Comparison between acute oral/respiratory and chronic stomatitis/gingivitis isolates of feline calicivirus: pathogenicity, antigenic profile and cross-neutralisation studies

Poulet, Hervé; Brunet, S.; Soulier, M.; Leroy, Vincent; Goutebroze, Sylvain; Chappuis, G.

doi:10.1007/s007050050021

Cited by 55 publications

(38 citation statements)

References 41 publications

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“…A 4.5-year-old male cat, diagnosed with FIV, exhibiting gingivitis, peridontitis and dental plaques; leucocytosis was also found (Cave et al 2012). Feline calicivirus causes oral vesicular disease and chronic stomatitis (Poulet et al 2000). In our study, ptyalism incidence increased with the severity of the oral disorders.…”

Section: Discussionsupporting

confidence: 51%

Prevalence of systemic disorders in cats with oral lesions

Dokuzeylül¹,

Kayar²,

Or³

2016

Vet. Med. - Czech

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Oral disorders of small animals constitute a problem for veterinarians. Chronic oral infections are commonly seen in domestic cats. The objectives of this study were to characterise feline oral lesions, common feline dental problems, and especially the association of oral disease and systemic disease in cats. Two hundred and twenty cats referred over a period of 33 months to the Internal Medicine Department of our University with signs of oral disorders were included in this prospective study and were examined for the occurrence of the most commonly seen diseases. Infectious diseases which frequently cause ulcers and/or erosions within the mouth and on the tongue, constituted a significant proportion of the cases identified in this study. Feline Coronavirus (FCoV) infection was diagnosed in 36 cats (16%), Feline Calicivirus (FCV) in 17 cats (8%) and 16 cats (7%) had three viral infections (FCoV + Feline Immunodeficiency Virus (FIV) + Feline Leukemia Virus (FeLV)) at the same time. We conclude that oral disorders may be a sign of underlying systemic diseases in cats, especially in those diagnosed with feline viral infections. Other diagnosed diseases included immune-mediated disorders, eosinophilic granuloma complex, gastrointestinal system disorders, nutritional disorders, diabetes mellitus, hepatic disorders and chronic renal failure. Therefore, the first step in preventing oral disease in animals must be routine physical examination which includes a comprehensive oral exam.

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Section: Discussionsupporting

confidence: 51%

Prevalence of systemic disorders in cats with oral lesions

Dokuzeylül¹,

Kayar²,

Or³

2016

Vet. Med. - Czech

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“…In some studies, approximately 80% of cats with LPGS have been shedding FCV compared to 20% of controls [52,59,109]. Although acute faucitis has been reproduced experimentally [91], the chronic disease has not been induced in experimental cats [53,79]. It is therefore likely that factors not associated with FCV, including other pathogens [52,322 A.D. Radford et al 59,116] and host factors [37], may also play a role in this complex and serious syndrome.…”

Section: Clinical Signsmentioning

confidence: 99%

“…Those based on sequencing and monoclonal antibodies have failed to identify consistent differences [31,33,65]. However, those based on polyclonal antisera reactivity have shown some differences between those isolates associated with chronic stomatitis and those associated with other diseases, which has been attributed to evolution of these FCV isolates in such chronically infected cats [19,79].…”

Section: Clinical Signsmentioning

confidence: 99%

Feline calicivirus

et al. 2007

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-Feline calicivirus (FCV) is an important and highly prevalent pathogen of cats. It belongs to the family Caliciviridae which includes other significant pathogens of man and animals. As an RNA virus, high polymerase error rates convey upon FCV a high genome plasticity, and allow the virus to respond rapidly to environmental selection pressures. This makes the virus very adaptable and has important implications for clinical disease and its control. Being genetically diverse, FCV is associated with a range of clinical syndromes from inapparent infections to relatively mild oral and upper respiratory tract disease with or without acute lameness. More recently, highly virulent forms of the virus have emerged associated with a systemic infection that is frequently fatal. A proportion of FCV infected cats that recover from acute disease, remain persistently infected. In such cats, virus evolution is believed to help the virus to evade the host immune response. Such longterm carriers may only represent a minority of the feline population but are likely to be crucial to the epidemiology of the virus. Vaccination against FCV has been available for many years and has effectively reduced the incidence of clinical disease. However, the vaccines do not prevent infection and vaccinated cats can still become persistently infected. In addition, FCV strain variability means that not all strains are protected against equally. Much progress has been made in understanding the biology and pathogenesis of this important feline virus. Challenges for the future will necessarily focus on how to control the variability of this virus particularly in relation to emerging virulent strains and vaccination.

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“…One reason for the ineffectiveness of FCV vaccination appears to be due to antigenic mismatch between vaccine viruses and the actual FCVs spreading in the field. That the antigenic properties of FCVs vary widely [20,21] and that most vaccines developed so far, both inactivated and modified live vaccines, consist of a single production virus is consistent with this. Thus, we developed a new feline trivalent inactivated vaccine, Kyoto Biken Feline-CPR, containing three FCV strains.…”

mentioning

confidence: 53%

Immunological and Genetic Characterization of Feline Caliciviruses Used in the Development of a New Trivalent Inactivated Vaccine in Japan

Masubuchi

Wakatsuki

Iwamoto

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. Although vaccination against feline calicivirus (FCV) infection is widespread in Japan, FCV-associated diseases are still a significant problem in cats. Thus, we developed a new trivalent inactivated vaccine, Kyoto Biken Feline-CPR, consisting of three FCV strains; one was the production strain of our previous vaccine, and the others were screened from 60 field isolates obtained between 1998 and 2000 based on cross-neutralization tests. In this report, the three FCV strains used for development of the new vaccine were antigenically and genetically characterized. The three strains were antigenically quite different, as revealed by cross-neutralization tests. Alignment of deduced amino acid sequences of capsid regions A to E revealed that there were marked differences between the strains in both the N-and C ends of region E. Antisera against the three vaccine strains, our new vaccine and 2 commercial vaccines were then evaluated for neutralization with 58 field isolates collected between 2003 and 2006. Rat antisera against the three vaccine strains and a mixture of the 3 strains neutralized 49, 37, 42 and 55 isolates, respectively. Cat antiserum against the new vaccine neutralized 50 (86.2%) isolates, whereas the numbers neutralized by cat antisera against 2 commercial vaccines were 37 (63.8%) and 25 (43.1%). In conclusion, the immunological and genetic properties of the 3 vaccine strains investigated varied widely, and the Kyoto Biken Feline-CPR vaccine may have more potential to meet the antigenic diversity of FCVs spreading throughout Japan.KEY WORDS: feline calicivirus, neutralization, vaccine.

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Comparison between acute oral/respiratory and chronic stomatitis/gingivitis isolates of feline calicivirus: pathogenicity, antigenic profile and cross-neutralisation studies

Cited by 55 publications

References 41 publications

Prevalence of systemic disorders in cats with oral lesions

Prevalence of systemic disorders in cats with oral lesions

Feline calicivirus

Immunological and Genetic Characterization of Feline Caliciviruses Used in the Development of a New Trivalent Inactivated Vaccine in Japan

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