Comparison of 24 different adjuvants for inactivated HIV-2 split whole virus as antigen in mice. Induction of titres of binding antibodies and toxicity of the formulations

Stieneker, F; Kersten, Gideon; Bloois, Louis van; Crommelin, Daan J.A.; Hem, Stanley L.; Löwer, Johannes; Kreuter, Jörg

doi:10.1016/0264-410x(95)80010-b

Cited by 41 publications

(24 citation statements)

References 45 publications

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“…61) Biodegradable polymeric nanoparticles, typically consisting of polylactic acid (PLA), polyglycolic acid (PGA), polylactic-glycolic acid (PLGA), and polymethyl methacrylate (PMMA) are being investigated for the delivery of proteins, genes and DNA. [62][63][64][65] PLGA Poly-(D,L-lactic-co-glycolic acid) based nanoparticles have also proven their ability in enhanced delivery of antigens to dendritic cells. 66) Biodegradable polymeric nanoparticles offer an effective oral vaccine delivery system with an increased IgA antibody response and thus hold promise for oral vaccination.…”

Section: Solid Lipid Nanoparticles (Sln)mentioning

confidence: 99%

Nanocarriers: Promising Vehicle for Bioactive Drugs

Rawat

Singh

Saraf

2006

Biological & Pharmaceutical Bulletin

395

183

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Development of new delivery systems that deliver the potential drug specifically to the target site in order to meet the therapeutic needs of the patients at the required time and level remains the key challenge in the field of pharmaceutical biotechnology. Developments in this context to achieve desired goal has led to the evolution of the multidisciplinary field nanobiotechnology which involves the combination of two most promising technologies of 21st century-biotechnology and nanotechnology. Nanobiotechnology encompasses a wide array of different techniques to improve the delivery of biotech drugs, and nanoparticles offer the most suitable form whose properties can be tailored by chemical methods. This review highlights the different types of nanoparticulate delivery systems employed for biotech drugs in the field of molecular medicine with a short overlook at its applications and the probable associated drawbacks.

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Section: Solid Lipid Nanoparticles (Sln)mentioning

confidence: 99%

Nanocarriers: Promising Vehicle for Bioactive Drugs

Rawat

Singh

Saraf

2006

Biological & Pharmaceutical Bulletin

395

183

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“…The LD 50 for intravenously administered Quil A is 0.67 mg/kg in rats [55] and doses of greater than 25 µg of Quil A given intraperitoneally can be toxic in the B 6 D 2 F 1 strain of mice [56]. Lethality in other strains of mice has also been reported with intraperitoneal or subcutaneous doses of ISCOMs containing from 10 to 50 µg of Quil A [7,34,57]. When examined at autopsy, mice showed liver degeneration [7].…”

Section: Toxicity Of Saponins Iscoms and Iscom Matrixmentioning

confidence: 99%

ISCOMs: an adjuvant with multiple functions

Sjölander

Cox

Barr

1998

Journal of Leukocyte Biology

158

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“…Polymethacrylic-acid-based nanoparticles were shown to be effective as adjuvants for inactivated HIV-2 antigen compared with several other conventional adjuvants, including alum and Freund's adjuvant [108]. They have been reported to enhance immune responses against different antigens, including influenza virus and bovine serum albumin [36].…”

Section: Polymethacrylatesmentioning

confidence: 99%

Applications of polymeric adjuvants in studying autoimmune responses and vaccination against infectious diseases

Shakya

Nandakumar

2013

J. R. Soc. Interface.

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Polymers as an adjuvant are capable of enhancing the vaccine potential against various infectious diseases and also are being used to study the actual autoimmune responses using self-antigen(s) without involving any major immune deviation. Several natural polysaccharides and their derivatives originating from microbes and plants have been tested for their adjuvant potential. Similarly, numerous synthetic polymers including polyelectrolytes, polyesters, polyanhydrides, non-ionic block copolymers and external stimuli responsive polymers have demonstrated adjuvant capacity using different antigens. Adjuvant potential of these polymers mainly depends on their solubility, molecular weight, degree of branching and the conformation of polymeric backbone. These polymers have the ability not only to activate humoral but also cellular immune responses in the host. The depot effect, which involves slow release of antigen over a long duration of time, using different forms (particulate, solution and gel) of polymers, and enhances the co-stimulatory signals for optimal immune activation, is the underlying principle of their adjuvant properties. Possibly, polymers may also interact and activate various toll-like receptors and inflammasomes, thus involving several innate immune system players in the ensuing immune response. Biocompatibility, biodegradability, easy production and purification, and non-toxic properties of most of the polymers make them attractive candidates for substituting conventional adjuvants that have undesirable effects in the host.

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Comparison of 24 different adjuvants for inactivated HIV-2 split whole virus as antigen in mice. Induction of titres of binding antibodies and toxicity of the formulations

Cited by 41 publications

References 45 publications

Nanocarriers: Promising Vehicle for Bioactive Drugs

Nanocarriers: Promising Vehicle for Bioactive Drugs

ISCOMs: an adjuvant with multiple functions

Applications of polymeric adjuvants in studying autoimmune responses and vaccination against infectious diseases

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