Comparison of Analgesic Effects between Nalbuphine and Sufentanil in First-Trimester Surgical Abortion: A Randomized, Double-Blind, Controlled Trial

Abstract

Introduction: Surgical abortion is one of the commonly conducted procedures worldwide. Nevertheless, pregnant women still complain of procedural and postoperative pain despite the use of advanced anesthesia. It is vital to women's reproductive healthcare to improve postsurgical pain management to achieve the lowest level of pain. Methods: This randomized, double-blind, parallel-controlled clinical trial compared the analgesic effects between nalbuphine and sufentanil in patients who underwent first-trimester surgical abortion. In total, 224 patients were allocated randomly into (a) the sufentanil group that received sufentanil (0.1 ug/kg) combined propofol, and (b) the nalbuphine group that received nalbuphine (0.1 mg/kg) combined propofol. Postoperative pain scores, propofol injection pain, intraoperative analgesic effect, adverse events, and degree of satisfaction were recorded as outcome measures. Results: The pain scores in the nalbuphine group were lower than those in the sufentanil group at 15 min, 30 min, 1 h, and 6 h after surgical abortion. In addition, the incidence and intensity of propofol injection pain were lower in the nalbuphine group. The degree of satisfaction of the patients in the nalbuphine group was higher than that in the sufentanil group. The intraoperative analgesic effect, hemodynamic fluctuation, and adverse events were comparable between the two groups. Conclusions: Nalbuphine combined with propofol is superior to sufentanil combined with propofol for first-trimester abortion surgeries. Clinical Trial Registration: The trial was registered at www.chictr.org.cn, identifier ChiCTR2000040243.

Comparison of nalbuphine and propofol verses pentazocine and promethazine in tympanoplasty surgeries under monitored anesthesia care

“…These findings are also conquering with results of a similar study by Solanki et al 18 Stable hemodynamics, controlled hypotension, and decreased bleeding could be responsible for a better surgical field in Group N in our study. Intraoperative VAS pain score was lower in Group N than in Group P. 19,20 Intraoperative RSS was higher in Group N than in Group P. The findings can be explained easily by the property of propofol to reduce sympathetic activity in the body when it combines with nalbuphine (Ghali et al). 20 Although this study has compared the nalbuphine and propofol versus pentazocine and promethazine in MAC, with LA, the study was single centered.…”

Patient‐controlled intravenous administration of dexmedetomidine with nalbuphine versus sufentanil for post cesarean delivery analgesia: A retrospective observational study

“…For example, NAL at 0.128 mg/kg used in outpatient‐induced abortion as an intraoperative and postoperative analgesic showed a better effect compared with equivalent dose of SUF (0.128 μg/kg) 31 . Moreover, a randomized, double‐blind, controlled trial investigated the comparison of analgesic effects between NAL (0.1 mg/kg) and SUF (0.1 μg/kg) in first‐trimester surgical abortion 32 . Additionally, PCIA of NAL (100 mg) + ramosetron (0.3 mg) or SUF (100 μg) + ramosetron (0.3 mg) after cesarean section were compared with a previous study 33 .…”

Application of Ultrasound-Guided Transversus Abdominis Plane Block Combined with Nalbuphine Patient-Controlled Intravenous Analgesia in Postoperative Analgesia After Laparotomy: A Randomized Controlled Trial

“…Pain is an inevitable complication after surgery, which will bring great suffering to patients, cause changes in endocrine and metabolic functions of patients, delay postoperative recovery, and increase medical costs [14]. Therefore, how to relieve postoperative pain has always been a hot issue for anesthetists [22].…”

“…Nalbuphine hydrochloride (referred to as ''nalbuphine'') is a centrally acting opioid, which can activate j receptors to produce central analgesic and sedative effects; it also partially antagonizes l receptors, thereby reducing the side effects associated with activating l receptors, such as respiratory depression, nausea and vomiting, and skin itching [13]. Several studies have shown that nalbuphine has the advantages of good analgesic effect, rapid onset, long duration of action, and less incidence of adverse reactions [14]. Both nalbuphine and equivalent doses of sufentanil can provide good intraoperative and postoperative analgesia [15].…”