Comparison between Different Combinations of Alendronate, Platelet-rich Fibrin, Hydroxyapatite in Bone Regeneration in Endodontic Surgeries Using Cone-beam Computed Tomography

Singh, Anshdeep; Shah, Amit; Raman, Nikita; Ramola, Vikas; Gupta, Phalguni; Gupta, Somesh

doi:10.5005/jp-journals-10024-3312

The Journal of Contemporary Dental Practice

2022

DOI: 10.5005/jp-journals-10024-3312

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Comparison between Different Combinations of Alendronate, Platelet-rich Fibrin, Hydroxyapatite in Bone Regeneration in Endodontic Surgeries Using Cone-beam Computed Tomography

Anshdeep Singh¹,

Amit Shah²,

Nikita Raman³

et al.

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2024

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Cited by 2 publications

References 26 publications

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Exploring the potential of hydroxyapatite-based materials in biomedicine: A comprehensive review

Liu,

Xu,

Wang

et al. 2024

Materials Science and Engineering: R: Reports

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Exploring the potential of hydroxyapatite-based materials in biomedicine: A comprehensive review

Liu,

Xu,

Wang

et al. 2024

Materials Science and Engineering: R: Reports

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Platelet-rich Fibrin: A Systematic Review of Its Action

Zuleika,

Saleh,

Murti

et al. 2024

Journal of Nature and Science of Medicine

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Purpose:We aim to conduct a literature review on actions of platelet-rich fibrin (PRF), preclinical studies in PRF utility, and its potential uses in clinical settings.Methods:We conducted a literature review based on primary studies conducted on PubMed and Europe PMC between 2012 and 2022. We included 42 articles in this review from the results of our search.Results:Epithelial tissues act as a barrier from mechanical, chemical, and temperature damage. Naturally, hemostasis acts to reduce blood loss and creates initial fibrin matrices after traumatic events or injuries. PRF is a second-generation platelet concentrate, commonly made in the form of leukocyte and PRF due to leukocyte content. Fibrin matrices in PRF allow more sustained growth factors release when compared to PRP, the first-generation platelet concentrate. PRF comes from increased proliferation and differentiation mediated by reduced proliferation of inflammatory cells and sustained release of growth factors and cytokines.Conclusions:PRF action comes from increased proliferation and differentiation from growth factors and cytokines. PRF may reduce inflammation and fibrosis to improve soft-tissue and bone healing and allow for better graft integration.

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Comparison between Different Combinations of Alendronate, Platelet-rich Fibrin, Hydroxyapatite in Bone Regeneration in Endodontic Surgeries Using Cone-beam Computed Tomography

Cited by 2 publications

References 26 publications

Exploring the potential of hydroxyapatite-based materials in biomedicine: A comprehensive review

Exploring the potential of hydroxyapatite-based materials in biomedicine: A comprehensive review

Platelet-rich Fibrin: A Systematic Review of Its Action

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