Comparison between The Effect of Sucralose and Sodium Saccharin on Some Physiological Parameters in Male Albino Rats

Helal, Eman G.E.; Al-Shamrani, Abdullah; Abdelaziz, Mohamed A.; El-Gamal, Mariam S.

doi:10.21608/ejhm.2019.28025

Cited by 10 publications

(15 citation statements)

References 17 publications

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“…This disturbance is a direct result of the liver tissue deterioration caused by the essential elements (sucralose, chromium, and psyllium) and (chromium and psyllium) found in Aplex and Venera, respectively. These findings are in line with those of other researchers [ 9 , 30 ].…”

Section: Discussionsupporting

confidence: 94%

“…Our findings were consistent with previous studies [ 32 , 33 ] which suggested that chromium might cause liver deterioration. Moreover, Aplex contains sucralose which is known as a hepatoxic agent in previous studies [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Psyllium, as a fiber, can help to avoid obesity and its consequences [ 8 ]. Sucralose, one of the most recent artificial sweeteners, is also present in Aplex [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of the Antiobesity Drugs Aplex and Venera on Certain Biochemical and Physiological Indices in Obese Adult Male Albino Rats

Elpasty

Helal

Algendy

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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Background. Because of the growing incidence of obesity, the use of synthetic antiobesity medicines as weight-loss agents has grown in popularity, although their usefulness has yet to be established. Two of such medicines are Aplex and Venera. This study is designed to determine the potential dangers of Aplex and Venera on certain biochemical and physiological indicators in obese adult male rats. Methods. Twenty-one obese male albino rats (9 weeks old and having a body mass of 220 ± 20 g) were divided into three equal groups: the control group (vehicle treatment), the Aplex group (0.1 mg/kg/day) for 30 days, and the Venera group (0.1 mg/kg/day) for 30 days. Results. The values of serum glucose, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), total protein, total cholesterol (TC), high-density lipoprotein (HDL), very-low-density lipoprotein (VLDL), TC/HDL ratio, testosterone, thyroxine (T4), and leptin did not differ significantly between the treated and control groups. In contrast, the treated groups had substantial changes in bodyweight, serum alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), albumin, globulin, albumin/globulin ratio (A/G ratio), triglycerides (TG), low-density lipoproteins (LDL), LDL/HDL ratio, urea, creatinine, and triiodothyronine (T3) levels. Conclusion. The findings indicate that Aplex and Venera have negative impacts on crucial biochemical and physiological indicators, particularly liver and kidney functioning.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Effects of the Antiobesity Drugs Aplex and Venera on Certain Biochemical and Physiological Indices in Obese Adult Male Albino Rats

Elpasty

Helal

Algendy

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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“…The two tested sweeteners harmfully altered the biochemical markers in liver and kidney. Helal et al [28] reported an increase in AST and ALT activities, serum creatinine and urea levels in rat groups receiving sucralose and sodium saccharin. Sucralose is not transported through the gut epithelium, not metabolized by bacteria in the large intestine and is excreted in urine.…”

Section: Discussionmentioning

confidence: 98%

Hazard Effects of Chronic consumption of Sucralose and Saccharin-Sodium Cyclamate Mixture in Murine Model

et al. 2021

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Background: Sucralose and saccharin-cyclamate mixture are considered as safe commercial artificial sweeteners with many health authorities instead of natural sugar. We aimed to reveal their effects on the physiological, immunological and histological profiles. Methods and results mg/ml) in drinking water for 8 and 16 weeks. Only sucralose caused a temporary significant increase in blood glucose after 8 weeks that was eliminated after 16 weeks. WBCs count was decreased significantly after 16 weeks of sucralose administration. Aspartate aminotransferase creatinine (Cr) recorded an increase at 8 and 16 weeks due to the two artificial sweeteners intake. Both artificial sweetener induced a significant increase in interleukin (IL (LPS) levels with a progress from 8 th to 16 damage in kidney, liver, pancreas and urinary bladder. saccharin-cyclamate mixture, their chronic bladder. Moreover, they may interrupt the intestinal barriers leading to an cytokine secretions.

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“…Testosterone is synthesized from Leydig cells and is essential for spermatogenesis maintenance ( 56 ). Previous research observed high-dose NCS consumption significantly reduced the number of Leydig cells, which may negatively impact their ability to synthesize testosterone ( 56 ), while other research has also shown NCS consumption reduces testosterone levels ( 57 , 58 ). Future studies investigating diet and male reproductive outcomes should include serum testosterone and/or leydig cell analysis, in addition with sperm parameter assessment, as a potential mechanism in decreased male fertility.…”

Section: Discussionmentioning

confidence: 98%

The Impact of Non-caloric Sweeteners on Male Fertility: A Systematic Review and Narrative Synthesis in Rodent Models

2022

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Understanding the factors which influence fertility is essential for developing appropriate nutritional recommendations for couples trying to conceive. Non-caloric sweeteners (NCS) are increasing in the food chain and despite being no/low calorie, several adverse metabolic consequences have been attributed to their consumption. Their effects on reproduction have been relatively under-researched, particularly in males. This review aims to systematically review the literature for evidence of the effect of NCS on male fertility in rodents, with sperm parameters (sperm quantity and quality) assessed as primary outcomes. Given the lack of information available in humans this review has been carried out using evidence from rodent models. Risk of bias assessment was carried out using the Syrcle risk of bias tool. Nine studies met the inclusion criteria. Forty-four percent showed a negative effect of NCS on male reproductive parameters compared with controls. The effects of NCS on fertility have been conflicting and selected studies have been heterogeneous in relation to study design. It is unclear if NCS has an impact on male reproductive function. There is a need for randomized controlled trials using a standardized protocol for analysis, to formulate a clear message in terms of male fertility.

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Comparison between The Effect of Sucralose and Sodium Saccharin on Some Physiological Parameters in Male Albino Rats

Cited by 10 publications

References 17 publications

Effects of the Antiobesity Drugs Aplex and Venera on Certain Biochemical and Physiological Indices in Obese Adult Male Albino Rats

Effects of the Antiobesity Drugs Aplex and Venera on Certain Biochemical and Physiological Indices in Obese Adult Male Albino Rats

Hazard Effects of Chronic consumption of Sucralose and Saccharin-Sodium Cyclamate Mixture in Murine Model

The Impact of Non-caloric Sweeteners on Male Fertility: A Systematic Review and Narrative Synthesis in Rodent Models

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