Comparison of adverse events between cervical disc arthroplasty and anterior cervical discectomy and fusion: a 10-year follow-up

Loidolt, Travis; Kurra, Swamy; Riew, K. Daniel; Levi, Allan D.; Florman, Jeffrey E.; Lavelle, William F.

doi:10.1016/j.spinee.2020.10.013

Cited by 35 publications

(25 citation statements)

References 30 publications

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“…Cervical disc arthroplasty can achieve favorable clinical and radiographic outcome in previous literature [ 2 , 3 , 8 , 18 , 19 ]. A meta-analysis indicated that cervical disc arthroplasty was an effective and safe surgical technique, and it was found to be more superior to ACDF in terms of better neurological function, lower neck pain scores at 2 years follow-up [ 7 ].…”

Section: Discussionmentioning

confidence: 97%

Influence of the deviated center of rotation on the range of motion after cervical disc arthroplasty –an in vivo study with a minimum of 10-year follow-up

Shi

et al. 2023

BMC Musculoskelet Disord

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Background Short-term researches have studied the change of the center of rotation (COR) after the Bryan Cervical disc arthroplasty (CDA). But there is a lack of long-term studies focusing on the location of COR and its influence after surgery. Methods Clinical and radiographic materials of patients who received CDA were retrospectively reviewed. Written informed consents were obtained. Clinical outcome was accessed by Japanese Orthopaedic Association (JOA), Neck Disability Index (NDI), and Odom’s scale. Radiographic evaluation underwent before surgery, at early (3 months) follow-up and final (minimal 10 years) follow-up. The ROM of the global cervical spine and index level, the functional spine unit (FSU) angle and C2-C7 angle were measured. COR was identified and its coordinates were calculated. The absolute change of COR-x and COR-y were compared in subgroup analysis. Results Sixty patients were included, with an average age of 55.9 ± 8.1 years old. The mean duration of follow up was 135.1 ± 16.1 (120–155) months. JOA, NDI and Odom’s scale showed significant improvements at 10 years after surgery. The COR of index level was located in the posterior superior half of the caudal vertebral body. Following the implant of Bryan Disc, the COR shifted forward and downward. During the 10-year follow-up, the location of COR remained stable. ROM at the index level decreased from 10.6 ± 4.0° preoperatively to 9.3 ± 4.0° at the early follow-up (p = 0.03). The ROM at the index level remained unchanged from early follow-up to the final follow-up (9.3 ± 4.0° vs 9.5 ± 5.2°, p = 0.80). In subgroup analysis, larger changes of both COR-x and COR-y were related with decreased ROM. Conclusions Our study illustrated that Bryan CDA could achieved favorable clinical and radiographic outcome over a minimal 10-year follow-up. The reduction of the flexion-extension ROM may be correlated with a more deviated postoperative COR. More attention should be paid to preoperative design and intraoperative technique to obtain a more native COR.

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Section: Discussionmentioning

confidence: 97%

Influence of the deviated center of rotation on the range of motion after cervical disc arthroplasty –an in vivo study with a minimum of 10-year follow-up

Shi

et al. 2023

BMC Musculoskelet Disord

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“…The 10-year Investigational Device Exemption (IDE) trial data for the Bryan and Mobi-C cervical disc arthroplasty devices are now available. In a study comparing adverse events between the Bryan cervical disc arthroplasty and ACDF, Loidolt et al demonstrated a similar rate of adverse events over a 10year period 7 . The rate of revision surgery at the index level was not significantly different between the 2 groups.…”

Section: Cervical Radiculopathymentioning

confidence: 90%

What’s New in Spine Surgery

Helgeson

Pisano

Wagner

2022

Journal of Bone and Joint Surgery

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“…Implantation of an exogenous artificial cervical disc and the operation itself destroy the original cervical structure and stability to a certain extent, resulting in possible neurological symptoms after surgery ( Loidolt et al, 2021 ). MRI can sensitively detect implantation-related complications such as degeneration, ASD, and spinal cord compression caused by prosthesis displacement and heterotopic ossification.…”

Section: Discussionmentioning

confidence: 99%

Cervical subtotal discectomy prosthesis validated in non-human primate model: A novel artificial cervical disc replacement concept?

Liu

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

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Objective: To evaluate the biological function of cervical subtotal discectomy prosthesis (CSDP) implantation in a non-human primate model.Methods: A CSDP was tested for cytocompatibility and osseointegration capacity before implantation in non-human primates. Subsequently, the CSDP was improved based on three-dimensional CT measurements of the non-human primate cervical spine. Eight cynomolgus monkeys were selected for removal of the intervertebral disc and lower endplate of the C5/6 segment to complete the model construction for CSDP implantation. In 18-month follow-up, physiological indices, radiology, and kinematics were assessed to estimate the biological function of the CSDP in non-human primates, including biosafety, osseointegration, and biomechanics.Results: Co-cultured with the CSDP constituent titanium alloy (Ti6Al4V-AO), the mouse embryo osteoblast precursor cell MC3T3-E1 obtained extended adhesion, remarkable viability status, and cell proliferation. After implantation in the mouse femur for 28 days, the surface of Ti6Al4V-AO was covered by a large amount of new cancellous bone, which formed further connections with the femur cortical bone, and no toxicity was detected by blood physiology indices or histopathology. After completing implantation in primate models, no infection or osteolysis was observed, nor was any subsidence or displacement of the CSDP observed in CT scans in the 18-month follow-up. In particular, the interior of the cervical vertebra fixation structure was gradually filled with new trabecular bone, and the CSDP had achieved fixation and bony fusion in the vertebral body at 1 year post-operation. Meanwhile, no signs of inflammation, spinal cord compression, adjacent segment degeneration, or force line changes were observed in subsequent MRI observations. Moreover, there were no pathological changes of the joint trajectory, joint motion range, stride length, or the stance phase ratio revealed in the kinematics analysis at 3, 6, 12, or 18 months after CSDP implantation.Conclusion: We successfully designed a new cervical subtotal discectomy prosthesis and constructed an excellent non-human primate implantation model for the evaluation of subtotal disc replacement arthroplasty. Furthermore, we demonstrated that CSDP had outstanding safety, osseointegration capacity, and biomechanical stability in a non-human primate model, which might be a new choice in the treatment of cervical disc diseases and potentially change future outcomes of degenerative cervical diseases.

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Comparison of adverse events between cervical disc arthroplasty and anterior cervical discectomy and fusion: a 10-year follow-up

Cited by 35 publications

References 30 publications

Influence of the deviated center of rotation on the range of motion after cervical disc arthroplasty –an in vivo study with a minimum of 10-year follow-up

Influence of the deviated center of rotation on the range of motion after cervical disc arthroplasty –an in vivo study with a minimum of 10-year follow-up

What’s New in Spine Surgery

Cervical subtotal discectomy prosthesis validated in non-human primate model: A novel artificial cervical disc replacement concept?

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