Comparison between filgrastim and lenograstim plus chemotherapy for mobilization of PBPCs

Comparison of Filgrastim and Lenograstim in Pediatric Solid Tumors

“…In vitro and in vivo studies showed that the morphology of neutrophils were altered when exposed to filgrastim, whereas the morphology of neutrophils was unchanged when exposed to lenograstim [17]. However, clinical studies failed to show superiority of one rG-CSF to another in the case of duration of neutropenia, FEN and length of hospitalization [18][19][20]. Consistently, our study could not detect any differences in these parameters.…”

Pharmacoeconomic analysis of the use of granulocyte colonystimulating factor drugs in prophylaxis of febrile neutropenia in cancer patients under healthcare settings in the Russian Federation

“…lenograstim and filgrastim is comparable, it was assumed to consider the efficacy of filgrastim and lenograstim being identical [41,42,49,50]. In addition, during the effectiveness analysis it was assumed that the effectiveness of the drugs of each International Non-proprietary Name (INN) was identical.…”

Peripheral Blood Progenitor Cells Mobilization in Patients with Multiple Myeloma

“…Our group has investigated the role of G-CSF glycosylation [72] that modifies the chemical and biological properties of G-CSF [73]. Our results show that cyclophosphamide in association with lenograstim results in more adequate mobilization, and the HSC collection target is reached more quickly and requires fewer leukaphereses in patients with MM, NHL or HL that are typical candidates for ASCT and for combined mobilization with chemotherapy and G-CSF.…”