Comparison between lidocaine and NaCl 0.9% inhalation in heart rate and blood pressure changes during laryngoscopy and intubation

Soenarto, Ratna Farida; Pryambodho,; Adji, Muhammad Prakoso

doi:10.15562/bjoa.v3i1.137

Cited by 2 publications

(2 citation statements)

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“…Similar to our study Soenarto R et al also found out that MAP was higher in the NaCl group as compared to the 1.5 mg/kg nebulised lidocaine group at all-time intervals postintubation. 18 There are some limitations of our study as we have not measured the plasma concentration of lidocaine which might provide more about the safety of inhalation lidocaine. Parkes SB et al observed that inhalation of nebulised lidocaine at a dose of 6 mg/kg produces peak plasma lidocaine concentrations which are well below the toxic threshold of 5 mg/l.…”

Section: Discussionmentioning

confidence: 97%

“…Nasotracheal intubation also stimulates the nasal cavity and nasopharynx which doesn't occur during orotracheal intubation. 18 Moreover in nasotracheal intubation duration is prolonged than orotracheal intubation. 3 In our study, we used lidocaine 4% in nebulisation form, an amide local anaesthetic to blunt the haemodynamic response during nasotracheal intubation.…”

Section: Discussionmentioning

confidence: 99%

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A prospective study evaluating the effect of nebulised lidocaine on haemodynamic responses during nasotracheal intubation

Gaurav¹,

Verma²,

Verma³

et al. 2022

IJCA

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: Laryngoscopy and endotracheal intubation result in a significant increase in haemodynamic stress response which is well tolerated by healthy patients but in patients with significant coronary artery or cerebrovascular diseases, if it is not prevented adequately may lead to myocardial ischemia and cerebral haemorrhage.: This prospective comparative study was conducted between August 2019-July 2020 to study the effect of nebulised lidocaine on haemodynamic stress responses (primarily mean arterial blood pressure also heart rate, systolic blood pressure and diastolic blood pressure) during nasotracheal intubation. 94 patients who underwent head and neck surgery under general anaesthesia requiring nasotracheal intubation were randomised into two groups using a computational random number, Group A (control group): was nebulised with 5 ml of normal saline. Group B: was nebulised with 5ml of Lidocaine 4% solution. Heart rate(HR), systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial blood pressure(MAP), and SpO2 were observed before and after nebulisation, just before intubation, immediately after intubation and at 3, 5 10 min after intubation.: On comparing SBP, DBP, MAP and heart rate immediately after intubation with pre-intubation values, there was a significant surge in both groups but an increase in the control group was more in comparison to the lidocaine group(p<.05). Thereafter MAP, SBP, DBP and HR gradually decreased till the duration of study i.e. 10 minutes.: The administration of nebulised 4% Lidocaine inhalation before induction attenuates cardiovascular response (primarily in terms of MAP also SBP, DBP and HR) that occurs due to nasotracheal intubation.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

A prospective study evaluating the effect of nebulised lidocaine on haemodynamic responses during nasotracheal intubation

Gaurav¹,

Verma²,

Verma³

et al. 2022

IJCA

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Efficacy of Intravenous Lignocaine Versus Topical Lignocaine in Attenuation of Haemodynamic Surge During Laryngoscopy and Intubation in Patients Undergoing Surgery Under Generalanaesthesia - A Single Blind Randomized Control Study

Piplai

Roy

Dutta

et al. 2021

ijsr

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The present study was undertaken to evaluate the efcacy of intravenous lignocaine versus topical lignocaine for attenuating haemodynamic response during laryngoscopy and intubation in patients undergoing surgery under general anaesthesia. This single blind randomized control study was done on sixty patients of either sex aged between 18 to 55 years, of American Society of Anesthesiologists (ASA) status class I undergoing elective surgery under general anesthesia with endotracheal intubation. Patients were randomly allocated into two groups (group A and group B). Group A and Group B received intravenous preservative free lignocaine hydrochloride 2% 2 mg/kg and topical (nebulized) lignocaine hydrochloride 4% at 2mg/kg. Heart rate, systolic, diastolic and mean blood pressure was documented before administering premedication (T0), at time of intubation (TI) and 1 min (T-1), 2 min (T-2) & 5 min (T- 5) after intubation. Attenuation in the HR , SBP, DBP, MBPwere found statistically signicant (P<0.05) in group B in comparison to the group A. So, to conclude, topical lignocaine 4% blunts haemodynamic response to laryngoscopy and intubation better than intravenous lignocaine 2% when other confounding factors are eliminated.

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Comparison between lidocaine and NaCl 0.9% inhalation in heart rate and blood pressure changes during laryngoscopy and intubation

Cited by 2 publications

References 0 publications

A prospective study evaluating the effect of nebulised lidocaine on haemodynamic responses during nasotracheal intubation

A prospective study evaluating the effect of nebulised lidocaine on haemodynamic responses during nasotracheal intubation

Efficacy of Intravenous Lignocaine Versus Topical Lignocaine in Attenuation of Haemodynamic Surge During Laryngoscopy and Intubation in Patients Undergoing Surgery Under Generalanaesthesia - A Single Blind Randomized Control Study

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