Comparison Between Dexamethasone and Ibuprofen for Postoperative Pain Prevention and Control After Surgical Implant Placement: A Double‐Masked, Parallel‐Group, Placebo‐Controlled Randomized Clinical Trial

Bahammam, Maha A.; Kayal, Rayyan A.; Alasmari, Dhafer; Attia, Mai S.; Bahammam, Laila; Hassan, Mona Hassan Ahmed; Alzoman, Hamad; Almas, Khalid; Steffens, João Paulo

doi:10.1902/jop.2016.160353

Cited by 21 publications

(47 citation statements)

References 33 publications

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“…The following were excluded: pregnant or lactating women, use of some type of medication that could affect the perception of pain, history of allergy or intolerance to the drugs (ibuprofen and paracetamol) used in the research; and history of alcohol or drug abuse. -Sample Calculation Using statistical power analysis software R (software, R Foundation, Vienna, Austria), it was determined that 25 patients per group would be required to achieve 80% of power at 95% of confidence interval (CI), assuming moderate to intense changes in pain score 24 hours after surgery in at least one group and non-normal distribution data (16). In order to compensate for possible data loss during the study, the number of individuals allocated per group was increased by 10%, with 27 patients per group.…”

Section: Methodsmentioning

confidence: 99%

“…Three classes of analgesic drugs [blockages with local anesthetics, non-steroidal anti-inflammatory drugs (NSAIDs) and opioids] have been used for this purpose alone or in combination (5,6). Several studies have been conducted in PA, particularly in third molar extraction surgeries (7-12,) periodontal surgeries (13)(14)(15), and few studies in implant dentistry (1,(16)(17)(18), with conflicting results. In addition, different types of drugs have been tested in PA (1,9,(13)(14)(15)(16) however without a consensual definition of the best protocol regarding the drug, posology and period of exposure to the drug.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have been conducted in PA, particularly in third molar extraction surgeries (7-12,) periodontal surgeries (13)(14)(15), and few studies in implant dentistry (1,(16)(17)(18), with conflicting results. In addition, different types of drugs have been tested in PA (1,9,(13)(14)(15)(16) however without a consensual definition of the best protocol regarding the drug, posology and period of exposure to the drug. Studies have shown a high preference for the use of Ibuprofen in pain control related to dental problems or dental procedures (12,16,19) Ibuprofen, a name derived from the initials of isobutylphenyl propionic acid, is a drug in the group of NSAIDs which acts by non-selectively inhibiting cyclooxygenase 1 and 2 thus avoiding the consequent formation of pro-inflammatory mediators by the arachidonic acid cascade (19).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, different types of drugs have been tested in PA (1,9,(13)(14)(15)(16) however without a consensual definition of the best protocol regarding the drug, posology and period of exposure to the drug. Studies have shown a high preference for the use of Ibuprofen in pain control related to dental problems or dental procedures (12,16,19) Ibuprofen, a name derived from the initials of isobutylphenyl propionic acid, is a drug in the group of NSAIDs which acts by non-selectively inhibiting cyclooxygenase 1 and 2 thus avoiding the consequent formation of pro-inflammatory mediators by the arachidonic acid cascade (19). In this sense, the hypothesis for this study was that individuals who receive PA with the use of ibuprofen (600 mg, oral) 1 hour before the implant surgery present lower postoperative pain in relation to individuals receiving placebo medication.…”

Section: Introductionmentioning

confidence: 99%

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Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

Pereira¹,

Cota²,

Lima³

et al. 2020

J Clin Exp Dent

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Background: Preemptive analgesia has as its basic principle the administration of analgesics before the onset of painful stimuli, in order to reduce or prevent postoperative pain, but this question is little explored in implantology. Thus, this study was conducted in order to evaluate the clinical efficacy of ibuprofen in pain prevention after unit implant surgery. Material and Methods: For this triple-blind, parallel, placebo-controlled and randomized clinical trial, 54 insertion surgeries of unitary implants were performed. Two groups have received two different protocols 1 hour before surgery: Ibuprofen group (IBU) 600 mg of ibuprofen; and (2) placebo group (maize starch). The intensity of the pain was evaluated through the visual analogue scale (VAS) in 6 times (1, 6, 12, 24, 48 and 72 hours after the surgery). Patients were instructed to take 750 mg of paracetamol as rescue medication, if necessary. The occurrence and the intensity of pain were analyzed by means of an analysis of variance ANOVA with repeated measurements using the general linear model procedure. Results: The IBU group had significantly lower VAS scores overall (IBU = 0.30, ± 0.57; placebo = 1.14, ± 1.07; p<0.001) and at all times in the intra, intergroup comparisons and time/group interaction than the placebo group (p< 0.001). The use of rescue medication was significantly lower and the postoperative time was longer in the IBU group compared to placebo (p = 0.002). Conclusions: The single use of ibuprofen was found to be significantly superior in reducing pain after unit implant surgery compared to placebo.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

Pereira¹,

Cota²,

Lima³

et al. 2020

J Clin Exp Dent

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“…Dexamethasone has been reported to inhibit peripheral phospholipase, which decreases the pain-aggravating agents from the cyclooxygenase and lipoxygenase pathways. [7] Previous studies have shown the analgesic effect of dexamethasone in general and orthopedic surgery. In addition, preoperative administration of dexamethasone has been reported to reduce postoperative nausea and vomiting.…”

Section: Introductionmentioning

confidence: 99%

The efficiency and safety of dexamethasone for pain control in total joint arthroplasty

Ji¹,

2017

Medicine

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Background:This meta-analysis aimed to evaluate the efficiency and safety of dexamethasone administration in total knee and hip arthroplasties.Methods:Two researchers search the relevant studies independently including Embase (1980–017.04), PubMed (1966–017.04), ScienceDirect (1985–017.04), Web of Science (1950–2017.03), and Cochrane Library for potential relevant studies. After testing for heterogeneity between studies, data were aggregated for random-effects models when necessary. The results of dichotomous outcomes were expressed as risk difference (RD) with a 95% confidence intervals (CIs). For continuous various outcomes, mean difference (MD) or standard mean difference (SMD) with a 95% confidence intervals (CIs) was applied for assessment. Meta-analysis was performed using Stata 11.0 software.Results:Four randomized controlled trials (RCTs) including 361 patients met the inclusion criteria. The present meta-analysis indicated that there were significant differences between groups in terms of visual analogue scale (VAS) score at 12 hours (SMD = −0.579, 95% CI: −0.780 to −0.357, P = .000), 24 hours (SMD = −0.820, 95% CI: −1.036 to −0.604, P = .000), and 48 hours (SMD = −0.661, 95% CI: −1.149 to −0.172, P = .008). Dexamethasone was associated with a lower opioid consumption at 12 hours (SMD = −0.245, 95% CI: −0.465 to −0.025, P = .029), 24 hours (SMD = −0.285, 95% CI: −0.505 to −0.064, P = .011), and 48 hours (SMD = −0.989, 95% CI: −1.710 to −0.267, P = .007).Conclusion:Dexamethasone could significantly reduce postoperative pain scores and opioid consumption within the 1st 48 hours following total joint arthroplasty (TJA). The overall evidence quality was moderate to low, further high-quality RCTs are needed to identify the optimal dose of dexamethasone for reducing pain after TJA.

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Ibuprofen for acute postoperative pain in children

Pessano,

Gloeck,

Tancredi

et al. 2024

Cochrane Database of Systematic Reviews

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Comparison Between Dexamethasone and Ibuprofen for Postoperative Pain Prevention and Control After Surgical Implant Placement: A Double‐Masked, Parallel‐Group, Placebo‐Controlled Randomized Clinical Trial

Abstract: Steroidal dexamethasone is as effective as non-steroidal ibuprofen for preventing or controlling postoperative pain and discomfort after surgical implant placement.

Cited by 21 publications

References 33 publications

Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

The efficiency and safety of dexamethasone for pain control in total joint arthroplasty

Ibuprofen for acute postoperative pain in children

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