2022
DOI: 10.1186/s40658-022-00492-w
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Comparison between a dual-time-window protocol and other simplified protocols for dynamic total-body 18F-FDG PET imaging

Abstract: Purpose Efforts have been made both to avoid invasive blood sampling and to shorten the scan duration for dynamic positron emission tomography (PET) imaging. A total-body scanner, such as the uEXPLORER PET/CT, can relieve these challenges through the following features: First, the whole-body coverage allows for noninvasive input function from the aortic arteries; second, with a dramatic increase in sensitivity, image quality can still be maintained at a high level even with a shorter scan durat… Show more

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Cited by 16 publications
(9 citation statements)
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“…Advanced algorithms have also been written to reduce the long dynamic scan time without sacrificing acquired information. Wang et al [30] explored the feasibility of a dual-time-window protocol for 18 F-FDG imaging on an uEXPLORER scanner. The protocol involved a 10-min duration scan immediately postinjection followed by a 5-min scan at 1 h post-injection, and showed good consistency with the reference quantification, minimal bias, and consistent parametric images.…”
Section: Dynamic Scan Protocolmentioning
confidence: 99%
“…Advanced algorithms have also been written to reduce the long dynamic scan time without sacrificing acquired information. Wang et al [30] explored the feasibility of a dual-time-window protocol for 18 F-FDG imaging on an uEXPLORER scanner. The protocol involved a 10-min duration scan immediately postinjection followed by a 5-min scan at 1 h post-injection, and showed good consistency with the reference quantification, minimal bias, and consistent parametric images.…”
Section: Dynamic Scan Protocolmentioning
confidence: 99%
“…To the best of our knowledge, this study is the first one to conduct a head-to-head comparison of FDG dynamic and delayed imaging for oncologic applications. Total-body scanner was known to have ultra-high sensitivity that can provide better image quality than conventional PET/CT scanner [ 24 , 29 , 32 , 33 ]. In addition, dynamic PET imaging was previously restricted to single-bed positions and time-consuming invasive blood sampling.…”
Section: Discussionmentioning
confidence: 99%
“…K i image was transformed to an MRFDG image (µmoL/g/min) by multiplying the blood glucose levels measured before the scan. IDIF was extracted from the ascending aorta by drawing a 10-mm-diameter region-of-interest (ROI) on six consecutive slices in an image obtained by summing early frames (0–60 s [ 29 ]). The delay (arrival time) between the body tissue and the aorta was computed using the leading-edge method [ 30 ].…”
Section: Methodsmentioning
confidence: 99%
“…The recent efforts were made to reduce the scanning time while allowing the parametric images to be drawn [17,19,20,[35][36][37][38]. As the proposed model predicts the entire frames of the dynamic PET given a few early frames alone, it provides the solution to reduce the scanning time while deriving the pharmacokinetics of interest in brain studies such as perfusion or binding perfusion.…”
Section: ) Reduced Time Protocolmentioning
confidence: 99%