Comparison end-to-end anastomosis with ostomy after secondary surgical cytoreduction for recurrent high-grade serous ovarian cancer: observational single-center study

Matak, Luka; Mikuš, Mislav; Ćorić, Mario; Spagnol, Giulia; Matak, Magdalena; Vujić, Goran

doi:10.1007/s00404-023-06918-9

Cited by 6 publications

(13 citation statements)

References 27 publications

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“…Algumas mulheres relatam uma melhoria na vida sexual após a cirurgia devido ao alívio dos sintomas que estavam afetando sua saúde sexual, como dor durante o sexo ou sangramento uterino anormal. No entanto, outras mulheres podem experimentar mudanças negativas na libido, função sexual ou sensações durante o sexo 4,5 .…”

Section: Metodologiaunclassified

“…Outras desvantagens incluem o tempo de recuperação pós-operatória, potenciais mudanças na estrutura do corpo e possíveis impactos emocionais. É fundamental discutir cuidadosamente com o médico sobre os riscos e benefícios individuais, considerando também alternativas de tratamento antes de optar pela histerectomia 1,5 .…”

Section: Metodologiaunclassified

“…A escolha das técnicas anestésicas e cirúrgicas para uma histerectomia depende das necessidades e condições específicas de cada paciente, bem como da preferência do cirurgião e do centro médico. Algumas das técnicas cirúrgicas comuns incluem a histerectomia abdominal, vaginal, laparoscópica e robótica 5,7,8 .…”

Section: Técnicas Cirúrgicasunclassified

“…Dependendo das necessidades do paciente e das condições específicas, a histerectomia vaginal pode ser complementada com a remoção dos ovários e das trompas de Falópio, conhecida como salpingo-ooforectomia 5,10 .…”

Section: Técnicas Cirúrgicasunclassified

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Técnicas Cirúrgicas e Anestésicas na Histerectomia

Sena Filho,

Acioli,

Jales

et al. 2024

Braz. J. Implantol. Health Sci.

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Introdução: A histerectomia, remoção cirúrgica do útero, é um procedimento comum realizado em mulheres para tratar uma variedade de condições ginecológicas, como miomas uterinos, endometriose, sangramento uterino anormal e câncer ginecológico. Assim, ao longo dos anos, várias técnicas cirúrgicas foram desenvolvidas para realizar a histerectomia, incluindo a abordagem abdominal tradicional, a histerectomia vaginal, a histerectomia laparoscópica e a histerectomia robótica. Além disso, a escolha da anestesia também é um aspecto crucial no planejamento da histerectomia, com opções que incluem anestesia geral, anestesia regional (como a raquianestesia ou a epidural) e técnicas de anestesia local. Objetivo: Comparar os resultados clínicos, a segurança e a eficácia das diferentes técnicas cirúrgicas e abordagens anestésicas utilizadas na histerectomia. Metodologia: Foram utilizadas as bases de dados Cochrane, Scielo e Medline, buscando artigos publicados entre os anos de 2021 e 2024, nos idiomas Português ou Inglês. Considerações Finais: Em síntese, a seleção cuidadosa das técnicas cirúrgicas e anestésicas na histerectomia é fundamental para otimizar os resultados clínicos e a satisfação da paciente. Dessa forma, a histerectomia laparoscópica e a abordagem robótica surgem como alternativas viáveis e seguras à histerectomia abdominal, proporcionando menor morbidade pós-operatória e recuperação mais rápida. Quanto à anestesia, a abordagem deve ser personalizada, levando em consideração o perfil de segurança e eficácia de cada paciente.

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Section: Metodologiaunclassified

Section: Técnicas Cirúrgicasunclassified

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Técnicas Cirúrgicas e Anestésicas na Histerectomia

Sena Filho,

Acioli,

Jales

et al. 2024

Braz. J. Implantol. Health Sci.

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“…The 5-year survival rate is 75% to 80% for patients with local tumors and only 25% for those with distant metastases. Despite the favorable prognosis of early OC, the overall 5-year survival rate is only 48.6%, so there is an urgent need to develop effective prevention strategies to reduce the public health burden of OC [16,17]. In recent years, factors influencing OC risk have included hereditary risk factors (including absence of pregnancy, early age of menarche, and late age at menopause), smoking, benign gynecological conditions (including endometriosis, polycystic ovary syndrome, and pelvic inflammatory disease), and possibly talcum powder use [18,19].…”

Section: Introductionmentioning

confidence: 99%

Ovarian Cancer and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study

Guo

Xiao

et al. 2023

JCM

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(1) Background: Ovarian cancer (OC) and Parkinson’s disease (PD) represent a huge public health burden. The relationship of these two diseases is suggested in the literature while not fully understood. To better understand this relationship, we conducted a bidirectional Mendelian ran-domization analysis using genetic markers as a proxy. (2) Methods: Utilizing single nucleotide polymorphisms associated with PD risk, we assessed the association between genetically predicted PD and OC risk, overall and by histotypes, using summary statistics from previously conducted genome-wide association studies of OC within the Ovarian Cancer Association Consortium. Similarly, we assessed the association between genetically predicted OC and PD risk. The inverse variance weighted method was used as the main method to estimate odds ratios (OR) and 95% confidence intervals (CI) for the associations of interest. (3) Results: There was no significant association between genetically predicted PD and OC risk: OR = 0.95 (95% CI: 0.88–1.03), or between genetically predicted OC and PD risk: OR = 0.80 (95% CI: 0.61–1.06). On the other hand, when examined by histotypes, a suggestive inverse association was observed between genetically predicted high grade serous OC and PD risk: OR = 0.91 (95% CI: 0.84–0.99). (4) Conclusions: Overall, our study did not observe a strong genetic association between PD and OC, but the observed potential association between high grade serous OC and reduced PD risk warrants further investigation.

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Causal effect between breast cancer and ovarian cancer: a two-sample mendelian randomization study

Qian,

Xing,

Cheng

2024

BMC Cancer

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Objectives Improved breast cancer (BC) outcomes highlight the importance of secondary primary cancers (SPCs) on survivor prognosis. The objective of this study was to investigate the potential genetic association between primary BC and ovarian cancer (OC), laying the groundwork for the development of preventive strategies for SPC-OC following BC surgery. Methods This study aimed to assess the connection between BC and OC using a two sample Mendelian randomization (MR) approach, exclusively employing aggregate level data from publicly available genome wide association studies (GWASs). Finally, the Genetic Risk Scores (GRS) method was used for secondary analysis to verify the results robustness further. Results The IVW method revealed a genetic correlation between Overall BC and ER + BC with Serous borderline tumors, while ER-BC exhibited genetic correlation with Mucinous borderline tumors and high-grade serous ovarian cancer. The findings from the GRS method aligned with those of the primary analysis, reinforcing the study's robustness. Conclusion Our MR Study identifies an association between BC and OC, highlighting the importance of increased vigilance in clinical practice for individuals with a history of BC. Timely intervention and treatment measures should be taken when necessary. Supplementary Information The online version contains supplementary material available at 10.1186/s12885-024-13033-8.

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Comparison end-to-end anastomosis with ostomy after secondary surgical cytoreduction for recurrent high-grade serous ovarian cancer: observational single-center study

Cited by 6 publications

References 27 publications

Técnicas Cirúrgicas e Anestésicas na Histerectomia

Técnicas Cirúrgicas e Anestésicas na Histerectomia

Ovarian Cancer and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study

Causal effect between breast cancer and ovarian cancer: a two-sample mendelian randomization study

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