Comparison between Pharmacokinetic and Pharmacodynamic of Single- Doses of Furosemide 40 mg Tablets

Abstract

This study was to evaluate and compare the pharmacokinetic and pharmacodynamic behavior of two formulations of furosemide (CAS 54-31-9) 40 mg tablets, administered as a single dose to healthy subjects. Plasma concentrations of furosemide were determined with a validated method by liquid chromatography coupled to mass spectrometry (LC-MS/MS). We obtained the parameters: AUC 0-t , AUC 0-∞ , K el , T 1/2 , C max e T max. The following parameters were determined in urine: Sodium, Potassium and Chlorine and the total volume. The 90% confidence intervals for the ratio of C max (93.63-121.92%), AUC 0-t (96.80-115.72%) and AUC 0-∞ (98.45-117.43%) respectively for test and reference. Statistical analysis of the similarity of the parameters for urinary volume, excretion of sodium, potassium and chlorine and assuming that both formulations reach the same plasma levels, we expect that the pharmacological effect is also the same. Whereas the rate and extent of absorption, both products can be considered therapeutic equivalents.

Role of Novel Hole Technology in Fast Dissolving Tablets

“…Post compression parameters: All the prepared tablets were subjected to various physical characteristics like Crushing strength, Friability, Thickness, Diameter, Hole depth, Disintegration time, Wetting time, Weight variation, Drug content [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

“…In-vitro disintegration time: In the disintegration time study, the tablets are taken and introduced in each tube of disintegration apparatus, and the tablet rack of the disintegration apparatus has to be positioned into a 1 litre beaker containing 900 ml of distilled water and time of disintegration was recorded at 37 ± 2°C [23][24][25][26][27][28].…”

Formulation and Evaluation of Fast Dissolving Tablets of Diclofenac Sodium by Novel Hole Technology

“…Characteristics like tapped density, bulk density, carr's index, hausner,s ratio were studied for powder blend of formulations which are ready to compress in to tablets [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

“…In the disintegration time study, the tablets were taken and introduced in each tube of disintegration apparatus, and the tablet rack of the disintegration apparatus was positioned into a 1-litre beaker containing 900ml of distilled water and time of disintegration was recorded at 37 ± 2°C [23][24][25][26][27][28].…”

Preparation and In-vitro Evaluation of Metformin HCl Tablets Containing Sustained Release Beads for Increasing Therapeutic Window

“…The formed alginate beads were allowed to harden for 20 minutes. Then beads were filtered and washed with deionized water and dried in a hot air oven 60ºc for 2 hours [16][17][18][19][20].…”