Comparison of Ciprofloxacin Ophthalmic Solution 0.3% to Fortified Tobramycin-Cefazolin in Treating Bacterial Corneal Ulcers

Contact lens-associated microbial keratitis

“…In the present study, second-generation fluoroquinolones ciprofloxacin and ofloxacin and fourth-generation fluoroquinolones moxifloxacin and gatifloxacin displayed satisfactory rates of susceptibility to both gram-positive and-negative bacteria. Hyndiluk et al compared clinical response to ciprofloxacin 0.3% and tobramycin-cephazolin in cases of bacterial keratitis and found equal results (34) . Constantinou et al also found similar clinical response when comparing moxifloxacin, ofloxacin and fortified tobramycin-cephazolin in the treatment of bacterial keratitis (34) .…”

“…Hyndiluk et al compared clinical response to ciprofloxacin 0.3% and tobramycin-cephazolin in cases of bacterial keratitis and found equal results (34) . Constantinou et al also found similar clinical response when comparing moxifloxacin, ofloxacin and fortified tobramycin-cephazolin in the treatment of bacterial keratitis (34) . Fluoroquinolones are easily available commercially, since they do not require preparation, and the use of such drugs could be a good choice for initial empiric treatment for CLMK.…”

Comparison of in vitro Susceptibilities of Ocular Bacterial Isolates to Gatifloxacin and Other Topical Antibiotics

“…This may explain why in vitro antibacterial susceptibility test results do not always coincide with the clinical response [2,14,15] , although Garg et al [16] noted that their isolates of P. aeruginosa classed as resistant to ciprofl oxacin by in vitro testing also failed to respond to topical ciprofl oxacin treatment. In vitro studies with antibiotics are essential since they offer an insight into the comparative susceptibility of bacteria to different antibiotics [12] .…”

Management of bacterial keratitis: beyond exorcism towards consideration of organism and host factors

“…The fluoroquinolones have now been shown in two separate independent trials to provide a safe and effective therapy for acute bacterial keratitis when compared with combination fortified antibiotic treatment. 102,103 Penicillin-G at a concentration of 100 000 U/ml remains the initial drug of choice for keratitis caused by Streptococcal species, including S. pneumoniae. Some penicillin-resistant pneumococcal strains have recently been identified.…”