Comparison between Outcomes of Vitrectomy in Granulomatous and Nongranulomatous Uveitis

Takayama, Kei; Tanaka, Atushi; Ishikawa, Sho; Mochizuki, Manabu; Takeuchi, Masaru

doi:10.1159/000441255

Cited by 4 publications

(7 citation statements)

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“…The diagnostic vitrectomy used in this study was useful to rule out various etiologies causing VO and consequently allows choices of appropriate therapeutic options. [ 13 , 15 , 18 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 9 – 11 ] These achievements promote the use of therapeutic vitrectomy in patients with VO caused by uveitis of unknown etiology. [ 12 – 15 ] Therefore, the diagnostic yield and therapeutic effects of vitrectomy in uveitic eyes with VO are improving, although surgical outcome in cases of infectious uveitis, especially endophthalmitis, remains unfavorable.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of diagnostic and therapeutic vitrectomy for vitreous opacity associated with uveitis with various etiologies

et al. 2018

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Vitreous opacity (VO) is a common feature of intermediate uveitis, posterior uveitis, and panuveitis. Fundus observation is critical for determining the etiology of uveitis, however, is often interfered with VO. In these clinical settings, vitrectomy contributes to a correct diagnosis and guides alternative management strategies. The purpose of this study was to evaluate the diagnostic yield and surgical outcome of vitrectomy in uveitic patients with VO and compare the visual outcome between infectious and noninfectious uveitis. Forty-five eyes with uveitis-associated VO underwent diagnostic and therapeutic vitrectomy, and etiological diagnosis of uveitis was confirmed in 34 of 45 eyes (75.6%). The diagnoses were infectious uveitis in 13 eyes (28.9%), noninfectious uveitis in 21 eyes (46.7%), and unidentified uveitis in 11 eyes (24.4%). Visual acuity (VA) improvement rates at 6 months after surgery were 69.2%, 76.2%, and 90.9% in the infectious, noninfectious, and unidentified uveitis groups, with no significant difference among 3 groups. Significant decrease in inflammation score after vitrectomy was observed only in the infectious uveitis group. This study demonstrated that diagnostic vitrectomy for inflammatory eyes with VO of unknown etiology was effective in infectious and noninfectious uveitis, and the therapeutic effect of VA improvement was observed in both types of uveitis.

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“…The diagnostic vitrectomy used in this study was useful to rule out various etiologies causing VO and consequently allows choices of appropriate therapeutic options. [ 13 , 15 , 18 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of diagnostic and therapeutic vitrectomy for vitreous opacity associated with uveitis with various etiologies

et al. 2018

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“…The functional improvement of eyes with uveitis after PPV has been also associated with the reportedly improved intraocular inflammation [9,[14][15][16][17][18][19][20]. The effect of PPV on the inflammation status of eyes with uveitis has been evaluated in several previous studies, and the clearance of active inflammatory mediators from the vitreous cavity has been advocated as the main factor responsible for the decreased uveitis activity.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Safety and Efficacy of Pars Plana Vitrectomy for Uveitis: Experience of a Tertiary Referral Centre in the United Kingdom

Faouri

Ally

Lippera

et al. 2023

JCM

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Aim: To evaluate the effectiveness of pars plana vitrectomy (PPV) without macular intervention on uveitis eyes with persistent vitreous inflammation/opacities in terms of visual acuity (VA), intraocular inflammation and macular profile. Methods: We carried out a single-center retrospective study of patients with uveitic eyes that underwent PPV without intervention on the macula due to persistent vitreous inflammation/opacities. The primary outcome measures were best-corrected visual acuity (BCVA), intraocular inflammation and macular profile at 3, 12 and 24 months after surgery. Results: Twenty-seven eyes of twenty-six patients were analyzed. Overall, 77.8% had an improvement of VA (55% by 0.3 LogMAR or more); 62.5% of patients had no intraocular inflammation, and the number of patients on systemic steroids and second-line immunosuppressives was reduced by 26% at 12 months; 87.5% of patients had resolution of macular oedema at 12 months. Conclusion: PPV for persistent vitreous inflammation/opacities is safe and effective, showing beneficial outcomes in terms of improvement of BCVA and the reduction in inflammation.

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“…Прогноз неосложненного увеита при адекватной терапии, как правило, благоприятный. Вместе с тем более чем у половины пациентов воспаление принимает хроническое рецидивирующее течение, что обуславливает высокий процент потери зрительных функций и инвалидизации пациентов [3,4]. Последнее обстоятельство вызывает необходимость поиска причин неблагоприятного исхода данной патологии.…”

Section: резюме _____________________________________________________...unclassified

Detection of Torque Teno Virus in Intraocular Fluid in Inflammatory Diseases of the Choroid

Марченко,

Егоров,

Семёнов

et al. 2023

Клиническая Инфектология И Паразитология

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Целью исследования являлось определение наличия ДНК Torque teno virus (TTV, ТТ-вирус) во внутриглазной жидкости (ВГЖ) у пациентов с различными формами воспаления сосудистой оболочки глаза. В данное исследование было включено 18 пациентов (8 мужчин и 10 женщин) в возрасте от 37 до 92 лет. Участники исследования проходили стационарное лечение с воспалительными заболеваниями сосудистой оболочки глаза, девяти из них было ранее проведено хирургическое лечение по поводу катаракты с имплантацией интраокулярной линзы. У включенных в исследование забирались образцы ВГЖ с помощью процедуры парацентеза передней камеры. В полученных образцах осуществлялось обнаружение ДНК TTV с использованием полимеразной цепной реакции в режиме реального времени. ДНК TTV была обнаружена в 12 (66,7%) из 18 образцов водянистой влаги. Частое обнаружение TTV в ВГЖ рождает гипотезу о том, что TTV может быть фактором риска, маркером или патогеном, вызывающим генерализованное воспаление сосудистой оболочки глаза. The purpose of the study was to determine the presence of Torque teno virus (TTV) DNA in the intraocular fluid in patients with various forms of inflammation of the choroid. This study included 18 patients (8 men and 10 women) aged 37 to 92 years. The participants of the study were hospitalized with inflammatory diseases of the choroid, nine of them had previously undergone cataract removal with intraocular lens implantation. Samples of intraocular fluid were taken by using an anterior chamber paracentesis procedure. After that, TTV DNA was detected by using real-time polymerase chain reaction. TTV DNA was detected in 12 (66.7%) of 18 aqueous humor samples. The frequent detection of TTV in the intraocular fluid gives rise to the hypothesis that TTV may be a risk factor, marker or pathogen causing generalized inflammation of the choroid.

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Comparison between Outcomes of Vitrectomy in Granulomatous and Nongranulomatous Uveitis

Cited by 4 publications

References 39 publications

Assessment of diagnostic and therapeutic vitrectomy for vitreous opacity associated with uveitis with various etiologies

Assessment of diagnostic and therapeutic vitrectomy for vitreous opacity associated with uveitis with various etiologies

Long-Term Safety and Efficacy of Pars Plana Vitrectomy for Uveitis: Experience of a Tertiary Referral Centre in the United Kingdom

Detection of Torque Teno Virus in Intraocular Fluid in Inflammatory Diseases of the Choroid

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