Comparison of 2-octyl cyanoacrylate adhesive, fibrin glue, and suturing for wound closure in the porcine urinary tract

Marcovich, Robert; Williams, Antoinette L.; Rubin, Mark A.; Wolf, J. Stuart

doi:10.1016/s0090-4295(00)01075-x

Cited by 50 publications

(30 citation statements)

References 18 publications

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“…These authors used n-butyl-cyanoacrylate in the lacrimal canaliculi of rabbits and observed local diffuse infl ammatory response on days 7 and 14 after occlusion. Similar results have been reported by MARCOVICH et al (2001) on the histological analysis of the urinary tract of pigs after 7 days of n-butyl-acrylate being used.…”

Section: Discussionsupporting

confidence: 89%

“…Thus, it could be suggested that besides the presence of the adhesive in the canaliculi, the release of these toxic substances may have contributed to the irritability potential to sensitive individuals resulting in greater tearing. Furthermore, the degradation that takes place after polymerization releases substances such as cyanoacetate and formaldehyde, which can also cause infl ammation (MARCOVICH et al, 2001;GAGNAIRE et al, 2003;EL-DARS et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…At the time of this study, 2-octylcyanoacrylate cost 10 times more than n-butylcyanoacrylate and both, in comparison to ethylcyanoacrylate used by ROSA et al (2012), are expensive. However, both adhesives have longer carbon chains than ethyl-cyanoacrylate ensuring greater fl exibility, resistance, adherence and degradation time and are (MARCOVICH et al, 2001), thus, more advantageous than ethylcyanoacrylate. On the other hand, when compared to silicone plugs, their cost and the time remained in situ could be considered as advantages.…”

Section: Discussionmentioning

confidence: 99%

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Temporary occlusion of the inferior lacrimal punctum and canaliculi of dogs with n-butyl-cyanoacrylate and 2-octyl-cyanoacrylate

et al. 2014

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The occlusion of the inferior lacrimal punctum limits tear drainage and thus keeps it over the ocular surface, prolongs lubrication and minimizes the need of ocular lubricants. The aim of this study was to evaluate the effectiveness of n-butyl-cyanoacrylate and 2-octyl-cyanoacrylate adhesives in the occlusion of the inferior lacrimal punctum and canaliculi of dogs and their clinicalrepercussions over 180 days. Eleven dogs, were divided into two groups: occlusion with n-butyl-cyanoacrylate (GB, n=6) and with 2-octyl-cyanoacrylate (GO, n=5). Tear production, blepharospasm, ocular discharge, epiphora and conjunctival hyperemia were analyzed before the procedure and on days (T) 3,7,15, 30, 45, 60, 90, 120, 150 and 180 RESUMO A oclusão do ponto lacrimal inferior limita a drenagem da lágrima, mantendo-a sobre a superfície ocular, prolonga a lubrifi cação e minimiza a posologia de lubrifi cantes. Objetivou-se, com este estudo, avaliar a efetividade dos adesivos n-butil-cianoacrilato e 2-octil-cianocacrilato, na oclusão do ponto e canalículo lacrimais inferiores de cães e suas repercussões clínicas durante 180 dias. Para tanto, utilizaramse 11 cães distribuídos em dois grupos: oclusão com n-butilcianoacrilato (GB, n=6) e com 2-octil-cianoacrilato (GO; n=5).A produção lacrimal foi avaliada previamente ao procedimento e, posteriormente, aos 3, 7, 15, 30, 45, 60, 90, 120, 150

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Temporary occlusion of the inferior lacrimal punctum and canaliculi of dogs with n-butyl-cyanoacrylate and 2-octyl-cyanoacrylate

et al. 2014

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“…These requirements are fulfilled both in the application of polymers like poly(alkylcyanoacrylates), known as skin adhesives or surgical glues for the closure of wounds. 6 The most commonly used alkylcyanoacrylate is n-butylcyanoacrylate (BCA). In addition to being approved in medical applications, poly(n-butylcyanoacrylate) (PBCA) nanoparticles have been demonstrated to cross the blood-brain barrier efficiently.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics on a microscale: visualizing Cy5-labeled oligonucleotide release from poly(n-butylcyanoacrylate) nanocapsules in cells

Tomcin¹,

Baier²,

Landfester³

et al. 2014

IJN

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For successful design of a nanoparticulate drug delivery system, the fate of the carrier and cargo need to be followed. In this work, we fluorescently labeled poly( n -butylcyanoacrylate) (PBCA) nanocapsules as a shell and separately an oligonucleotide (20 mer) as a payload. The nanocapsules were formed by interfacial anionic polymerization on aqueous droplets generated by an inverse miniemulsion process. After uptake, the PBCA capsules were shown to be round-shaped, endosomal structures and the payload was successfully released. Cy5-labeled oligonucleotides accumulated at the mitochondrial membrane due to a combination of the high mitochondrial membrane potential and the specific molecular structure of Cy5. The specificity of this accumulation at the mitochondria was shown as the uncoupler dinitrophenol rapidly diminished the accumulation of the Cy5-labeled oligonucleotide. Importantly, a fluorescence resonance energy transfer investigation showed that the dye-labeled cargo (Cy3/Cy5-labeled oligonucleotides) reached its target site without degradation during escape from an endosomal compartment to the cytoplasm. The time course of accumulation of fluorescent signals at the mitochondria was determined by evaluating the colocalization of Cy5-labeled oligonucleotides and mitochondrial markers for up to 48 hours. As oligonucleotides are an ideal model system for small interfering RNA PBCA nanocapsules demonstrate to be a versatile delivery platform for small interfering RNA to treat a variety of diseases.

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“…Cyanoacrylates, such as 2-octyl-cyanoacrylate, contain a long carbon chain that hampers their degradation and therefore increases the accumulation of by-products, which have significant tissue toxicity and induce a high degree of inflammation (Woodward et al, 1965;Quinn et al, 1997;Vote and Elder, 2000;Marcovich et al, 2001). This process was corroborated by the histological changes observed in the GO group at day seven, such as the mild and moderate acute inflammatory and foreign body responses, followed by the resolution of the inflammatory response and the absence of a foreign body response at day 14.…”

Section: Score Variablesmentioning

confidence: 99%

Clinical and histological effects of the temporary occlusion of the rabbit nasolacrimal duct and point using cyanoacrylate adhesives

Cardoso

Ferreira

Miguel

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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The objective of this study was to evaluate the clinical and histological effects of occluding the nasolacrimal ducts and points of rabbits. For this study, 20 adult New Zealand rabbits, both males and females, weighing 3.2±0.4kg were allocated into two groups for n-butyl-cyanoacrylate occlusion (GB, n=10) or 2-octyl-cyanoacrylate occlusion (GO, n=10). The contralateral eyes served as the controls. The persistence of tears was evaluated daily using the Schirmer I test. Discomfort, eye discharge, epiphora, and conjunctival hyperemia were assessed prior to the procedure (T0) and during the 14 subsequent days (T1-T14). On days seven and 14, five animals from each group were euthanized, and their nasolacrimal ducts were collected, processed and analyzed by histology. In the GB group, the Schirmer test values differed from that at T0 at all of the subsequent time points, whereas there was no difference in the values observed from the GO group. Compared with the corresponding controls, the GO and GB groups differed significantly at almost all of the time points. When comparing the treatment groups, differences were found at T6, T7, T9, T10, T11, T12 and T14, with higher Schirmer values in the GB group. Epiphora was observed in the GB group from T1 to T8 and in the GO group from T1 to T6. Within seven days postocclusion, histology revealed a moderate foreign body reaction, with marked necrosis and sloughing of the canalicular epithelium, in the GO group, which was absent at day 14. In the GB group, a marked inflammatory reaction and a mild foreign body reaction were found at day seven, and the foreign body reaction was prevalent at day 14. This study demonstrated that both adhesives were effective in obstructing the nasolacrimal ducts and points of rabbits and that their application and handling are easy and free of complications. However, both adhesives promoted inflammatory and foreign body reactions that evolved to repair and regeneration at day 14 of evaluation.Keywords: dry eye, keratoconjunctivitis sicca, Schirmer test, tear RESUMO Avaliaram-se os efeitos clínicos e histológicos da oclusão do ponto e do duto nasolacrimais de coelhos. Para isso, utilizaram-se 20 coelhos adultos da raça Nova Zelândia, machos e fêmeas, com peso de 3,2±0,4kg, distribuídos em dois grupos: oclusão com n-butil cianoacrilato (GB, n=10) e oclusão com 2-octil cianoacrilato (GO, n=10). Os olhos contralaterais foram utilizados como controle. A permanência da lágrima foi avaliada diariamente pelo teste de Schirmer I. Foram avaliados o desconforto, secreção ocular, epífora e hiperemia conjuntival, previamente ao procedimento (T0) e durante 14 dias (T1-T14). Aos sete e aos 14 dias, cinco animais de cada grupo foram submetidos à eutanásia, e os dutos

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Comparison of 2-octyl cyanoacrylate adhesive, fibrin glue, and suturing for wound closure in the porcine urinary tract

Cited by 50 publications

References 18 publications

Temporary occlusion of the inferior lacrimal punctum and canaliculi of dogs with n-butyl-cyanoacrylate and 2-octyl-cyanoacrylate

Temporary occlusion of the inferior lacrimal punctum and canaliculi of dogs with n-butyl-cyanoacrylate and 2-octyl-cyanoacrylate

Pharmacokinetics on a microscale: visualizing Cy5-labeled oligonucleotide release from poly(n-butylcyanoacrylate) nanocapsules in cells

Clinical and histological effects of the temporary occlusion of the rabbit nasolacrimal duct and point using cyanoacrylate adhesives

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