This paper designs, simulates, and analyzes the S-band microstrip patch antenna (MPA) for wireless applications. FR-4 (lossy) and Rogger RT/duroid, whose dielectric permittivity is 4.3 and 2.2, respectively, have been used as substrate materials. Simulation is done by computer simulation technology (CST) suite studio 2019 software. Simulations with FR-4 material showed that the return loss was -20.405 dB, the gain was 2.592 dB, the directivity was 7.47 dBi, the voltage standing wave ratio (VSWR) was 1.221, the bandwidth (BW) was 0.0746 GHz, and the efficiency was 34.69%. Also, Rogers RT/duroid material gives results of a return loss of -12.542 dB, a bandwidth (BW) of 0.0349 GHz, a gain of 8.092 dB, a directivity of 8.587 dBi, and an efficiency of 94.24%. The main goal of this antenna is to have a low return loss while getting as close as possible to a VSWR of 1. This will improve the antenna's gain, directivity, and efficiency compared to other antennas. Copper was used to make the patch and the ground, which were 0.35 mm and 0.0077 mm thick, respectively. The results obtained from the proposed antenna were better than those previously published in various in modern scientific journal and conference papers.