Comparison between the indocyanine green fluorescence and blue dye methods for sentinel lymph node biopsy using novel fluorescence image-guided resection equipment in different types of hospitals

He, Kunshan; Chi, Chongwei; Kou, Deqiang; Huang, Wen‐He; Wu, Jundong; Wang, Yabing; He, Lifang; Ye, Jinzuo; Mao, Yamin; Zhang, Guo‐Jun; Wang, Jiandong; Tian, Jie

doi:10.1016/j.trsl.2016.07.010

Cited by 38 publications

(32 citation statements)

References 28 publications

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“…The detection rate of using ICG was reported to be 80 %, which is slightly lower than that of FS [20]. Furthermore, the use of ICG is associated with high cost equipment [21]. Recently, a new non-radioactive method was developed, using superparamagnetic iron oxide (SPIO) nanoparticles as tracer and manual magnetometer as detector.…”

Section: Discussionmentioning

confidence: 99%

10 % fluorescein sodium vs 1 % isosulfan blue in breast sentinel lymph node biopsy

et al. 2016

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BackgroundSentinel lymph node biopsy (SLNB) is well accepted to be a standard procedure in breast cancer surgery with clinically negative lymph nodes. Isosulfan blue is the first dye approved by the USA Food and Drug Administration for the localization of the lymphatic system. Few alternative tracers have been investigated. In this study, we aimed to compare the differences between 10 % fluorescein sodium and 1 % isosulfan blue in breast sentinel lymph node biopsy and to investigate the feasibility of using 10 % fluorescein sodium as a new dye for breast sentinel lymph node biopsy.MethodsA total of 30 New Zealand rabbits were randomly divided into the fluorescein sodium group and the isosulfan blue group (15 rabbits per group). Fluorescein sodium or isosulfan blue was injected subcutaneously into the second pair of mammary areolas.ResultsThe average fading time of the second lymph nodes in the isosulfan blue group was significantly shorter than that in the fluorescein sodium group. Moreover, the detection rates of SLNs were higher in the fluorescein sodium group than in the isosulfan blue group. No significant differences between the fluorescein sodium group and isosulfan blue group were observed regarding the distances between the detected sentinel lymph nodes and second pair of mammary areolas, the distances between the second lymph nodes and second pair of mammary areolas, the number of detected sentinel lymph nodes and second lymph nodes, the average dyeing time of the sentinel and the second lymph nodes, and the average fading time of the second lymph nodes.ConclusionsIn summary, we first reported that fluorescein sodium is a potential new tracer for breast sentinel lymph node biopsy.

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Section: Discussionmentioning

confidence: 99%

10 % fluorescein sodium vs 1 % isosulfan blue in breast sentinel lymph node biopsy

et al. 2016

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“…The current techniques used for SLNB include the use of methylene blue dye, radiocolloid and fluorescence guided surgery [19,7,8,20,21]. The current gold standard is the use of preoperative lymphoscintigraphy, intraoperative gamma probe detection with or without the use of blue dye [22].…”

Section: Intraoperative Imaging With Igc and Nir Fluorescencementioning

confidence: 99%

Sentinel lymph node mapping using ICG fluorescence or cone beam CT - a rabbit model feasibility study

Muhanna

Chan

Douglas

et al. 2020

Preprint

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Background Current sentinel lymph node biopsy (SLNB) techniques, including use of radioisotopes, have disadvantages including the use of a radioactive tracer. Indocyanine green (ICG) based near-infrared (NIR) fluorescence imaging and cone beam CT (CBCT) have advantages for intraoperative use. However, limited literature exists regarding their use in head and neck cancer SLNB.Methods This was a prospective, non-randomized study using a rabbit oral cavity VX2 squamous cell carcinoma model which develops lymph node metastasis. Pre-operatively, images were acquired by MicroCT and DCE-MRI. CBCT and NIR fluorescence imaging of ICG was used to map and guide the SLNB resection.Results Intraoperative use of ICG to guide fluorescence resection resulted in identification of all lymph nodes identified by pre-operative CT. CBCT was useful for near real time intraoperative imaging and 3D reconstruction.Conclusions This pre-clinical study further demonstrates the technical feasibility, limitations and advantages of intraoperative NIR-guided ICG imaging for SLN identification as a complementary method during head and neck surgery.

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“…The current techniques used for SLNB include the use of methylene blue dye, radiocolloid and uorescence guided surgery [8,9,[24][25][26]. The current gold standard is the use of preoperative lymphoscintigraphy, intraoperative gamma probe detection with or without the use of blue dye [27].…”

Section: Intraoperative Imaging With Cone Beam Ctmentioning

confidence: 99%

Sentinel lymph node mapping using ICG fluorescence and cone beam CT – a feasibility study in a rabbit model of oral cancer

Muhanna

Chan

Douglas

et al. 2020

Preprint

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Background: Current sentinel lymph node biopsy (SLNB) techniques, including use of radioisotopes, have disadvantages including the use of a radioactive tracer. Indocyanine green (ICG) based near-infrared (NIR) fluorescence imaging and cone beam CT (CBCT) have advantages for intraoperative use. However, limited literature exists regarding their use in head and neck cancer SLNB.Methods: This was a prospective, non-randomized study using a rabbit oral cavity VX2 squamous cell carcinoma model (n = 10) which develops lymph node metastasis. Pre-operatively, images were acquired by MicroCT. During surgery, CBCT and NIR fluorescence imaging of ICG was used to map and guide the SLNB resection.Results: Intraoperative use of ICG to guide fluorescence resection resulted in identification of all lymph nodes identified by pre-operative CT. CBCT was useful for near real time intraoperative imaging and 3D reconstruction. Conclusions: This pre-clinical study further demonstrates the technical feasibility, limitations and advantages of intraoperative NIR-guided ICG imaging for SLN identification as a complementary method during head and neck surgery.

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Comparison between the indocyanine green fluorescence and blue dye methods for sentinel lymph node biopsy using novel fluorescence image-guided resection equipment in different types of hospitals

Cited by 38 publications

References 28 publications

10 % fluorescein sodium vs 1 % isosulfan blue in breast sentinel lymph node biopsy

10 % fluorescein sodium vs 1 % isosulfan blue in breast sentinel lymph node biopsy

Sentinel lymph node mapping using ICG fluorescence or cone beam CT - a rabbit model feasibility study

Sentinel lymph node mapping using ICG fluorescence and cone beam CT – a feasibility study in a rabbit model of oral cancer

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