Comparison between visual assessment of dopaminergic degeneration pattern and semi-quantitative ratio calculations in patients with Parkinson’s disease and Atypical Parkinsonian syndromes using DaTSCAN® SPECT

Davidsson, Anette; Georgiopoulos, Charalampos; Dizdar, Nil; Granérus, Göran; Zachrisson, Helene

doi:10.1007/s12149-014-0878-x

Cited by 31 publications

(22 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, most APS patients showed a Grade 1 (burst striatum) uptake reduction, suggesting more severe dopamine depletion both in putamen and in caudate nucleus in APS. Both Kahraman et al and Davidsson et al have previously published similar results to these findings [7,8]. Compared to the B-SIT test, the visual assessment of DaTSCAN was more efficient in discriminating parkinsonism from Non-parkinsonism in terms of sensitivity (96%), specificity (80%) and diagnostic accuracy (92%).…”

Section: Datscansupporting

confidence: 59%

“…DaTSCAN imaging has high diagnostic performance in separating patients with PD from patients with non-parkinsonian syndromes [5,6]. However, the efficacy of DaTSCAN imaging in separating PD from APS has been a matter of controversy [4,[7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Ioflupane is a presynaptic radioligand with affinity to the presynaptic dopamine transporter protein, in the striatal dopaminergic terminals. Image acquisition, processing and automated semiquantitative evaluation were performed as previously described by our group [7]. We used EXINI DAT (EXINI Diagnostics AB, Lund, Sweden) for the quantification of our data.…”

mentioning

confidence: 99%

See 2 more Smart Citations

The diagnostic value of dopamine transporter imaging and olfactory testing in patients with parkinsonian syndromes

et al. 2015

Self Cite

View full text Add to dashboard Cite

The aim of the study was to compare the efficacy of olfactory testing and presynaptic dopamine imaging in diagnosing Parkinsons disease (PD) and atypical parkinsonian syndromes (APS); to evaluate if the combination of these two diagnostic tools can improve their diagnostic value. A prospective investigation of 24 PD patients, 16 APS patients and 15 patients with non-parkinsonian syndromes was performed during an 18-month period. Single photon emission computed tomography with the presynaptic radioligand I-123-FP-CIT (DaTSCAN (R)) and olfactory testing with the Brief 12-item Smell Identification Test (B-SIT) were performed in all patients. DaTSCAN was analysed semi-quantitatively, by calculating two different striatal uptake ratios, and visually according to a predefined ranking scale. B-SIT score was significantly lower for PD patients, but not significantly different between APS and non-parkinsonism. The visual assessment of DaTSCAN had higher sensitivity, specificity and diagnostic accuracy compared to olfactory testing. Most PD patients (75 %) had visually predominant dopamine depletion in putamen, while most APS patients (56 %) had visually severe dopamine depletion both in putamen and in caudate nucleus. The combination of DaTSCAN and B-SIT led to a higher rate of correctly classified patients. Olfactory testing can distinguish PD from non-parkinsonism, but not PD from APS or APS from non-parkinsonism. DaTSCAN is more efficient than olfactory testing and can be valuable in differentiating PD from APS. However, combining olfactory testing and DaTSCAN imaging has a higher predictive value than these two methods separately.

Funding Agencies|Ostergotland County Council (ALF); Swedish Parkinsons Foundation

show abstract

Section: Datscansupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The diagnostic value of dopamine transporter imaging and olfactory testing in patients with parkinsonian syndromes

et al. 2015

Self Cite

View full text Add to dashboard Cite

Funding Agencies|Ostergotland County Council (ALF); Swedish Parkinsons Foundation

show abstract

“…However, whereas this method has proved quite reliable [4,5], its ordinal and relatively crude nature has left some room for intermediate or difficult-to-classify cases, in particular those with questionable uptake deficit early in the disease course. More recently, semi-quantitative methods of assessment have been developed based on the ratio of manually drawn or automatically delineated striatal regions or volumes of interest (ROIs, VOIs) to background activity [6,7] using various protocols and software. While less prone to subjectivity bias or to intra-and inter-observer variability, these analyses require robust reference values, usually established on healthy subjects, to which data from individual patients can be compared.…”

Section: Introductionmentioning

confidence: 99%

Scan without evidence of dopaminergic deficit: A 10-year retrospective study

Nicastro

Garibotto

Badoud

et al. 2016

Parkinsonism & Related Disorders

View full text Add to dashboard Cite

Introduction: 123 I-ioflupane SPECT is a powerful method to assess nigrostriatal dopamine system integrity. Several independent studies have shown that 1e15% of patients with suspected degenerative parkinsonism, mainly PD, have scans without evidence of dopaminergic deficit (SWEDD). It has been proposed that most SWEDD patients either present with a non-degenerative condition mimicking PD, such as atypical tremor or dystonia, or demonstrate an abnormal scan when repeated later. We here hypothesized that scan interpretation methods may also play a crucial yet underestimated role in this issue. Methods: We previously established age-dependent reference values of striatal uptake by analyzing scans from a cohort of patients with non-degenerative conditions. We then studied a large population with well-established degenerative parkinsonism (N ¼ 410, 80% with PD), using identical imaging protocol, to evaluate the prevalence of patients with normal scans based on routine visual assessment. Each scan was eventually reassessed using the same automated method as for controls and a detailed 3D analysis. Results: Ten potential SWEDD cases (2.4%) were identified. However, both reassessment methods independently showed that these scans were all outside reference limits and/or visually abnormal when reexamined carefully, except for one case (0.2%) with corticobasal syndrome. Conclusion: SPECT misinterpretation emerges as an important contributor to the SWEDD population, suggesting that suspected SWEDD cases should prompt not only a serious diagnosis challenge but, equally important, a detailed scan reassessment. True SWEDD cases seem extremely rare in degenerative parkinsonism. We propose that the very concept of SWEDD is more confusing than helpful and should be definitely abandoned.

show abstract

“…These results demonstrate that both the update number and the FWHM of the Gaussian filter are considerably important factors in the assessment of the image quality. High contrast is needed for an accurate diagnosis because the shape and intensity of the striatum are important factors for differentiating between the NB and DB groups in visual interpretation [12]. Therefore, the update number and the FWHM of the Gaussian filter must be determined by considering the trade-off of the image contrast and the uniformity.…”

Section: Discussionmentioning

confidence: 99%

Optimization of iterative reconstruction parameters with 3-dimensional resolution recovery, scatter and attenuation correction in 123I-FP-CIT SPECT

et al. 2015

View full text Add to dashboard Cite

show abstract

Comparison between visual assessment of dopaminergic degeneration pattern and semi-quantitative ratio calculations in patients with Parkinson’s disease and Atypical Parkinsonian syndromes using DaTSCAN® SPECT

Cited by 31 publications

References 31 publications

The diagnostic value of dopamine transporter imaging and olfactory testing in patients with parkinsonian syndromes

The diagnostic value of dopamine transporter imaging and olfactory testing in patients with parkinsonian syndromes

Scan without evidence of dopaminergic deficit: A 10-year retrospective study

Optimization of iterative reconstruction parameters with 3-dimensional resolution recovery, scatter and attenuation correction in 123I-FP-CIT SPECT

Contact Info

Product

Resources

About