Comparison of antimicrobial activity between ceftolozane–tazobactam and ceftazidime–avibactam against multidrug-resistant isolates of Escherichia coli , Klebsiella pneumoniae , and Pseudomonas aeruginosa

Alatoom, Adnan; Elsayed, Hashim; Lawlor, Karen; AbdelWareth, Laila; El-Lababidi, Rania; Cardona, Lysettee; Mooty, Mohammad; Bonilla, Maria Fernanda; Nusair, Ahmad; Mirza, Imran

doi:10.1016/j.ijid.2017.06.007

Cited by 92 publications

(65 citation statements)

References 13 publications

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“…However, with VUR, when the bladder is full, the urine starts to return from the bladder through the ureter to the kidney. This deformity is common in children with urinary infections (Alatoom et al, 2017);…”

Section: Abnormalities That Can Cause Infectionmentioning

confidence: 99%

Urinary tract infections and their importance

Smieško

Mikov

Gusman

et al. 2019

Zb Mat srp prir nauk

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Urinary tract infections (UTI) are one of the most common infectious diseases, primarily caused by bacteria present in the intestinum, affecting the entire urinary tract or only a part of it. If the urinary bladder and urethra are affected then they are considered "lower" urinary tract infections, and the affected kidneys and ureter are considered "upper" urinary tract infections. There is a division into uncomplicated and complicated UTIs. Approximately 15% of all prescribed antibiotics in the United States are prescribed as therapy of UTIs. The UTI data from other countries are similar. The costs incurred in the treatment of these infections are significant -in the United States, the direct costs of UTI treatments are estimated at $ 1.6 billion per year.KEYWORDS: infections, urinary tract, bacteria PATHOGENESIS OF URINARY TRACT INFECTIONSThe urinary tract has a normal defense mechanism that protects it from infections. Urine is an adverse environment for bacterial growth due to low pH, high urea concentration, presence of organic acids, and high osmolarity. The bladder has bactericidal properties and creates an immunoglobulin A that reduces bacterial adherence to the uroepithelium. There are differences in the general and local resistance of the host to the urinary tract infections. This is the reason why some children get sick once or never, while in others the infections are often repeated, in a lighter or more severe form. The most important mechanism of defense against urinary tract infections is normal urodynamics. The disorder leads to urinary retention and the production of residual urine in which the bacteria multiply smoothly. These disorders lead to obstruction of the urinary

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Section: Abnormalities That Can Cause Infectionmentioning

confidence: 99%

Urinary tract infections and their importance

Smieško

Mikov

Gusman

et al. 2019

Zb Mat srp prir nauk

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“…Two days after the repeat chest CT, the patient was transferred to our facility for worsening pneumonia, requiring a higher level of care and CTS consultation. Abnormal clinical examination findings included diffusely diminished lung sounds, rales in the left lower lobe, a left pigtail chest tube 2,11,13,[16][17][18][19] drain, tachycardia with heart rate of 120 beats per minute, and tachypnea with a respiratory rate of 22 breaths per minute. The patient's chest tube was intact with a small amount of thick, white drainage, which was sent for culture, along with 2 sets of blood cultures.…”

Section: Case Presentationmentioning

confidence: 99%

Failure of ceftolozane‐tazobactam salvage therapy in complicated pneumonia with lung abscess

Lewis

Cluck

Tharp

et al. 2018

Clinical Case Reports

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Key Clinical MessageTreatment of Pseudomonas aeruginosa remains challenging, despite the availability ceftolozane‐tazobactam. We report a treatment failure with ceftolozane‐tazobactam salvage therapy for pneumonia complicated by lung abscess. Drug resistance, dose selection, and source control are possible contributing factors. Ceftolozane‐tazobactam susceptibility testing should precede therapy and consideration should be given to dosing selection.

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“…También se observó que, aunque las tasas de susceptibilidad son similares entre las dos combinaciones, ceftazidima/avibactam tiene CIM más bajas contra productoras de BLEE, mientras que ceftolozano/tazobactam tiene CIM más bajas contra P. aeruginosa. Frente a aislados con metalo-β-lactamasa New Dehli (NDM-1), la susceptibilidad fue muy baja para cualquiera de las dos moléculas 21 .…”

Section: Ceftolozano/tazobactamunclassified