Comparison of Carbon Ions Versus Protons

Weber, Uli; Kraft, Gerhard

doi:10.1097/ppo.0b013e3181b01935

Cited by 96 publications

(58 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ionizing radiation can be either high- (densely ionizing) or low-LET (sparsely ionizing). Photons are generally considered low-LET radiation with a broad distribution of dose within tissue peaking relatively near the surface [12]. Heavier charged particles can be either high- or low-LET depending on their speed.…”

Section: Rationale For Charged Particle Therapymentioning

confidence: 99%

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

Mohamad

Sishc

Saha

et al. 2017

Cancers

148

130

View full text Add to dashboard Cite

Compared to conventional photon-based external beam radiation (PhXRT), carbon ion radiotherapy (CIRT) has superior dose distribution, higher linear energy transfer (LET), and a higher relative biological effectiveness (RBE). This enhanced RBE is driven by a unique DNA damage signature characterized by clustered lesions that overwhelm the DNA repair capacity of malignant cells. These physical and radiobiological characteristics imbue heavy ions with potent tumoricidal capacity, while having the potential for simultaneously maximally sparing normal tissues. Thus, CIRT could potentially be used to treat some of the most difficult to treat tumors, including those that are hypoxic, radio-resistant, or deep-seated. Clinical data, mostly from Japan and Germany, are promising, with favorable oncologic outcomes and acceptable toxicity. In this manuscript, we review the physical and biological rationales for CIRT, with an emphasis on DNA damage and repair, as well as providing a comprehensive overview of the translational and clinical data using CIRT.

show abstract

Section: Rationale For Charged Particle Therapymentioning

confidence: 99%

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

Mohamad

Sishc

Saha

et al. 2017

Cancers

148

130

View full text Add to dashboard Cite

show abstract

“…Recently, a patient-outcome study investigated second cancer incidence after therapy with photons or protons [4], and from those data it appears that protons offer a significantly lower rate of carcinogenesis than photons. Due to the sharper physical dose gradients [47] and differential relative biological effectiveness (RBE) [12], carbon-ion therapy might provide reduced dose to normal tissues compared to proton therapy [12,18,38]. However, the capacity of high LET radiation to induce late effects is much less understood than that of low LET radiation and could increase risks of second cancer after radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Comparative Risk Predictions of Second Cancers After Carbon-Ion Therapy Versus Proton Therapy

Eley

Friedrich

Homann

et al. 2016

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

The purpose of this work was to propose a theoretical framework that enables comparative risk predictions for second cancer incidence after particle-beam therapy for different ion species for individual patients, accounting for differences in relative biological effectiveness (RBE) for the competing processes of tumor initiation and cell inactivation. Our working hypothesis was that using carbon-ion therapy instead of proton therapy would show a difference in the predicted risk of second cancer incidence in the breast for a sample of Hodgkin lymphoma (HL) patients. We generated biologic treatment plans and calculated relative predicted risks of second cancer in the breast using two proposed methods: a full model derived from the linear-quadratic model and a simpler linear-no-threshold model. For our reference calculation, we found the ratio of predicted risk of breast cancer incidence for carbon-ion versus proton plans to be 0.75±0.07 but not significantly smaller than 1 (p=0.180). Our findings suggest that second cancers risks are, on average, comparable between proton therapy and carbon-ion therapy.

show abstract

“…In comparison to the low-LET proton and photon beams, carbons are of mixed LET with low LET in the entrance channel and high LET in the target volume and therefore DNA damage is restricted to the end of their range (19). Altogether, the superior biophysical and biological profile of carbons over conventional radiotherapy enables more precise dose localization for the therapy of anatomically complex and radioresistant malignancies, sparing the normal tissues from the severe side effects of conventional radiation (20).…”

Section: Discussionmentioning

confidence: 99%

Genetic alterations after carbon ion irradiation in human lung adenocarcinoma cells

Fokas

You²,

Juricko³

et al. 2010

Int J Oncol

View full text Add to dashboard Cite

Abstract. The aim of this study was to investigate the difference in gene expression profiles of human lung adenocarcinoma cells and identify genes whose expression is altered by heavy ions but not X-rays. The lung adenocarcinoma cell line A549 was irradiated with carbon ion beams and X-rays using biologically equivalent doses (2 Gy and 6 Gy, respectively). The transcriptional profiling was determined with a high density cDNA microarray containing 11.800 genes, and genetic network and gene ontology analysis was performed. The changes in selected genes involved were validated by quantitative real-time polymerase chain reaction (qRT-PCR). The microarray analysis identified 49 mapped, network-eligible genes, the expression level of which was altered by carbon ions but not by X-rays. From these, 29 were upregulated while 20 genes were downregulated 4 h postirradiation with carbon ions in A549 cells, as compared to the control. Among these, three genes (CCND2, RARG and E2F5) were involved in the aryl hydrocarbon receptor signalling and G1/S cell cycle checkpoint pathways. The microarray data were corroborated by qRT-PCR analysis of the selected genes (p<0.05). Our findings provide information on the genetic signature of carbon ions in human lung adenocarcinoma cells and add to the understanding of the complicated molecular response to carbon ion irradiation.

show abstract

Comparison of Carbon Ions Versus Protons

Cited by 96 publications

References 14 publications

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

Comparative Risk Predictions of Second Cancers After Carbon-Ion Therapy Versus Proton Therapy

Genetic alterations after carbon ion irradiation in human lung adenocarcinoma cells

Contact Info

Product

Resources

About