Comparison of 11C-Methionine PET and 18F-FDG PET in Patients with Primary Central Nervous System Lymphoma

Kawase, Yoshiroh; Yamamoto, Yuka; Kameyama, Reiko; Kawai, Nobuyuki; Kudomi, Nobuyuki; Nishiyama, Yoshihiro

doi:10.1007/s11307-010-0447-1

Cited by 50 publications

(25 citation statements)

References 20 publications

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“…It is well known that FDG-uptake on diffuse large B-cell lymphoma is higher than that on other types of lymphoma, and this characteristic feature could be helpful in differentiating between B-cell lymphoma and other histological tumors [26]. Similarly, PET can identify degenerative diseases, multiple sclerosis, infectious diseases and cerebral infarction [27]. In recent years, the use of 18 F-FDG PET and PET/CT has increased in routine practice at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of using 18F-FDG PET and PET/CT in immunocompetent patients with primary central nervous system lymphoma: A systematic review and meta-analysis

et al. 2017

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Background18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and PET/CT have become two of the most powerful tools for malignant lymphoma exploration, but their diagnostic role in primary central nervous system lymphoma (PCNSL) is still disputed. The purpose of our study is to identify the usefulness of 18F-FDG PET and PET/CT for detecting PCNSL.ResultsA total of 129 patients, obtained from eight eligible studies, were included for this systematic review and meta-analysis. The performance of 18F-FDG PET and PET/CT for diagnosing PCNSL were as follows: the pooled sensitivity was 0.88 (95% CI: 0.80–0.94), specificity was 0.86 (95% CI: 0.73–0.94), positive likelihood ratio (PLR) was 3.99 (95% CI: 2.31–6.90), negative likelihood ratio (NLR) was 0.11 (95% CI: 0.04-0.32), and diagnostic odds ratio (DOR) was 33.40 (95% CI: 10.40–107.3). In addition, the area under the curve (AUC) and Q index were 0.9192 and 0.8525, respectively.Materials and MethodsPubMed/MEDLINE, Embase and Cochrane Library were systematically searched for potential publications (last updated on July 16th, 2016). Reference lists of included articles were also checked. Original articles that reported data on patients who were suspected of having PCNSL were considered suitable for inclusion. The sensitivities and specificities of 18F-FDG PET and PET/CT in each study were evaluated. The Stata software and Meta-Disc software were employed in the process of data analysis.Conclusions18F-FDG PET and PET/CT showed considerable accuracy in identifying PCNSL in immunocompetent patients and could be a valuable radiological diagnostic tool for PCNSL.

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Section: Discussionmentioning

confidence: 99%

Diagnostic value of using 18F-FDG PET and PET/CT in immunocompetent patients with primary central nervous system lymphoma: A systematic review and meta-analysis

et al. 2017

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“…Amino acid metabolic imaging with MET-PET possesses high specificity in tumor detection, tumor delineation and differentiation of benign from malignant lesions in the brain [11]. MET-PET examination in PCNSL is limited and only a few reports demonstrate its diagnostic usefulness and evaluate the therapeutic effect [4, 12]. In our previous reports, PCNSL with typical MR findings showed, without exception, increased FDG and MET uptakes in the tumor before treatment [6].…”

Section: Discussionmentioning

confidence: 99%

Insufficiency of Positron Emission Tomography and Magnetic Resonance Spectroscopy in the Diagnosis of Intravascular Lymphoma of the Central Nervous System

Kawai¹,

Okada²,

Haba

et al. 2012

Case Rep Oncol

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Intravascular large B-cell lymphoma (IVL) is a rare type of extranodal lymphoma with an aggressive clinical course characterized by the proliferation of lymphoma cells within the lumen of small vessels. Diagnosis is often difficult because of marked variability in clinical presentation and nonspecific laboratory and radiological findings, especially when central nervous system (CNS) symptoms are the only manifestation. Modern metabolic imaging techniques such as positron emission tomography (PET) and ¹H-magnetic resonance spectroscopy (MRS) have been reported to be useful in the diagnosis of conventional primary CNS lymphoma. We report the case of a 69-year-old man who presented with a progressive leukoencephalopathic syndrome. The patient was examined by ¹⁸F-fluorodeoxyglucose and ¹¹C-methionine PET and MRS, but none of these examinations were able to show the presence of a tumor in the lesions or to clarify the tumor characteristics. Brain biopsy was the only way to obtain a definite diagnosis of IVL. The patient was treated intensively with standard immunochemotherapy but died 6 months after the diagnosis. Here, we discuss the insufficiency of modern metabolic imaging techniques, including PET and MRS, and recommend a rapid decision of brain biopsy in the diagnosis of IVL only involving the CNS.

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“…Nuutinen et al [111] studied 32 lymphoma patients and found MET-PET highly sensitive for the detection of disease sites although there was no correlation between MET uptake and patient outcome. Also, MET-PET has an advantage over FDG-PET in imaging of CNS lymphoma [112]. While these results are encouraging, it should be noted that no studies have shown the usefulness or cost-effectiveness of amino acid or nucleoside tracers in large patient cohorts.…”

Section: Newer Pet Tracersmentioning

confidence: 99%

Imaging of Non-Hodgkin Lymphomas: Diagnosis and Response-Adapted Strategies

El‐Galaly

Hutchings

2015

Cancer Treatment and Research

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Optimal lymphoma management requires accurate pretreatment staging and reliable assessment of response, both during and after therapy. Positron emission tomography with computerized tomography (PET/CT) combines functional and anatomical imaging and provides the most sensitive and accurate methods for lymphoma imaging. New guidelines for lymphoma imaging and recently revised criteria for lymphoma staging and response assessment recommend PET/CT staging, treatment monitoring, and response evaluation in all FDG-avid lymphomas, while CT remains the method of choice for non-FDG-avid histologies. Since interim PET imaging has high prognostic value in lymphoma, a number of trials investigate PET-based, response-adapted therapy for non-Hodgkin lymphomas (NHL). PET response is the main determinant of response according to the new response criteria, but PET/CT has little or no role in routine surveillance imaging, the value which is itself questionable. This review presents from a clinical point of view the evidence for the use of imaging and primarily PET/CT in NHL before, during, and after therapy. The reader is given an overview of the current PET-based interventional NHL trials and an insight into possible future developments in the field, including new PET tracers.

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Comparison of 11C-Methionine PET and 18F-FDG PET in Patients with Primary Central Nervous System Lymphoma

Abstract: There was no significant difference between T/N ratios using MET PET and FDG PET, although uptake of MET in CNS lymphoma was significantly lower than that of FDG. MET PET showed as high a sensitivity as FDG PET for the detection of primary lesions in patients with CNS lymphoma.

Cited by 50 publications

References 20 publications

Diagnostic value of using 18F-FDG PET and PET/CT in immunocompetent patients with primary central nervous system lymphoma: A systematic review and meta-analysis

Diagnostic value of using 18F-FDG PET and PET/CT in immunocompetent patients with primary central nervous system lymphoma: A systematic review and meta-analysis

Insufficiency of Positron Emission Tomography and Magnetic Resonance Spectroscopy in the Diagnosis of Intravascular Lymphoma of the Central Nervous System

Imaging of Non-Hodgkin Lymphomas: Diagnosis and Response-Adapted Strategies

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