Comparison of adenosine 5'-monophosphate and methacholine for the differentiation of asthma from chronic airway diseases with the use of the auscultative method in very young children

Avital, Avraham; Picard, Elie; Uwyyed, Kamal; Springer, Chaim

doi:10.1016/s0022-3476(95)70079-x

Cited by 32 publications

(34 citation statements)

References 9 publications

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“…Little is known about AHR in postinfectious BO. Two studies [7,8] have shown that children with asthma and those with chronic lung diseases (cystic fibrosis, ciliary dyskinesia and BO) have AHR to methacholine, but only those with asthma are hyperreactive to AMP. However, because of the small number of cases involved and the undefined aetiology of BO, the results are inconclusive concerning response to methacholine and AMP in postinfectious BO.…”

Section: Discussionmentioning

confidence: 99%

“…Methacholine acts directly at the level of bronchial smooth muscle, whereas adenosine 59-monophosphate (AMP) acts indirectly, causing primed mast cell degranulation and the release of pro-inflammatory mediators [6]. It has been shown that AHR to methacholine is present both in asthma and in chronic lung diseases, whereas AHR to AMP is present only in asthma [7,8]. However, to the current authors' knowledge, these two types of bronchial challenge have never been compared in patients presenting with a diagnosis of post-infectious BO.…”

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confidence: 99%

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Methacholine and adenosine 5′-monophosphate challenges in children with post-infectious bronchiolitis obliterans

Yoo

Kim

et al. 2006

Eur Respir J

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Airway hyperresponsiveness (AHR) is a characteristic feature of asthma, but is also frequently demonstrated by children and adults with chronic obstructive lung diseases. AHR is usually measured by bronchial challenges using direct or indirect stimuli. The aim of this study was to compare these two types of bronchial challenge in children with post-infectious bronchiolitis obliterans (BO).Methacholine and adenosine 59-monophosphate (AMP) challenges were used as tools for the evaluation of AHR to direct and indirect stimuli, respectively, in children with post-infectious BO (n528). These results were compared with those of asthmatic (n530) and control children (n525).Altogether, twenty-two patients (78.6%) with post-infectious BO were hyperreactive to methacholine with a provocative concentration causing a 20% fall in forced expiratory volume in one second (PC20) of ,16 mg?mL -1 , but only six (21.4%) were hyperreactive to AMP with a PC20of ,200 mg?mL -1. All patients with asthma responded positively to methacholine, and most (28, 93.3%) also responded positively to AMP. The majority of controls were insensitive to both challenges.Airway hyperresponsiveness to methacholine is a frequent, but by no means universal, finding in children with post-infectious bronchiolitis obliterans, but is usually not accompanied by airway hyperresponsiveness to adenosine 59-monophosphate. This finding suggests that airway hyperresponsiveness in patients with post-infectious bronchiolitis obliterans has characteristics that differ from those of asthmatic subjects.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Methacholine and adenosine 5′-monophosphate challenges in children with post-infectious bronchiolitis obliterans

Yoo

Kim

et al. 2006

Eur Respir J

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“…Therefore, the use of indirect challenge tests has been encouraged (2)(3)(4). Other indirect challenge tests, such as inhalation of adenosine (2,38) or mannitol (39), may be interesting candidates of even simpler tests for BHR in young children with asthma in future studies.…”

Section: Discussionmentioning

confidence: 99%

Hyperventilation with Cold versus Dry Air in 2- to 5-Year-Old Children with Asthma

Nielsen¹,

Bisgaard²

2005

Am J Respir Crit Care Med

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“…BPT was performed by inhalation of AMP solutions in doubling doses [17]. Fresh solutions of AMP (SIGMA, St. Louis, MO, USA) were prepared, starting at 0.39 mg?mL -1 to a maximum of 400 mg?mL -1 .…”

Section: Adenosine Bronchial Provocationmentioning

confidence: 99%

Wheeze monitoring in children for assessment of nocturnal asthma and response to therapy

Bentur

Beck

Shinawi³

et al. 2003

Eur Respir J

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The utilisation of nocturnal wheeze monitoring and quantification for assessment of asthma activity was studied in symptomatic school-aged children before and during treatment.Twelve children 6-14 yrs of age with mild or moderate untreated asthma were studied at home three times: before, 48 h and 6 weeks into treatment with 5 mg montelukast daily. Lung sounds were recorded overnight by an automatic wheeze detection device (PulmoTrack1). Per cent wheezing within each respiratory cycle was calculated every 30 s throughout the night and a Nocturnal Wheeze Index (NWI) was calculated for the total night. The results were compared with spirometric indices (forced expiratory volume in one second (FEV1), forced vital capacity), bronchial reactivity (provocative concentration causing a 20% fall in FEV1 by adenosine 59-monophosphate (PC20)) and daily symptom scores, performed in parallel at each stage of the study.The pretreatment NWI was 814¡898 (mean¡SD), which declined to 318¡199 2 days after onset, and to 137¡101 after 6 weeks of treatment. The NWI in seven healthy children was 47¡43. The FEV1, PC20 and symptom scores improved in parallel.Wheeze monitoring provides quantitative and noninvasive information about the extent of nocturnal wheezing in children, correlates well with conventional indices of asthma activity and can assist in assessing efficacy of treatment. Eur Respir J 2003; 21: 621-626.

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Comparison of adenosine 5'-monophosphate and methacholine for the differentiation of asthma from chronic airway diseases with the use of the auscultative method in very young children

Cited by 32 publications

References 9 publications

Methacholine and adenosine 5′-monophosphate challenges in children with post-infectious bronchiolitis obliterans

Methacholine and adenosine 5′-monophosphate challenges in children with post-infectious bronchiolitis obliterans

Hyperventilation with Cold versus Dry Air in 2- to 5-Year-Old Children with Asthma

Wheeze monitoring in children for assessment of nocturnal asthma and response to therapy

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