Comparison of Cefuroxime Axetil and Doxycycline in the Treatment of Early Lyme Disease

Nadelman, Robert B.; Luger, Steven W.; Frank, Elliot; Wisniewski, Michael; Collins, Jeffrey J.; Wormser, Gary P.

doi:10.7326/0003-4819-117-4-273

Cited by 203 publications

(115 citation statements)

References 29 publications

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“…Physicians also gained more experience following patients who were treated with antibiotics, and, with longer periods of observation, it became apparent that these nonspecific symptoms frequently resolved without further antibiotic treatment, and that antibiotic therapy did not hasten their resolution [33,54]. Further studies also showed that symptomatic patients were not more likely to be seropositive than patients without symptoms and that patients did not develop objective manifestations of late Lyme disease [12,18].…”

Section: The Possible Causes Of Post-lyme Disease Symptomsmentioning

confidence: 99%

Chronic Lyme Disease: A Review

Marques

2008

Infectious Disease Clinics of North America

177

123

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Section: The Possible Causes Of Post-lyme Disease Symptomsmentioning

confidence: 99%

Chronic Lyme Disease: A Review

Marques

2008

Infectious Disease Clinics of North America

177

123

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“…It was shown that doxycycline, amoxicillin, and cefuroxime axetil had similar theurapeutic results in the early stages of the disease (45,46). Erythromycin and azithromycin are less effective than other oral antibiotics, which can be used as second-line treatment.…”

Section: Treatmentmentioning

confidence: 99%

Ticks, Borrelia Burgdorferi and Lyme Disease

Bağcı¹,

Ruzicka²

2016

tdd

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Lyme disease, which is caused by spirochete Borrelia burgdorferi sensu lato, is a ticktransmitted, multisystem infectious disease. It occurs in stages, with different clinical manifestations at each stage. Erythema migrans is the most frequent manifestation which occurs at the site of the tick bite. Borrelial lymphocytoma and acrodermatitis chronica atrophicans are late-stage cutaneous manifestations. Extracutaneous signs of infection most often involve the musculoskeletal, cardiovascular, and nervous systems. Serologic assays remain the mainstay of diagnosis. All stages of the disease are curable with appropriate antibiotic therapy. Keywords: Lyme disease, Borrelia burgdorferi, erythema migrans, acrodermatitis chronica atrophicans, ticks, Ixodes Işın Sinem Bağcı, Thomas Ruzicka* Ticks, Borrelia Burgdorferi and Lyme DiseaseKeneler, Borrelia Burgdorferi ve Lyme Hastalığı Öz AbstractLyme hastalığı Borrelia burgdorferi sensu lato grubu spiroketlerin sebep olduğu multisistemik bir enfeksiyon hastalığıdır. Her hastalık evresi değişik klinik bulgularla kendini gösterir. En sık klinik bulgusu kene ısırık yerinde gelişen eritema migranstır. Borrelial lenfositoma ve akrodermatitis kronika atrofikans geç dönemde gelişen deri bulgularıdır. Deri bulguları dışında kas-iskelet, kardiyovasküler ve sinir sistemi tutulumu da görülebilir. Tanı serolojik testler ile konulur. Hastalığın her evresi uygun antibiyotiklerle tedavi edilebilir.

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“…Two small studies found that doxycycline (100 mg twice-daily) and amoxicillin (500 mg three times a day, plus probenecid at the same dose), both administered for ten days in one study and for three weeks in another, had a comparable efficacy in the treatment of early localized LD [17,18]. Two other studies on the treatment of erythema migrans compared cefuroxime axetil (500 mg twice per day for 20 days) with doxycycline (100 mg 3 times per day for 20 days), demonstrating similar efficacy [19,20]. In a separate randomized trial of 43 children with erythema migrans, 2 different dosage regimens of cefuroxime axetil (20 mg/kg per day or 30 mg/kg per day) were found to have efficacy comparable to amoxicillin (50 mg/kg per day) [21].…”

Section: Introductionmentioning

confidence: 99%

Therapy of Lyme Disease

Trevisan¹,

Errichetti²,

Meo³

et al. 2016

TODJ

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Borrelia burgdorferi is highly susceptible to antibiotic treatment and the majority of patients profit from this treatment. Antibiotic selection, dose and route of administration, and duration of therapy for Lyme disease depend on the patient's clinical manifestations and stage of disease, age, pregnancy status, as well as the presence of other concomitant diseases and/or allergies. Despite an appropriate antibiotic therapy, about 10-20% of patients may show persistent or recurrent symptoms ("post-treatment Lyme disease syndrome").In the present paper we will briefly discuss the post-exposure prophylaxis, before going on to talk over the current therapeutic approach regarding the management of Lyme disease according to the stage of disease/clinical manifestations. Finally, we will discuss the main treatment-related phenomenon, the Jarisch-Herxheimer reaction, and the treatment modalities for special categories of patients, namely pregnant women, subjects suffering from post-treatment Lyme disease syndrome, possible Borrelia-associated skin manifestations, coinfections and Baggio-Yoshinary syndrome.

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Comparison of Cefuroxime Axetil and Doxycycline in the Treatment of Early Lyme Disease

Abstract: Cefuroxime axetil is well tolerated and appears to be equally as effective as doxycycline in the treating of early Lyme disease and in preventing the subsequent development of late Lyme disease.

Cited by 203 publications

References 29 publications

Chronic Lyme Disease: A Review

Chronic Lyme Disease: A Review

Ticks, Borrelia Burgdorferi and Lyme Disease

Therapy of Lyme Disease

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