Comparison of antimicrobial resistance patterns and phage types of Salmonella Typhimurium isolated from pigs, pork and humans in Belgium between 2001 and 2006

Boxstael, Sigrid Van; Dierick, Katelijne; Huffel, Xavier Van; Uyttendaele, Mieke; Berkvens, Dirk; Herman, Lieve; Bertrand, Sophie; Wildemauwe, Christa; Catry, Boudewijn; Butaye, Patrick; Imberechts, Hein

doi:10.1016/j.foodres.2011.05.025

Cited by 43 publications

(38 citation statements)

References 42 publications

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“…Nalidixic acid-resistant salmonellae are not common in pigs, but their numbers were low and similar in all groups, which may indicate earlier infections in suckling piglets. Serotyping of isolates also revealed S. Typhimurium DT104, which was not surprising, because this serotype and phage type dominate in pigs (19,23). Statistical calculations revealed no differences between groups in the numbers of salmonellae shed on the day of infection.…”

Section: Discussionmentioning

confidence: 91%

No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104

Janczyk

Kreuzer

Aßmus

et al. 2013

Appl Environ Microbiol

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b Twenty-eight-day-old weaned pigs were fed diets with a low (LZn), medium (MZn), or high (MZn) Zn concentration (50 to 80, 150, or 2,500 mg Zn/kg of diet, respectively) provided as zinc oxide (ZnO)(24 pigs per group). They were infected orally with Salmonella enterica serovar Typhimurium DT104 on day 32. Salmonellae were cultivated from feces (up to 42 days postinfection [dpi]) and organs (2 and 42 dpi). Activation of the adaptive systemic and mucosal immune systems was investigated by recording anti-Salmonella IgG levels and levels of B and T lymphocyte subpopulations in blood and gut-associated lymphatic tissue. Growth performance was recorded as well. Salmonellae were shed at higher levels and for longer periods in the HZn group (P < 0.05), with no differences in the tissues. At 2 dpi, the relative percentages of CD4 ؉ T helper cells (P < 0.01) and of CD2 ؉ T and NK cells (P < 0.01) in blood were reduced from the relative cell counts obtained at 0 dpi, irrespective of the Zn group. The lowest percentage of cytotoxic T cells was found 14 dpi in the HZn group relative to the MZn (P < 0.05) and LZn (P < 0.01) groups. Supplementation of the feed with 2,500 mg Zn/kg of diet immediately after weaning could positively affect the immune responses of piglets infected with Salmonella Typhimurium, but for a short period only. After 2 weeks, all positive effects disappeared, and rather negative effects, such as higher shedding of salmonellae, lower T cell frequencies, and worse performance, occurred. Thus, supplementation with ZnO at high levels in the pig industry should be limited to 2 to 3 weeks.

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Section: Discussionmentioning

confidence: 91%

No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104

Janczyk

Kreuzer

Aßmus

et al. 2013

Appl Environ Microbiol

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“…According to a study conducted in United States, the frequency of the multidrug-resistant serovar Typhimurium was reportedly increasing [48]. Besides the direct risk for human health of antimicrobialresistant Salmonella, the serovar Typhimurium represents an indirect risk in transferring resistance genes to other pathogenic bacteria through humans [13].…”

Section: Discussionmentioning

confidence: 99%

“…Most of the non-typhoidal Salmonella infections are self-limited, and do not require any antimicrobial therapy [3,4,13]. However, antibiotics are required in invasive or severe cases that may occur in some patients, particularly in vulnerable groups such as young children, the elderly, and immunocompromised persons [14].…”

Section: Introductionmentioning

confidence: 99%

Prevalence, serotype distribution, and antimicrobial resistance of Salmonella isolated from food products in Morocco

Amajoud

Bouchrif

Maadoudi

et al. 2017

J Infect Dev Ctries

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Introduction: Salmonellosis is one of the most common foodborne diseases worldwide. The irrational use of antibiotics in medicine and in animal feed has greatly promoted the emergence and spread of resistant strains of non-typhoidal Salmonella. Methodology: A total of 464 food products were collected in Tetouan from January 2010 to December 2012. The isolation and identification of Salmonella were performed according to Moroccan standard 08.0.116. All isolates were serotyped and were then tested for antibiotic resistance using the disk diffusion method. Results: The microbiological analysis showed that 10.3% of food samples were contaminated with Salmonella. Eleven serotypes were identified: Kentucky 22.9% (11/48), Agona 16.7% (8/48), Reading 12.5% (6/48), Corvallis 8.3% (4/48), Saintpaul 8.3% (4/48), Typhimurium 6.2% (3/48), Montevideo 6.2% (3/48), Enteritidis 4.2% (2/48), and 2% (1/48) for each of Israel, Hadar, and Branderup. Drug susceptibility testing showed that 39.6% of Salmonella were resistant to at least one antibiotic and 60.4% were susceptible to all tested antibiotics. The highest percentage of resistance was found to the following antimicrobial agents: nalidixic acid (27.1%), sulfonamides (25%), amoxicillin (12.5%), amoxicillin/clavulanic acid 12.5%, trimethoprim (10.4%), cephalothin (4.2%), and chloramphenicol (2.1%). Conclusions: This study revealed a relatively high prevalence of Salmonella in food products in Tetouan and a large percentage of drug-resistant strains. Hygienic measures should be rigorously implemented, and monitoring resistance of Salmonella is required to reduce the risks related to the emergence of multi-resistant bacteria.

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“…Similar results were found by Maka et al, (2014), who concluded that S. Typhimurium displayed resistance to 10 of the 19 tested compounds. Resistance to the antimicrobials ampicillin and tetracyclines was frequent for S. Typhimurium isolates from pork and poultry and varied between 23.5% and 83.1% (Glenn et al 2011;Bacci et al, 2012;Van Boxstael et al, 2012). …”

Section: Discussionmentioning

confidence: 99%

Risk characterization of antimicrobial resistance of Salmonella in meat products

et al. 2015

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Antimicrobial resistance is considered to be a major public health concern in the framework of Horizon 2020. The risk to human health from foodborne antimicrobial resistant microorganisms can be determined and assessed using risk analysis tools in accordance with Codex principles. Therefore, the objective of this work was to determine the qualitative risk characterization of the presence of Salmonella resistant strains in meat products. Consequently, a total of 2050 whole and minced samples of poultry, pork and beef, were assessed. Samples were obtained by the Official Food Control Services of the Valencian administration (Spain), in the province of Valencia between January 2006 and June 2012. Salmonella was not found in any samples of beef. Salmonella strains isolated in poultry and pork samples were not resistant to amikacin, amoxicillin, cephalothin ciprofloxacin levofloxacin and ofloxacin. However, Salmonella isolates found in poultry had a high level of resistance to nalidixic acid, while those found in pork were more resistant to tetracycline and ampicillin. Furthermore, 41% of Salmonella isolates were resistant to three or more antibiotics. Finally, considering these results as exposure and taking into account the severity of the potential adverse health effects related to the different antimicrobials, risk characterization was estimated. As a result, three cases were classified as "Very high additional risk" all of them in minced meat, two cases in poultry (gentamicin and nalidixic acid) and one in pork (ampicillin). In the rest of the cases of resistance, the risk was classified as "high additional risk". This highlights the importance of continued surveillance and the need to take measures in the primary sector in order to minimize the risk for the consumer.2

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Comparison of antimicrobial resistance patterns and phage types of Salmonella Typhimurium isolated from pigs, pork and humans in Belgium between 2001 and 2006

Cited by 43 publications

References 42 publications

No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104

No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104

Prevalence, serotype distribution, and antimicrobial resistance of Salmonella isolated from food products in Morocco

Risk characterization of antimicrobial resistance of Salmonella in meat products

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