Comparison between effects of intravenous lidocaine and sublingual nifedipine on preventing blood pressure increase in laryngoscopy

Abstract

Arrhythmia during surgery most frequently occurs during laryngoscopy and intratracheal intubation. Many surgical procedures require intratracheal intubation, which results in hemodynamic changes. These changes in ill patients and patients with limited coronary flow reserve are associated with serious events. Materials and methods: A randomized clinical trial was performed on 124 healthy patients who were elective surgery candidates at Taleghani hospital in Kermanshah. Patients were allocated randomly to each equal group of 62 patients with 95% significance and 90% power of test-retest for sample size. The patients had no history of disease or use of special medications. Drugs commonly used for laryngoscopy and intubation to prevent hemodynamic complications, intravenous lidocaine and sublingual nifedipine, were compared with independent and paired t-tests. Results: This comparison suggested that while the mean age, weight, and sex distribution in our two groups were the same, mean changes in systolic and diastolic blood pressure and heart rate increases in the lidocaine group were 12.6%, 7.5%, and 16.5%, and in the nifedipine group, 17.7%, 11.0%, and 23.5% (P value = 0.0052, 0.189, and 0.0001), respectively. Conclusion: According to the results of our study, intravenous lidocaine is more effective than sublingual nifedipine for preventing hemodynamic changes while performing laryngoscopy or intratracheal intubation.

Perbedaan Tekanan Darah, Laju Jantung dan Rate Pressure Product (RPP) Pada Pemberian Lidokain 1,5 Mg/Kgbb Intravena Sebelum Intubasi Dibandingkan Pemasangan Laryngeal Mask Airway (LMA)

“…13 Penelitian yang dilakukan oleh Mohzeni dkk menyatakan bahwa pemberian lidokain 1,5 mg/kgBB sebelum laringoskopi dan intubasi lebih efektif mencegah perubahan hemodinamik dibandingkan pemberian nifedipin sublingual. 9 Sukron dkk menyatakan pemberian lidokain 1,5 mg/kgBB intravena sebelum tindakan laringoskopi dan intubasi dapat mengurangi gejolak kardiovaskuler. 14…”

“…Pencegahan perubahan hemodinamik pada saat laringoskopi dan intubasi dapat membantu menghindari iskemia. 9 Berbagai penelitian dilakukan untuk mengetahui metode pencegahan gejolak hemodinamik pada saat laringoskopi dan intubasi. Diantaranya yaitu penggunaan berbagai teknik intubasi, pemilihan peralatan jalan nafas serta penambahan obat sebelum intubasi menggunakan…”