Comparison between herbal medicine and fluoxetine for depression: A systematic review of randomized controlled trials

Ren, Yi; Zhu, Chenjun; Wu, Jianjun; Zheng, Ruwen; Cao, Huijaun

doi:10.1016/j.ctim.2015.07.002

Cited by 30 publications

(15 citation statements)

References 5 publications

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“…31 This result was consistent with previous systematic reviews of herbal medicine for depression. [95][96][97][98] Our review indicates that BC formula for depression is effective in the short term, similar to acute-phase treatment with antidepressants. 99,100 When BC formula was used as integrative medicine, the pooled results showed that it may reduce the severity of depression compared to SSRIs alone.…”

Section: Adverse Eventsmentioning

confidence: 93%

Managing Depression withBupleurum chinenseHerbal Formula: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Yang

Shergis

et al. 2020

The Journal of Alternative and Complementary Medicine

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Objectives: Bupleurum chinense (BC; Radix Bupleuri) formulae are widely used in herbal medicine clinical practice for major depressive disorder (MDD). This study provides an up-to-date and comprehensive systematic review and meta-analysis of BC formula for MDD. Design: Randomized controlled trials were retrieved from English and Chinese databases, from their inceptions to March 2019. Included studies compared BC formula alone or as integrative medicine to selective serotonin reuptake inhibitor (SSRI) antidepressants. Studies included adults 18-65 years of age. People with other types of depression or physical comorbidities, such as poststroke depression, bipolar, and other mental or physical disorders, were excluded. Meta-analysis was performed using STATA software. Grading of Recommendations Assessment, Development, and Evaluation was also conducted to assess the quality of evidence. Results: Thirty studies compared BC formula to antidepressants and 25 studies compared BC formula plus antidepressants to antidepressants alone. BC formula was more effective than antidepressants at improving depression severity measured on the Hamilton Rating Scale for Depression (HRSD) (standardized mean difference [SMD]-0.35, 95% confidence interval [CI]-0.52 to-0.18, I 2 = 81.2%). Integrative use of BC formula plus SSRIs was also superior to SSRIs alone at improving HRSD scores (SMD-1.03, 95% CI-1.43 to-0.62, I 2 = 94.2%). However, heterogeneity of the included studies was high and quality was low. The total number and severity of adverse events in the BC formula groups were less than that in the antidepressant groups. Conclusions: BC formula alone or given as integrative medicine with antidepressants reduced depression severity. However, the evidence is low quality and at risk of bias. Well-designed studies are needed to validate the results we identified in this review.

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Section: Adverse Eventsmentioning

confidence: 93%

Managing Depression withBupleurum chinenseHerbal Formula: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Yang

Shergis

et al. 2020

The Journal of Alternative and Complementary Medicine

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“…In most cases, positive drug control is more generally accepted and considered as a priority selection, whereas placebo control is less used in antidepressant clinical tests. [ 5 – 6 ] This article clarified and stated the above worries and misunderstandings. In addition, we analyzed possible factors that may influence the absolute effect of antidepressants, with emphasis on issues that should be noted during the selection of the control drug, especially placebo controls, in antidepressant clinical tests; which can be used as reference of pharmaceutical enterprises and clinical researchers.…”

Section: Introductionmentioning

confidence: 88%

“…In addition, the personal differences of subjects, the subjective expectations of these subjects to the researchers, the absence of objective biological indicators to therapeutic evaluation, and other factors are confounding factors that influence judgment on the effectiveness of the test drug in antidepressant clinical tests. [ 6 – 8 , 10 ]…”

Section: Selection and General Measurement Of Control Drugs In Antidementioning

confidence: 99%

“…[ 5 ] Depressive disorder is special, compared with other diseases to the body; and many factors influence the absolute effect of antidepressants. [ 3 , 6 – 8 ] Till date, the selection of control drugs in domestically applied antidepressant clinical tests has mainly involved positive drug control and/or placebo control, and these 2 controls have their own advantages and disadvantages. [ 3 , 9 ] In domestic antidepressant clinical tests, there are many worries and misunderstandings on the selection of control drugs, especially placebo controls.…”

Section: Introductionmentioning

confidence: 99%

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Selection and measurement of control antidepressants in clinical tests for Chinese

Líu

Yang²,

Geng³

et al. 2017

Medicine

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Objective:The study aims to help domestic application units and research institutions improve their research quality of antidepressant clinical tests by studying and analyzing the current status and problems in selecting control drugs during domestic antidepressant clinical tests and illustrating some key problems that should be noted when selecting the control drug in such researches.Methods:Considering the current domestic and overseas status of control drug selection in antidepressant clinical tests, various considerations, and misunderstandings on control drug selection in domestic antidepressant clinical tests were clarified and described, and possible factors that may influence the absolute effect of antidepressants were analyzed. Furthermore, problems that should be noted in selecting control drugs for the antidepressant clinical test, especially the placebo control, were stated.Results:During the antidepressant clinical research, selecting placebo controls conform to moral philosophy and safety requirements. To verify the absolute effect of a test drug, a placebo control should be set or 3-arm tests should be conducted as far as possible. Possible factors that may affect the absolute effect of the test drug, including illness severity of the subject at baseline and research scale, should be given consideration.Conclusions:Application units and research institutions should consider the selection of subjects, control the failure rate, strengthen safety risks, and control and intensify quality control to further improve the overall quality and research level of domestic antidepressant clinical tests.

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“…The Academic Editor also noted that per clinical practice guidelines, trials of antidepressants should generally last 8-12 weeks [4] and it generally requires 4-8 weeks of treatment to determine whether a patient is responsive to a particular intervention [5]. The authors noted that trials identified in published systematic reviews [6,7,8] used the same duration of fluoxetine treatment as was applied in [1]. The authors further commented that the fluoxetine dose used aligns with starting doses applied in clinical practice [4].…”

mentioning

confidence: 99%

Retraction: Individualized Homeopathic Treatment and Fluoxetine for Moderate to Severe Depression in Peri- and Postmenopausal Women (HOMDEP-MENOP Study): A Randomized, Double-Dummy, Double-Blind, Placebo-Controlled Trial

Editors¹

2020

PLoS ONE

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Following the publication and correction of this article [1, 2], questions were raised about the study design and reporting that prompted a full reassessment of the article. This post-publication evaluation involved three senior staff editors, a statistical reviewer, and a member of PLOS ONE's Editorial Board, and identified the following concerns: • The individualized homeopathic treatment (IHT) and the decision-making framework for treatment adjustments were not reported in sufficient detail to enable reproducibility of the study or an assessment as to the clinical validity of treatment choices. In response to this issue, the authors provided information in post-publication discussions about the individualized homeopathic consultations and guidance used for homeopathic prescription, and commented that potencies of homeopathic remedies were selected on the basis of homeopathic principles. Citing a 2014 systematic review of clinical trials involving IHT [3], the authors commented that the replicability of IHT has been demonstrated by previous studies that applied the same treatment approach to other medical conditions. They also asserted that the information reported in [1] was sufficient to enable replication by trained IHT practitioners, and that the study was reported per CONSORT criteria and the RedHot supplement to CONSORT for homeopathy clinical trials.

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Comparison between herbal medicine and fluoxetine for depression: A systematic review of randomized controlled trials

Cited by 30 publications

References 5 publications

Managing Depression withBupleurum chinenseHerbal Formula: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Managing Depression withBupleurum chinenseHerbal Formula: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Selection and measurement of control antidepressants in clinical tests for Chinese

Retraction: Individualized Homeopathic Treatment and Fluoxetine for Moderate to Severe Depression in Peri- and Postmenopausal Women (HOMDEP-MENOP Study): A Randomized, Double-Dummy, Double-Blind, Placebo-Controlled Trial

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