Comparision of osteoconductivity of biologic and artificial synthetic hydroxyapatite in experimental mastoid obliteration

Jang, Chul Ho; Cho, Yong Beom; Choi, Choong Hyeok; Jang, Yoon Seok; Jung, Won‐Kyo; Lee, Jong Kook

doi:10.3109/00016489.2013.859397

Cited by 12 publications

(7 citation statements)

References 20 publications

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“…Together, our finding highlights the importance of intervention timing and the choice of bioactive molecules, the combination of which will provide insights in the design of precise modification strategies for tissue-engineered bone. Furthermore, considering the intervening fibrous layer between biomaterials and surrounding tissues as reported previously [ 70 ], enhancement of fibrotic inhibition could improve the integration of biomaterials to accelerate bone regeneration.…”

Section: Discussionmentioning

confidence: 84%

A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration

Guo

Liu

Zhang

et al. 2022

Bioactive Materials

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The osteogenic microenvironment of bone-repairing materials plays a key role in accelerating bone regeneration but remains incompletely defined, which significantly limits the application of such bioactive materials. Here, the transcriptional landscapes of different osteogenic microenvironments, including three-dimensional (3D) hydroxyapatite (HA) scaffolds and osteogenic medium (OM), for mesenchymal stromal cells (MSCs) in vitro were mapped at single-cell resolution. Our findings suggested that an osteogenic process reminiscent of endochondral ossification occurred in HA scaffolds through sequential activation of osteogenic-related signaling pathways, along with inflammation and angiogenesis, but inhibition of adipogenesis and fibrosis. Moreover, we revealed the mechanism during OM-mediated osteogenesis involves the ZBTB16 and WNT signaling pathways. Heterogeneity of MSCs was also demonstrated. In vitro ossification of LRRC75A + MSCs was shown to have better utilization of WNT-related ossification process, and PCDH10 + MSCs with superiority in hydroxyapatite-related osteogenic process. These findings provided further understanding of the cellular activity modulated by OM conditions and HA scaffolds, providing new insights for the improvement of osteogenic biomaterials. This atlas provides a blueprint for research on MSC heterogeneity and the osteogenic microenvironment of HA scaffolds and a database reference for the application of bioactive materials for bone regeneration.

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Section: Discussionmentioning

confidence: 84%

A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration

Guo

Liu

Zhang

et al. 2022

Bioactive Materials

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“…The traditional method is "Thermal calcination". The calcination method is used to make hydroxyapatite from natural sources or various biowastes such as fishbone, coral, bovine bone, egg shell, and sea shells 28 . Cuttlefish bones can be used as a natural resource for hydroxyapatite 29,30 .…”

Section: Chitosanmentioning

confidence: 99%

Marine based biomaterials: A Marvel in Periodontal Regeneration – A Review

JOHN¹,

SUGUNAN²,

ASWATHY³

et al. 2023

Advanced Dental Journal

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This article is intended to reach out to the readers about the potential of marine based bio materials in the field of periodontal regeneration. Periodontal Regeneration is the reproduction or reconstruction of a lost or injured tissue so that the architecture and function of lost or injured tissues are completely restored. Regeneration done using guided tissue regeneration procedures helps in guiding the regeneration of periodontal structures through differential tissue responses. Various types of barrier membranes or bone grafts used for regenerative procedures are autograft, allograft, xenograft and alloplast. Xenografts such as bovine, porcine had been used commonly in the regenerative procedures. Since the bovine derived collagen have higher risk of encephalopathy other sources of collagen have been researched upon. Besides mammalian collagen, it has been suggested that fish collagen have the potential that can be used in the development of GTR/GBR. In order to overcome the shortcomings in collagen and to improve the regenerative potential, researches are being made with the addition of various natural bioactive substances like chitosan and hydroxyapatite.

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“…These phenomena, allied to concomitant angiogenesis, lead to new bone formation during repair. Hydroxyapatite is the biomaterial of choice due to its high tissue compatibility and osteoconductivity [7,8]. Bone formation can be observed directly onto the hydroxyapatite surface without fibrous tissue interposition.…”

Section: Introductionmentioning

confidence: 99%

“…Radiological evaluation during clinical investigations of implanted hydroxyapatite and b-TCP in humans revealed satisfactory osteoconductive qualities for both materials [8,9]. Commercially available version of hydroxyapatite is able to induce bone repair in clinical settings [10,7].…”

Section: Introductionmentioning

confidence: 99%

Effects of chrondro-osseous regenerative compound associated with local treatments in the regeneration of bone defects around implants: an in vivo study

et al. 2015

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Comparision of osteoconductivity of biologic and artificial synthetic hydroxyapatite in experimental mastoid obliteration

Abstract: Neither BHA nor AHA exhibited signs of resorption until 12 weeks of obliteration. However, the accelerated osteoconductive bone formation in the BHA group was better than in the AHA group according to micro-CT and confocal microscopic findings.

Cited by 12 publications

References 20 publications

A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration

A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration

Marine based biomaterials: A Marvel in Periodontal Regeneration – A Review

Effects of chrondro-osseous regenerative compound associated with local treatments in the regeneration of bone defects around implants: an in vivo study

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