Comparison of biofunctional activity of Asparagus cochinchinensis (Lour.) Merr. Extract before and after fermentation with Aspergillus oryzae

“…Recently, marine seaweeds have been indicated as a new generation source for natural medicines for the treatment of neurological disorders [31][32][33][34]. Fermentation tools has great attention to enhance biological functions and to increase the yield the specific substances because fermentation with microorganism splits the complex compounds into simple ones [35,36]. Fermented L. japonica extract (fLJE) shows more potent antioxidant and anti-inflammatory activities compared to that in the general LJE [37,38].…”

Section: Introductionmentioning

confidence: 99%

Physical Stress Induced Reduction of Proliferating Cells and Differentiated Neuroblasts Is Ameliorated by Fermented Laminaria japonica Extract Treatment

et al. 2020

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Laminaria japonica is widely cultivated in East Asia, including South Korea. Fucoidan, a main component of L. japonica, protects neurons from neurological disorders such as ischemia and traumatic brain injury. In the present study, we examined the effects of extract from fermented L. japonica on the reduction of proliferating cells and neuroblasts in mice that were physically (with electric food shock) or psychologically (with visual, auditory and olfactory sensation) stressed with the help of a communication box. Vehicle (distilled water) or fermented L. japonica extract (50 mg/kg) were orally administered to the mice once a day for 21 days. On the 19th day of the treatment, physical and psychological stress was induced by foot shock using a communication box and thereafter for three days. Plasma corticosterone levels were significantly increased after exposure to physical stress and decreased Ki67 positive proliferating cells and doublecortin immunoreactive neuroblasts. In addition, western blot analysis demonstrated that physical stress as well as psychological stress decreased the expression levels of brain-derived neurotrophic factor (BDNF) and the number of phosphorylated cAMP response element binding protein (pCREB) positive nuclei in the dentate gyrus. Fermentation of L. japonica extract significantly increased the contents of reduced sugar and phenolic compounds. Supplementation with fermented L. japonica extract significantly ameliorated the increases of plasma corticosterone revels and decline in the proliferating cells, neuroblasts, and expression of BDNF and pCREB in the physically stressed mice. These results indicate that fermented L. japonica extract has positive effects in ameliorating the physical stress induced reduction in neurogenesis by modulating BDNF and pCREB expression in the dentate gyrus.

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“…Additionally, with the fermented extract, the inhibition of melanin production was higher than Tyrosinase inhibition activity, suggesting that the fermented extract may downregulate not only Tyrosinase but also the Tyrosinase-related protein MITF. In contrast, the unfermented extract directly inhibited Tyrosinase activity [47,49,62]. The following table is a table listing skin-whitening agents derived from bacteria or fungi (Table 3).…”

Section: Skin-whitening Agents Derived From Bacteria or Fungimentioning

confidence: 99%

Anti-Pigmentary Natural Compounds and Their Mode of Action

Kim

Huh

Lim

2021

IJMS

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Hyper-activated melanocytes are the major cause of skin hyper-pigmentary disorders, such as freckles and melasma. Increasing efforts have been made to search for materials with depigmenting activity to develop functional cosmetics. As a result, numerous materials have been reported to have depigmenting activity but some of them are known to cause unwanted side effects. Consequently, anti-pigmentary natural compounds without concern of toxicity are in great demand. Virtually all sorts of natural sources have been investigated to find anti-pigmentary natural compounds. This review summarizes recently reported anti-pigmentary natural compounds and their mode of action from the ocean, plants, and bacteria.

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Comparison of biofunctional activity of Asparagus cochinchinensis (Lour.) Merr. Extract before and after fermentation with Aspergillus oryzae

Cited by 19 publications

References 42 publications

Submerged fermentation with Lactobacillus brevis significantly improved the physiological activities of Citrus aurantium flower extract

Submerged fermentation with Lactobacillus brevis significantly improved the physiological activities of Citrus aurantium flower extract

Physical Stress Induced Reduction of Proliferating Cells and Differentiated Neuroblasts Is Ameliorated by Fermented Laminaria japonica Extract Treatment

Anti-Pigmentary Natural Compounds and Their Mode of Action

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