Comparison of blood sirolimus, tacrolimus and everolimus concentrations measured by LC-MS/MS, HPLC-UV and immunoassay methods

Comparison of Two Methods, UHPLC-UV and UHPLC-MS/MS, for the Quantification of Polyphenols in Cider Apple Juices

“…Several studies have already reported similar results without any additional explanation [18,19]. Since we compared the results obtained from simultaneous UV and MS analysis here, samples or standard preparations could not be implicated in these variations.…”

“…This time analysis is longer than that reported by Ceyman et al [17]. We chose to increase analysis time to separate all major phenolic compounds present in apple juice, especially to avoid, as much as possible, co-elutions that may affect UV and mass quantifications due to possible matrix effects already reported by other authors [18,19]. The chromatogram obtained under these conditions is available to quantify 25 additional compounds identified primarily as polymeric flavanols, subject to the availability of standards.…”

A Direct Method for the Measurement of Everolimus and Sirolimus in Whole Blood by LC–MS/MS Using an Isotopic Everolimus Internal Standard

“…[10][11][12][13] The benefits of sensitivity, specificity, and multiple reaction monitoring make liquid chromatography tandem mass spectrometry (LC-MS/MS) a useful alternative. 7,14,15 Several LC-MS/MS methods are available for the measurement of sirolimus and/or everolimus.…”

Evaluation of a LC–MS method for everolimus preclinical determination in brain by using [13C2D4]RAD001 internal standard

“…A number of works establish suitable liquid chromatography-mass spectrometry detection (LC-MS) methods, which grant accurate RAD001 dosage in clinical samples on a high throughput regime also with online purification steps [4][5][6][7][8][9][10][11]. However, biological matrix effects represent a serious pitfall in drug quantitation due to potential interferences [12].…”