Comparison of 50 μg and 25 μg doses of intrathecal morphine on postoperative analgesic requirements in patients undergoing transurethral resection of the prostate with intrathecal anesthesia

Duman, Ateş; Apilioğulları, Seza; Balasar, Mehmet; Gürbüz, Recai; Karcioglu, Murat

doi:10.1016/j.jclinane.2009.09.006

Cited by 11 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intrathecal 50 μg morphine has been associated with good perioperative analgesia and patient satisfaction in previous studies. [1112] The use of this small dose in the present series resulted in the prevention of PDPH without any opioid-related complications.…”

Section: Discussionmentioning

confidence: 86%

Intrathecal catheterisation for accidental dural puncture: A successful strategy for reducing post-dural puncture headache

et al. 2014

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 86%

Intrathecal catheterisation for accidental dural puncture: A successful strategy for reducing post-dural puncture headache

et al. 2014

View full text Add to dashboard Cite

“…Ozbek et al (14) found that postoperative analgesic requirement was reduced in patients undergoing (transurethral resection of the prostate) TURP with spinal anesthesia who received 150 μg intrathecal morphine versus those who received 75 μg intrathecal morphine. Duman et al (15) reported that in patients undergoing TURP, intrathecal morphine at a dose of 25 μg provides sufficient postoperative analgesia similar to a dose of 50 μg.In this study, it was observed that the time for the first analgesic requirement in the intrathecal morphine group was approximately two hours longer than the group without morphine. However, there was no difference between the 50 μg and 100 μg intrathecal morphine groups.…”

Section: Discussionmentioning

confidence: 99%

The effect of adding morphine to intratecal bupivacaine on postoperative analgesia in patients with perianal surgery

Babayiğit¹

2021

Anatolian Current Medical Journal

View full text Add to dashboard Cite

Aim: Pain is the major problem in early postoperative period after anorectal operations. In this study, we aimed to evaluate the first analgesic requirement time and complications of intrathecal 5 mg hyperbaric bupivacaine, intrathecal 5 mg hyperbaric bupivacaine with intrathecal 50 μg and 100 μg of morphine combinations in anorectal surgery. Material and Method: A total of 60 patients divided into 3 groups, including 20 patients in each group, were included for the study;Group 1: 5 mg 0.5% heavy bupivacaine (HB), Group 2: 5 mg 0.5% HB and 50 μg Morphine,Group 3: 5 mg 0.5% HB and 100 μg Morphine was intrathecally administered. Intraoperative and postoperative hemodynamics, time to urination and first analgesia requirement, perioperative and postoperative side effects were recorded Results: The time to first analgesic requirement in Group 1 (305.40±143.86) was statistically significantly lower than Group 2 (435.50±171.70) and Group 3 (435.50±156.08) (p=0.015). No significant difference was found between urinary retention (p>0.05). It was determined that the postoperative nausea and vomiting percentages (25.0%) in Group 3 were statistically significantly higher than Group 2 (5.0%) and Group 1 (0.0%) (p<0.05). Conclusions: The use of 50 μg of intrathecal morphine in patients undergoing anorectal surgery in saddle block anesthesia has the expected effect on postoperative analgesia and for this reason it is considered appropriate to be preferred in anorectal surgery thus to the minimal adverse side effects.

show abstract

“…Therefore, intrathecal morphine 100 µg seems to be an appropriate and preferable dose. Duman et al [11] compared 25 µg and 50 µg doses of intrathecal morphine on postoperative analgesic requirements in patients undergoing TURP with spinal anesthesia. However, the results of the study by Duman et al [11] revealed that 31-36% of patients experienced pain and the mean postoperative pain scores were still high at postoperative 12 hour.…”

Section: Discussionmentioning

confidence: 99%

“…At least T10 dermatome is required in TURP procedures. Lower doses of bupivacaine were used for spinal anesthesia in some studies [11,12], in which, however, adequate level of sensory block could not be obtained. Spinal anesthesia is preferred to general anesthesia in TURM procedures since it allows early diagnosis of severe complications such as fluid overload and bladder perforation.…”

Section: Discussionmentioning

confidence: 99%

“…However, morphine 1 mg caused a considerable increase in the incidence of side effects. Succeeding investigators studied lower doses of intrathecal morphine in patients undergoing TURP and reported that effective analgesia could be achieved with doses below 200 µg without causing severe respiratory depression [3,10,11]. Patients report postoperative pain and distress after TURB especially due to the presence of urinary catheter.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Efficacy of Intrathecal Morphine With Bupivacaine For Postoperative Analgesia After TUR-B

Incesu

Deni̇z

Erhan

et al. 2020

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

View full text Add to dashboard Cite

Bu randomize çalışmada transüretral mesane rezeksiyonu (TUR-M) sonrası analjezi için bupivakain ile iki farklı intratekal (IT) morfin dozu değerlendirildi. Gereç ve Yöntem: Yetmiş beş hasta rastgele üç gruba ayrıldı. IT morfin (100 ug) ile 12,5 mg %0,5 bupivakain (1. Grup), IT morfin (200 ug) ile 12,5 mg %0,5 bupivakain (2. Grup) ve morfinsiz IT 12,5 mg %0,5 bupivakain (3. Grup) alanlar olarak. Postoperatif ağrı 24 saat boyunca VAS ile değerlendirildi ve ağrı şiddeti orta derecede olan her hastaya intravenöz parasetamol ve Dexketoprophen trometamol verildi. Bulgular: Grup I ve II'de VAS skorları 1 saat, 2 saat, 4 saat, 6 saat, 12 saatte Grup III'e göre anlamlı olarak düşüktü (p<0.05). Analjezi talebi Grup III'te diğer iki gruba göre anlamlı derecede yüksekti (p< 0.05). Grup II'de postoperatif bulantı, diğer iki gruba göre daha fazla rapor edildi (p<0.05). Sonuç: IT %12,5 mg %0,5 bupivakain ile morfin (100 ug ve 200 ug), yanlız IT %12,5 mg %0,5 bupivakain'e kıyasla postoperatif ağrı skorlarında anlamlı bir azalma sağladı. TUR-M sonrasında postoperatif ağrı kontrolünde IT 100 ug morfin, IT 200 ug morfinden önemli ölçüde karşılaştırılabilir daha düşük yan etkiler sağladı.

show abstract

Comparison of 50 μg and 25 μg doses of intrathecal morphine on postoperative analgesic requirements in patients undergoing transurethral resection of the prostate with intrathecal anesthesia

Cited by 11 publications

References 16 publications

Intrathecal catheterisation for accidental dural puncture: A successful strategy for reducing post-dural puncture headache

Intrathecal catheterisation for accidental dural puncture: A successful strategy for reducing post-dural puncture headache

The effect of adding morphine to intratecal bupivacaine on postoperative analgesia in patients with perianal surgery

The Efficacy of Intrathecal Morphine With Bupivacaine For Postoperative Analgesia After TUR-B

Contact Info

Product

Resources

About