of single-anastomosis sleeve ileal (SASI) bypass have not been confirmed. The one anastomosis procedure carries the risk of bile reflux, and Braun anastomosis has the capacity to reduce bile reflux. This study was designed to compare the influences of bile reflux and histological changes in the esogastric sections of rats. Obese Sprague–Dawley rats underwent sleeve gastrectomy with transit bipartition (RYTB) (n = 12), SASI (n = 12), SASI bypass with Braun anastomosis (BTB) (n = 12), esojejunostomy (EJ) (n = 12), and SHAM (n = 8) surgery. During the 12-week follow-up period, weight changes, glucose improvement, and changes in serum nutrition were evaluated. Histological expression and bile acid concentration in the rats in all groups were also evaluated. No significant differences in weight loss and glucose improvements were observed in the RYTB, SASI, and BTB groups. The RYTB and BTB groups had significantly lower bile acid concentration and albumin levels than the SASI group. In addition, mucosal height in the RYTB and BTB groups was significantly lower than in the SASI group. Braun anastomosis had a significant effect on anti-reflux. BTB may be a superior primary procedure due to its potential for parallel bariatric and metabolic improvements, effective anti-reflux effects, simplified operations, and avoidance of severe malnutrition. Further clinical studies are needed to confirm these findings.

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Comparing the Anti-diabetic Effect of Sleeve Gastrectomy with Transit Bipartition Against Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Using a Diabetic Rodent Model

Cited by 13 publications

References 46 publications

Comparison of short- and long-term outcomes of bariatric surgery methods: A retrospective study

Comparison of short- and long-term outcomes of bariatric surgery methods: A retrospective study

Regulation of Pancreatic TXNIP‐Insulin Expression Levels after Bariatric Surgery Using Diabetic Rodent Model

Comparison of three different anastomotic methods of sleeve gastrectomy with transit bipartition using an obese rodent model

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