Comparison between electronic cigarette refill liquid and nicotine on metabolic parameters in rats

Golli, Nargès El; Dkhili, Houssem; Dallagi, Yosra; Rahali, Dalila; Lasram, Montassar; Bini-Dhouib, Ines; Lebret, Maryline; Rosa, Jean‐Philippe; Fazâa, Saloua El; Asmi, Monia Allal-El

doi:10.1016/j.lfs.2015.12.049

Cited by 46 publications

(43 citation statements)

References 32 publications

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“…2g). These results agree with those reported by recent literature studies 18 showing increased concentrations of TG, VLDL and TG/HDL ratios after four weeks’ intraperitoneal injection of nicotine and e-cig refill liquid containing nicotine in rats. Since the liver is the main organ responsible for cholesterol and lipoprotein synthesis, exposure to e-cig vapours might have affected rat liver function.…”

Section: Resultssupporting

confidence: 93%

E-cigarettes induce toxicological effects that can raise the cancer risk

Canistro

Vivarelli

Cirillo

et al. 2017

Sci Rep

155

129

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Electronic cigarettes (e-cigs) are devices designed to deliver nicotine in a vaping solution rather than smoke and without tobacco combustion. Perceived as a safer alternative to conventional cigarettes, e-cigs are aggressively marketed as lifestyle-choice consumables, thanks to few restrictions and a lack of regulatory guidelines. E-cigs have also gained popularity among never-smokers and teenagers, becoming an emergent public health issue. Despite the burgeoning worldwide consumption of e-cigs, their safety remains largely unproven and it is unknown whether these devices cause in vivo toxicological effects that could contribute to cancer. Here we demonstrate the co-mutagenic and cancer-initiating effects of e-cig vapour in a rat lung model. We found that e-cigs have a powerful booster effect on phase-I carcinogen-bioactivating enzymes, including activators of polycyclic aromatic hydrocarbons (PAHs), and increase oxygen free radical production and DNA oxidation to 8-hydroxy-2′-deoxyguanosine. Furthermore, we found that e-cigs damage DNA not only at chromosomal level in peripheral blood, such as strand breaks in leucocytes and micronuclei formation in reticulocytes, but also at gene level such as point mutations in urine. Our results demonstrate that exposure to e-cigs could endanger human health, particularly among younger more vulnerable consumers.

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Section: Resultssupporting

confidence: 93%

E-cigarettes induce toxicological effects that can raise the cancer risk

Canistro

Vivarelli

Cirillo

et al. 2017

Sci Rep

155

129

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“…Based on data of World Health Organization (WHO), in 2013 the number of death reach 6 million in the world as the results of smoking (Golli et al, 2016). The cigarette smoke contain more than 4.000 chemicals and hundreds of them were toxic substances for body.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Red Fruit Oil (Pandanus conoideus) to the Histophysiology of Rat (Rattus norvegicus) Liver Exposed to Cigarette Smoke

2018

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Free radicals in cigarette smoke may interfere the balanced of body molecules and cause the damage of hepatic cells. This issues may be prevented by using red fruit oil (Pandanus conoideus L) due to its antioxidant content. This study aimed to evaluate the structure and physiological conditions of liver when the red fruit oil given to the rat that exposed by cigarette smoke. This study carried out for 35 days with female white rats as the sample. The samples were 20 female white rats divided into four groups: P0 (negative control), P1 (positive control), P2 (exposed by cigarette smoke with administration of red fruit oil 0,1 ml/BB), P3 (exposed by cigarette smoke with administration of red fruit oil 0,2 ml/weight). The data of ALT, AST, cell diameter, and hepatic weight were analyzed by using analysis of variants (ANOVA). The results showed that administration of red fruit oil containing antioxidants can reduce levels of ALT, AST, hepatocyte diameter, and increase liver weight, although the difference is not significant compared to the control group and does not affect the eating and drinking behavior so as not to affect the body's metabolism. The conclusion of red fruit oil can reduce ALT, AST, hepatocyte diameter and increase hepatic weight due to exposure to cigarette smoke, although the difference is not significant to the control group, and does not affect the eating and drinking behavior, so good for consumption because it gives a beneficial effect on health liver organ. How to Cite

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Section: Effects Of Ecs On Metabolism and Developmentmentioning

confidence: 71%

“…In this study, total cholesterol (TC)/high density lipoproteins (HDL) and low density lipoproteins (LDL)/HDL levels went down (i.e., "bad" cholesterol) (El Golli et al 2016b). However, these rats also had hyperglycemia and an increase in transaminase activity indicating liver damage, regardless of the nicotine level (El Golli et al 2016b). Exposure of young mice to EC vapour resulted in less weight gain than a control, unrelated to nicotine, and less postnatal lung growth related to nicotine (McGrath-Morrow et al 2015).…”

Section: Effects Of Ecs On Metabolism and Developmentmentioning

confidence: 71%

Electronic cigarettes—A review of the physiological health effects

Zucchet

Schmaltz

2017

FACETS

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Electronic cigarettes (ECs) are devices that are used recreationally or as smoking cessation tools, and have become increasingly popular in recent years. We conducted a review of the available literature to determine the health effects caused by the use of these devices. A heating element in the EC aerosolizes a solution of propylene glycol, glycerol, nicotine (optional), and flavouring (optional). These compounds are generally harmless on their own. However, upon heating, they produce various carcinogens and irritants. We found that concentrations of these toxicants vary significantly depending on the type of EC device, the type of EC liquid, and the smoking behaviour of the user. Exposure to these vapours can cause inflammation and oxidative damage to in vitro and in vivo cells. EC aerosol can also potentially affect organ systems and especially cardiovascular and lung function. We concluded that EC use causes acute effects on health but not as severe as those of conventional cigarettes (CCs). These devices could, therefore, be of use for smokers of CCs wishing to quit. However, as EC aerosol introduces new toxicants not found in CCs, long-term studies are needed to investigate possible chronic effects associated with EC use.

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Comparison between electronic cigarette refill liquid and nicotine on metabolic parameters in rats

Cited by 46 publications

References 32 publications

E-cigarettes induce toxicological effects that can raise the cancer risk

E-cigarettes induce toxicological effects that can raise the cancer risk

The Effect of Red Fruit Oil (Pandanus conoideus) to the Histophysiology of Rat (Rattus norvegicus) Liver Exposed to Cigarette Smoke

Electronic cigarettes—A review of the physiological health effects

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