Comparison between porphin, chlorin and bacteriochlorin derivatives for photodynamic therapy: Synthesis, photophysical properties, and biological activity

Zhu, Wei; Gao, Yan; Liao, Ping-Yong; Chen, Dan-Ye; Sun, Ning-Ning; Thi, Phuong Anh Nguyen; Yan, Yuan; Wu, Xiyong; Chen, Zhilong

doi:10.1016/j.ejmech.2018.10.005

Cited by 39 publications

(26 citation statements)

References 50 publications

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“…But, the difficult preparation, low yield and poor stability of bacteriochlorins limited their applications. 25,40 Inspired by the structure of bacteriochlorins, an analogue of bacteriochlorin, FBC , was synthesized via one-step diimide reduction of TFPP . TFPP could be directly obtained using the original reactive agents pentafluorobenzaldehyde and pyrrole, according to previous studies.…”

Section: Resultsmentioning

confidence: 99%

An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

2021

Chem. Sci.

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Section: Resultsmentioning

confidence: 99%

An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

2021

Chem. Sci.

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Section: Discussionmentioning

confidence: 99%

“…Porphyrins normally exhibit a peak of absorbance around 400 nm, the Soret Band, with subsequent absorbance peaks found at longer wavelengths up to 630 nm, with little absorption within the UV spectrum. However, the molecule bacteriochlorin, a close relation of porphyrin, does exhibit dual absorption peaks at 349 nm and 372 nm [32]. Moreover, retinal accumulation of porphyrin-related compounds has been widely exploited in the use of photodynamic therapy to treat neovascular AMD, where the photosensitisers primarily occupy the choroid and RPE [33], thus providing a rationale for the role of porphyrin-related macromolecules in native retinal photosensitivity.…”

Section: Discussionmentioning

confidence: 99%

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Quantitative Action Spectroscopy Reveals ARPE-19 Sensitivity to Long-Wave Ultraviolet Radiation at 350 nm and 380 nm

Anderson

McLeod

Bagnaninchi

et al. 2021

Preprint

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The role of ultraviolet radiation (UVR) exposure in the pathology of age-related macular degeneration (AMD) has been debated for decades with epidemiological evidence failing to find a clear consensus for or against it playing a role. A key reason for this is a lack of foundational research into the response of living retinal tissue to UVR in regard to AMD-specific parameters of tissue function. We, therefore, explored the response of cultured retinal pigmented epithelium (RPE), the loss of which heralds advanced AMD, to specific wavelengths of UVR across the UV-B and UV-A bands found in natural sunlight. Using a bespoke in vitro UVR exposure apparatus coupled with bandpass filters we exposed the immortalised RPE cell line, ARPE-19, to 10nm bands of UVR between 290 and 405nm. Physical cell dynamics were assessed during exposure in cells cultured upon specialist electrode culture plates which allow for continuous, non-invasive electrostatic interrogation of key cell parameters during exposure such as monolayer coverage and tight-junction integrity. UVR exposures were also utilised to quantify wavelength-specific effects using a rapid cell viability assay and a phenotypic profiling assay which was leveraged to simultaneously quantify intracellular reactive oxygen species (ROS), nuclear morphology, mitochondrial stress, epithelial integrity and cell viability as part of a phenotypic profiling approach to quantifying the effects of UVR. Electrical impedance assessment revealed unforeseen detrimental effects of UV-A, beginning at 350nm, alongside previously demonstrated UV-B impacts. Cell viability analysis also highlighted increased effects at 350nm as well as 380nm. Effects at 350nm were further substantiated by high content image analysis which highlighted increased mitochondrial dysfunction and oxidative stress. We conclude that ARPE-19 cells exhibit a previously uncharacterised sensitivity to UV-A radiation, specifically at 350nm and somewhat less at 380nm. If upheld in vivo, such sensitivity will have impacts upon geoepidemiological risk scoring of AMD.

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“…Unsur hidrogen dapat dihasilkan dari air melalui proses elektrolisis (74)(75)(76) . Klorin (77,78) merupakan salah satu unsur kimia dengan simbol Cl dengan nomor atom 17. Senyawa ini berada digolongan halogen (79)(80)(81)(82)(83) , senyawa yang paling ringan kedua berada diantara fluor dan bromin.…”

Section: Karakter Atom Penyusun Dari Senyawa Nh4cl 51 Nitrogen N Gamunclassified

Analisis Molekular dan Transpor Ion Amonium Clorida

Rhaska¹,

Zainul²

2019

Preprint

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Ammonium Chlorida merupakan seanyawa anorganik dengan rumus kimia NH4Cl, berupa garam Kristal putih yang sangat mudah larut dalam air.Ammonium Chlorida banyak digunakan pada bidang industry. Tujuan dari review ini untuk mengetahui karakteristik molekul dan transpor ion Ammonium Chlorida. Metode yang digunakan untuk mengetahui karakteristik molekul yaitu metode pemodelan komputasi di ChemOffice 15.0, dan untuk mengetahui transpor ion Ammonium Chlorida yaitu dengan parameter konduktivitas, viskositas, mobilitas ion, dan gerakan hanyut.Hasil yang didapat yaitu struktur molekul Ammonium Chlorida pada analisis molekuler 2D, dan bentuk molekul 3D. Ammonium klorida memiliki sifat termokimia dalam fasa solid dengan ΔS,C,ΔHf,ΔG pada tekanan 1 atm pada suhu 25°C yang masing-masing memiliki nilai 94,56 J mol-1 K-1, 84,1 J mol-1 K-1, -314,43 kJmol-1, dan -202,97 kJmol-1. Pada suhu yang 100°C dengan tekanan yang sama 1 atm ΔH reaksi yang didapatkan bernilai positif sehingga reaksi pembentukan NH4Cl bersifat endotermis. Interaksi molekul yang terjadi pada ion NH4Cl dapat diperhatikan melalui beberapa parameter, diantaranya adalah konduktivitas, mobilitas, serta kecepatan hanyut ionnya. Konduktivitas dari NH4Cl dipengaruhi oleh konsentrasi, semakin banyak ion yang ada dalam larutan maka mobilitas ion yang juga berhubungan dengan kecepatan hanyut dalam larutan akan semakin berkurang sehingga nilai konduktivitas akan menurun. Mobilitas ion NH4+ yaitu 3,5×10-8m2s-1V-1, serta kecepatan hanyut NH4Cl sebesar 3,00 V/cm. Berdasrkan metoda komputasi dengan ChemOffice 3D, energy yang dibutuhkan NH4Cl untuk bergerak sebesar 14,87 kcal/mol

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Comparison between porphin, chlorin and bacteriochlorin derivatives for photodynamic therapy: Synthesis, photophysical properties, and biological activity

Cited by 39 publications

References 50 publications

An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

Quantitative Action Spectroscopy Reveals ARPE-19 Sensitivity to Long-Wave Ultraviolet Radiation at 350 nm and 380 nm

Analisis Molekular dan Transpor Ion Amonium Clorida

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