Comparison of biological activities of selenium and silver nanoparticles attached with bioactive phytoconstituents: green synthesized using Spermacoce hispida extract

Abstract

Selenium and silver nanoparticles (NPs) were synthesized using Spermacoce hispida aqueous leaf extract (Sh-ALE). The optimum condition required for the synthesis of Sh-SeNPs was found to be 30 mM selenious acid solution to Sh-ALE at the ratio of 4:46, pH 9, incubated at 40 °C for 10 min. On the other hand, for Sh-AgNPs the optimum condition was found to be 1 mM AgNO3 to the Sh-ALE solution at the ratio of 4:46, pH 8, incubated at 40 °C for 10 min. SEM analysis revealed that both the Sh-AgNPs and Sh-SeNPs are predominantly rod-shaped. Sh-SeNPs and Sh-AgNPs were found to possess concentration-dependent antioxidant activity. However, Sh-SeNPs showed potent anti-inflammatory property, antibacterial property and anticancer activity against human cervical cancer cell in comparison to Sh-AgNPs. Phytochemical analysis, FTIR and GC-MS analysis showed that various flavonoids, saponins and phenolic compounds present in Sh-ALE catalysed the formation of NPs. Also, GC-MS analysis revealed that Sh-SeNPs are capped by synaptogenin B and derivatives of apigenin, quinoline and quinazoline. The advantage of attachment of such phytoconstituents on Sh-SeNPs for its potent biological activity in comparison to Sh-AgNPs is evident in in vitro conditions.

Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects

“…79 It was reported that the antioxidant potential of the plants-based SeNPs is may be due to the potential surface functional groups that cap and stabilize the nanoparticles and originate from the plant secondary metabolites. 32,62 The nutritionists and physicians routinely suggest using selenium supplemented food sources (nuts, mushrooms and cereals) to stay healthy. 13,71 The plants-based SeNPs are considered highly biocompatible in substituting the synthetic antioxidants as natural antioxidant embedding agents in food packaging material.…”

“…To overcome the serious side effects of drugs, nanobiotechnology can be a possible and effective solution to treat these deadliest diseases. 62 The plant-based SeNPs because of their non-toxic nature, excellent biocompatibility and unique bioactive properties can be one of the alternative strategies to control these devastating diseases. 5,17,41,72 In recent literature, the plant-based SeNPs have been explored to control the larva of mosquitoes.…”

“…The SeNPs were synthesized by using the Spermacoce hispida aqueous leaf extract and surface functionalized with SAG to form SAG-Sh-SeNPs. 62 Additionally, it was demonstrated that the SAG-Sh-SeNPs stimulate the ROS generation in the cancer cells. After internalization, the SAG-Sh-SeNPs might have separated into SAG and Sh-SeNPs.…”

Anti-microbiological activities of bio-synthesized silver Nano-stars by Saccharopolyspora hirsuta

“…Nanomaterials vary by size, distribution, and particle morphology (Service, 2000). Among nanometals, silver nanoparticles (AgNPs) are the most commonly used, given their range of biological activities and good chemical stability (Vennila et al, 2018, Prabhu and Poulose, 2012,). In the present work, we aimed to isolate and identify actinobacterial isolate from an insect Tapinoma simrothi.…”

Galvanic Displacement Synthesis of Monodisperse Janus‐ and Satellite‐Like Plasmonic–Magnetic Ag–Fe@Fe3O4 Heterostructures with Reduced Cytotoxicity

“…Compared with the widely studied Au‐based NPs, Ag‐based NPs are seldom used in biomedical field, except for antimicrobial, mainly due to the serious cytotoxicity of Ag + released from Ag NPs . However, the unique properties of Ag NPs, such as special optical property, excellent electrical conductivity, good catalytic ability, bactericidal ability, and so on, are promising for biomedical application except their toxicity . Thus, efforts to reduce the biotoxicity of Ag are urgent needed.…”