Comparison of 2-Octyl Cyanoacrylate Topical Skin Adhesive and Simple Interrupted Nylon Sutures for Wound Closure in Ankle Fracture Surgery

Park, Young Hwan; Song, Jong Hyub; Choi, Gi Won; Kim, Soo Hyun

doi:10.1177/1071100718786166

Cited by 10 publications

(12 citation statements)

References 32 publications

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“…This is in contrast to a number of other studies in both orthopedic and other surgical specialty settings, which report that application of TSA is quicker than suturing. 21,22 Given this time difference is a very small percentage of the overall operative time, we do not think this finding is clinically relevant. A number of studies report concerns over wound dehiscence 3 and inflammation when using TSA, which was also found in this study.…”

Section: Discussionmentioning

confidence: 91%

“…There is extremely limited evidence regarding the use of TSA vs sutures in foot and ankle surgery. Park et al 22 retrospectively investigated the use of topical skin adhesive compared to nylon sutures in ankle fracture surgery and found that use of TSA was quicker and had higher patient satisfaction rates, although there was a higher (but not statistically significant) increase in wound dehiscence. Park et al 21 also retrospectively reviewed sutures vs TSA in Achilles tendon surgery and found no difference in wound complications, but they did find operating time significantly longer with sutures and patient satisfaction significantly higher with TSA.…”

Section: Discussionmentioning

confidence: 99%

“…cosmesis as well as potentially reduced operative time and infection rate due to immediate sealing of the wound. 6,10,21,22,24 The use of topical skin adhesive has been explored in both elective and trauma orthopedic surgery subspecialties. 3,9,10,13,15,19,22,26 Unfortunately, there are often a number of methodological issues with bias, small sample sizes, study design, and few prospective randomized studies, particularly in orthopedics.…”

mentioning

confidence: 99%

“…6,10,21,22,24 The use of topical skin adhesive has been explored in both elective and trauma orthopedic surgery subspecialties. 3,9,10,13,15,19,22,26 Unfortunately, there are often a number of methodological issues with bias, small sample sizes, study design, and few prospective randomized studies, particularly in orthopedics. There is a gap in the literature regarding the use of topical skin adhesive for forefoot surgery despite its routine use in clinical practice.…”

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confidence: 99%

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Randomized Controlled Trial of Topical Skin Adhesive vs Nylon Sutures for Incision Closure in Forefoot Surgery

et al. 2021

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Background: There are many options for incision closure in forefoot surgery. The aim of this study was to compare topical skin adhesive (2-octyl-cyanoacrylate) to simple interrupted nylon sutures. Methods: A prospective randomized controlled trial comparing topical skin adhesive (TSA) and nylon sutures (NSs) for elective open forefoot surgery. Primary outcome was Hollander Wound Evaluation Scale (HWES) assessed 2 weeks following surgery. Secondary objectives included time taken for wound closure, wound assessment, patient satisfaction with wound cosmesis, incision pain, and infection rate. Results: Between January and December 2018, 84 feet (70 patients) underwent hallux valgus scarf/Akin osteotomy or first metatarsophalangeal arthrodesis and were randomized to receive either intervention (topical skin adhesive) or control (3/0 nylon sutures). We found worse HWES scores when using TSA compared to NSs (1.07 vs 0.60). Incision closure time was slower for TSA (mean, 272 vs 229 seconds). At 2 weeks postoperatively, wound care was faster for TSA (mean 71 secs) vs NSs (mean 120), and patient-reported pain was less with TSA (visual analog scale: TSA 1.2 vs NSs 2.1). A high degree of overall patient satisfaction was reported in both groups, without significant difference. Conclusion: Closure of elective forefoot surgery incisions with topical skin adhesive or interrupted nylon sutures offers high satisfaction rates, low pain scores, and low complications. However, topical skin adhesive was associated with more inflammation and areas of wound separation compared to nylon sutures. We recommend the use of sutures for wound closure in forefoot surgery. Level of Evidence: Level I, randomized controlled trial.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Randomized Controlled Trial of Topical Skin Adhesive vs Nylon Sutures for Incision Closure in Forefoot Surgery

et al. 2021

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“…[4][5][6] For this reason, topical skin adhesives, which have the advantages of good scar cosmesis, infection prevention, easy skill acquisition, and lack of need for dedicated removal have begun to attract attention. [7][8][9][10][11][12][13] Liquid 2-octyl cyanoacrylate and n-butyl cyanoacrylate monomers are commonly used ingredients for topical skin adhesives because they polymerize into solid chains upon contact with the wound surface and hold wound edges together. 14 Although 2-octyl cyanoacrylate and n-butyl cyanoacrylate are harmless to most patients, they can act as allergens and cause allergic contact dermatitis (ACD).…”

Section: Introductionmentioning

confidence: 99%

Incidence and Risk Factor of Allergic Contact Dermatitis to 2-Octyl Cyanoacrylate and n-Butyl Cyanoacrylate Topical Skin Adhesives

Park

Choi

et al. 2021

Preprint

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Although the use of topical skin adhesives has increased as an alternative to conventional skin closure methods, studies on the incidence and risk factors of allergic contact dermatitis (ACD) to topical skin adhesives have been limited. The purpose of this study was to investigate the incidence and risk factors of ACD after the use of 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives. We retrospectively reviewed 1145 patients (739 patients with 2-octyl cyanoacrylate and 406 patients with n-butyl cyanoacrylate) who underwent skin closure with topical skin adhesives. Variables suspected to correlate with ACD were retrieved from medical records and analyzed to determine risk factors. The incidence of ACD from the use of 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives was 2.7% and 2.2%, respectively. There was no statistically significant difference in the incidence between the two ingredients. In logistic regression analysis, none of the variables were found to increase the risk of ACD in both 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives. As ACD occurs without risk factors in 2–3% of patients who used 2-octyl cyanoacrylate or n-butyl cyanoacrylate topical skin adhesives, clinicians and patients should be aware of these facts before using topical skin adhesives.

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First‐Aid Hydrogel Wound Dressing with Reliable Hemostatic and Antibacterial Capability for Traumatic Injuries

Cheng,

Wang,

Gao

et al. 2023

Adv Healthcare Materials

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First‐aid for severe traumatic injuries in the battlefield or pre‐hospital environment, especially for skin defects or visceral rupture, remains a substantial medical challenge even in the context of the rapidly evolving modern medical technology. Hydrogel‐based biomaterials are highly anticipated for excellent biocompatibility and bio‐functional designability. Yet, inadequate mechanical and bio‐adhesion properties limit their clinical application. To address these challenges, a kind of multifunctional hydrogel wound dressing is developed with the collective multi‐crosslinking advantages of dynamic covalent bonds, metal−catechol chelation, and hydrogen bonds. The mussel‐inspired design and zinc oxide‐enhanced cohesion strategy collaboratively reinforce the hydrogel's bio‐adhesion in bloody or humoral environments. The pH‐sensitive coordinate Zn2+‐catechol bond and dynamic Schiff base with reversible breakage and reformation equip the hydrogel dressing with excellent self‐healing and on‐demand removal properties. In vivo evaluation in a rat ventricular perforation model and Methicillin‐resistant Staphylococcus aureus (MRSA)‐infected full‐thickness skin defect model reveal excellent hemostatic, antibacterial and pro‐healing effectiveness of the hydrogel dressing, demonstrating its great potential in dealing with severe bleeding and infected full‐thickness skin wounds.

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Comparison of 2-Octyl Cyanoacrylate Topical Skin Adhesive and Simple Interrupted Nylon Sutures for Wound Closure in Ankle Fracture Surgery

Abstract: Level III, retrospective comparative study.

Cited by 10 publications

References 32 publications

Randomized Controlled Trial of Topical Skin Adhesive vs Nylon Sutures for Incision Closure in Forefoot Surgery

Randomized Controlled Trial of Topical Skin Adhesive vs Nylon Sutures for Incision Closure in Forefoot Surgery

Incidence and Risk Factor of Allergic Contact Dermatitis to 2-Octyl Cyanoacrylate and n-Butyl Cyanoacrylate Topical Skin Adhesives

First‐Aid Hydrogel Wound Dressing with Reliable Hemostatic and Antibacterial Capability for Traumatic Injuries

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