Comparison between ultrasonographic findings and fine needle aspiration cytology in differentiating malignant and benign thyroid nodules

Mohebbi, Mahdi; Dehaki, Mehrzad Gholampour; Mozaffari, Mahsa

doi:10.4081/ejtm.2019.8354

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…Arpana et al [14] USG features significantly associated with malignancy for thyroid lesions in his study; It has been reported that the size of the thyroid nodule is >30 mm, its borders are unclear, solid echotexture, hypoechoic lesion, microcalcification, and increased vascularity. Mohebbi et al [15] compared ultrasound features with fine needle aspiration cytology in the detection of thyroid nodules in clinical practice. Sonographic features such as microcalcification, hyper echogenicity, wider than elongated shape, no halo were found to be significantly associated with malignancy.…”

Section: Discussionmentioning

confidence: 99%

Comparison of thyroid fine needle aspiration biopsy and ultrasonography results

2023

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Thyroid nodules are one of the most common health problems in the community. Although most of the nodules are benign, Fine needle aspiration biopsy (FNAB) is requested due to malignancy concerns. In this research, the aim was to make a comparison of the results of thyroid ultrasonography (USG) and FNAB for thyroid nodules. This study was conducted retrospectively on the data of 532 patients. Detail Edu ultrasonographic assessment was conducted before the FNAB procedure and FNAB was performed by an endocrinology specialist. FNAB results and Thyroid USG features were compared, and thyroid FNAB results were graded using the classification of World Health Organization Bethesda-2017. The average age of the individuals included in the research was 49.99 ± 13.65 (min = 18-max = 97). According to the 2017 Bethesda classification, 74.6% of FNAB results were benign, 16% follicular lesion of undated mined significance or A type of undated mined significance, 0.9% were malignant, and 1.1% were suspicious for malignancy. When USG findings were compared according to FNAB results, it was found that malignant lesions were significantly higher in single nodules (non- cystic and non- mixed lesions). Lesions with a single nodule on USG were found to be 3.6 times more likely to be malignant (OR 95% CI: 1.172–11.352). The gold standard method for the diagnosis the presence of thyroid nodules is thyroid fine needle aspiration biopsy with ultrasound guidance. Taking samples from the correct nodule and component increases its value. The presence of a single nodule from the thyroid USG features was found to be an important predictor of malignancy according to the biopsy results.

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Section: Discussionmentioning

confidence: 99%

Comparison of thyroid fine needle aspiration biopsy and ultrasonography results

2023

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“…The taller-than-wide shape (vertical) was significantly associated with malignancy [23]. Taller-than-wide nodules with microcalcifications were most likely to be malignant, and there was a strong negative correlation between the size and taller-than-wide shape of a thyroid nodule [24].…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic Features of Intrathyroidal Thymic Carcinoma: Review and Analysis of 10 Cases

Wang¹,

Yang²,

Liu³

et al. 2022

Advanced Ultrasound in Diagnosis and Therapy

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Intrathyroidal thymic carcinoma (ITTC) is a rare epithelial tumor of the thyroid gland. Since ITTC is rare, its imaging findings have not been well defined. In the present study, we studied the US appearance of ITTC by analyzing ten cases retrospectively.Methods: Patients were identified by searching the surgical pathology records at our hospital. There were three male and seven female patients ranging in age from 40 to 79 years. The ultrasound (US) features were evaluated, and the relevant clinical data were combined with the fine needle aspiration (FNA) results from previous publications. Results:The average length of the nodules was 48 mm. Of all ten nodules, half were located in the right lobe of the thyroid, and half were located in the left lobe, either immediately adjacent to the lower lobe or within the lower part of the thyroid lobe. All nodules manifested with a completely solid composition and heterogeneous hypoechoic echogenicity. Three nodules had striped hyperechogenicity within the nodule. All nodules had irregular margins. Seven had a horizontal shape, and three had a vertical shape. Four nodules manifested with mainly peripheral vascularity, two nodules showed mainly central vascularity, and three had mixed vascularity. The vascularity of one remaining nodule was unknown. Cervical lymph node metastasis was detected in two cases by US examination. According to previous literature, FNA cytology revealed atypical type of thyroid cancer, poorly differentiated carcinoma, or a high-grade malignant thyroid neoplasm without further definitive classification. Conclusion:A large cancer-like nodule located within the lower thyroid in middle-aged people, combined with an atypical type of thyroid cancer after FNA, indicated that ITTC should be considered.

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“…FNA should be used for planning surgery for thyroid nodules and especially for follow-up with the patients [ 4 ]. Detection of thyroid malignancies at early stages is being achieved by this treatment, which is becoming more common because of its simplicity, cheap cost, and lack of serious consequences.…”

Section: Introductionmentioning

confidence: 99%

A Cytohistologic Correlation Study of Thyroid Lesions: Evaluation of Diagnostic Accuracy and Pitfalls of Fine Needle Aspiration Cytology

Gowardhan,

Valand

2024

Cureus

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Background Only about 5% of palpable thyroid nodules are malignant; the rest are entirely benign. In order to reduce the number of unnecessary treatments and properly identify situations that need surgical intervention, it is essential to distinguish between benign and malignant lesions prior to surgery. There exists a “grey zone” in thyroid cytology characterized by a significant decrease in diagnostic accuracy, making it difficult to precisely classify the lesion and leading to discrepancies. Aims and objectives The study aims to accomplish the following objectives: (1) assess the prevalence of thyroid lesions according to age and sex; (2) evaluate the accuracy of the fine needle aspiration cytology (FNAC) in diagnosing thyroid conditions; and (3) investigate the causes of cytohistological discordance within the context of this study. Materials and methods In our five-year study of thyroid lesions, 125 cases were studied for cytohistological correlation. Discrepant and likened FNAs were classified according to the diagnostic findings. A review of the cytological smears and histological sections was conducted. Results The cytological diagnoses were correlated with histopathology in 109 cases (90.83%). A total of 11 cases (09.16%) were discrepant. There were no false positives (FPs). The causes of false negative (FN) diagnoses in our study can be attributed to geographic misses and failure to recognize dual pathologies. Conclusion FNA is a very precise and time-saving technique for the diagnosis and subsequent management of palpable thyroid nodules. Patients having thyroidectomies have a much higher malignant yield, and the frequency of procedures performed on the thyroid is decreased. When FNA interpretation based on strict specimen sufficiency standards is considered along with clinical and imaging findings, the occurrence of FN and FP diagnoses is expected to decrease.

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Comparison between ultrasonographic findings and fine needle aspiration cytology in differentiating malignant and benign thyroid nodules

Cited by 5 publications

References 42 publications

Comparison of thyroid fine needle aspiration biopsy and ultrasonography results

Comparison of thyroid fine needle aspiration biopsy and ultrasonography results

Ultrasonographic Features of Intrathyroidal Thymic Carcinoma: Review and Analysis of 10 Cases

A Cytohistologic Correlation Study of Thyroid Lesions: Evaluation of Diagnostic Accuracy and Pitfalls of Fine Needle Aspiration Cytology

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