Comparison of adjuvant and streptococcal cell wall-induced arthritis in the rat

IKKβ inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis

“…Rat adjuvant‐induced arthritis has been widely used as an experimental model for preclinical screening of treatments for RA. The model system is robust, the incidence rate for the disease is 100%, and adjuvant‐induced arthritis in rats shares many features with RA in humans, such as inflammation, marked bone resorption, and periosteal bone proliferation (41–43). The aggressive nature of rat adjuvant‐induced arthritis, however, must be considered when compared with RA in humans.…”

“…We included dexamethasone as a standard control in our studies because its dramatic effects on arthritis in rat models are well established (41–43). Despite the potent antiinflammatory action of this steroid, however, patients experience too many dose‐dependent side effects (9), as predicted in both the adjuvant‐induced and the collagen‐induced models of arthritis (42).…”

“…Protection against adjuvant‐induced arthritis in rats has been achieved by blocking NF‐κB activity using a dominant‐negative mutant of IKKβ, providing strong validation for the role of IKKβ in this model (44). In addition, in the adjuvant‐induced arthritis model, rats exhibit marked bone resorption and new bone formation; therefore, this model allows for the assessment of these features perhaps better than other models of arthritis in rodents, such as collagen‐induced or streptococcal cell wall–induced arthritis (41–43). Two other groups of investigators have reported that IKKβ‐specific inhibitors show efficacy in mouse models of collagen‐induced arthritis, but neither of those reports addressed protection against bone destruction (45, 46).…”

Selective Downregulation of Hepatic Cytochrome P450 Expression and Activity in a Rat Model of Inflammatory Pain

“…When FCA is administered into the joint or at the tail base, acute inflammation progresses slowly to a complex arthritis-like stage in 14 days or more postinjection (6). This FCA-induced arthritis has been recognized to decrease total P450 contents in rat liver (7).…”

A new spin on an old model: In vivo evaluation of disease progression by magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat

“…Since the discovery and subsequent characterization of rat adjuvant-induced arthritis (AIA) by Stoerk et al (1) and Pearson (2) over 40 years ago, AIA has proven to be a reliable, reproducible, and predictive animal model for studying inflammatory and immunologic mechanisms contributing to human rheumatoid arthritis (RA) (3), and for evaluating potential therapeutic interventions (3)(4)(5)(6)(7). Pearson (2) and Ward and Jones (8) were the first to histologically describe the acute and chronic synovitis and periostitis associated with rat AIA.…”