Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis

Yao, Hao; Wang, Bo; Wen, Li-Li; Jin, Qinglin; Li, Hongbo; Huang, Gang; Yin, Junqiang; Zou, Changye; Xie, Xianbiao; Shen, Jingnan

doi:10.1186/s12885-018-5062-6

Cited by 5 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, we defined radiological vascular involvement as that when MRI does not show a rim of normal tissue in the tumor/reactive area-to-vessel interface, even if any part of the main blood vessels pass through the tumor lesion or reactive area on the MRI findings [27]. The distance between the tumor lesion, reactive area and main blood vessels on the pretreatment MRI were measured as previously described [33]. We defined NBR: the shortest distance from the center of the main blood vessels to the margin of the reactive area; NBT: the shortest distance from the center of main blood vessels to the margin of tumor lesion (Figure 2).…”

Section: Methods Of Evaluationmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Significance of the Radiological Relationship between the Tumor and the main blood vessels in Enneking IIB Osteosarcoma of the extremities

et al. 2020

Self Cite

View full text Add to dashboard Cite

Aim: Osteosarcoma is one of the most prevalent primary bone malignancies in children and adolescents. Magnetic resonance imaging (MRI) has been considered a very critical tool to provide anatomical information of tumor and surrounding main blood vessels. To evaluate the prognostic significance of the radiological vascular involvement according to the pre-treatment MRI in patients with Enneking IIB osteosarcoma. Methods: In this retrospective study, we included 482 patients younger than 50 years old with Enneking IIB primary osteosarcoma of the extremities with complete clinical records from 2005 to 2015.Univariate and multivariable analyses were conducted to identify the risk factors for OS (Overall survival) and EFS (Event-free survival). The correlations between the risk factors was performed using Spearman analysis. The Kaplan-Meier method was used to calculate survival curves. Based on the radiological relationship between the tumor lesion and the surrounding reactive area with the main blood vessels as shown on pretreatment MRI findings. Results: Radiological vascular involvement assessed via pretreatment MRI is an important risk factor for Enneking IIB primary patients with osteosarcoma (HROS=2.32/HREFS=1.81 P<0.01) according to the univariate and multivariable analyses. Enneking IIB patients with osteosarcoma were assigned to three subtypes based on the radiological relationship between the main blood vessels and the lesion or reactive area. The 5-year cumulative OS of patients classified by the three types were 81.6% (type I), 67.1% (type II) and 44.8% (type III)(P<0.01). The 5-year cumulative EFS of the three types were 60.2% (type I), 46.7% (type II) and 30.2% (type III)(P<0.05). The total 5-year cumulative OS and EFS for all patients were 68.3% and 48.3%, respectively. Conclusion: Vascular involvement according to radiological findings from pretreatment MRI is an independent risk factor for cumulative OS and EFS in patients with Enneking IIB primary osteosarcoma of the extremities. The new subtyping based on the relationship between the tumors and surrounding reactive area with the main blood vessels based on pretreatment MRI can predict the prognosis of patients with osteosarcoma and provide certain directive information for selecting the appropriate surgical procedure for individual patients.

show abstract

Section: Methods Of Evaluationmentioning

confidence: 99%

“…Standard treatment of osteosarcoma involved neoadjuvant chemotherapy, surgery and adjuvant chemotherapy. Four commonly used drugs for neoadjuvant and adjuvant chemotherapy include high-dose methotrexate, cisplatin, doxorubicin, and ifosfamide, which were administered at the interval presented in Figure 1 [33].…”

Section: Study Populationmentioning

confidence: 99%

Clinical Significance of the Radiological Relationship between the Tumor and the main blood vessels in Enneking IIB Osteosarcoma of the extremities

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…A rare primary malignant tumour of the proximal peroneal bone presents a challenge for orthopaedic surgeons owing to its proximity to the biceps femoris tendon, lateral collateral ligament, common peroneal nerve and anterior tibial artery (12,13). The classic surgical modalities for the treatment of proximal fibular tumours were first reported by Malawer in 1984 (8).…”

Section: Discussionmentioning

confidence: 99%

Clinical effect of surgical resection on primary malignant and invasive bone tumours of the proximal fibula

Zhang

et al. 2023

Mol Clin Oncol

View full text Add to dashboard Cite

There is no unified surgical plan for fibular proximal malignant tumours; therefore, the present study retrospectively analysed the medical records of 19 patients with primary malignant and invasive tumours in the proximal fibula and discussed the postoperative oncological results, complications and postoperative functions of limb salvage surgery. According to pathological classification, there were 10 osteosarcoma cases, 3 chondrosarcoma cases, 2 invasive giant cell osteosarcoma tumour cases, 1 epithelioid sarcoma case, 1 leiomyosarcoma case, 1 fibrosarcoma case and 1 lymphoma case. According to the Enneking instalment, IB stage was found in 2 cases, IIA in 2 cases and IIB in 15 cases. A total of 3 patients underwent Malawer I resection, and 16 patients underwent Malawer II resection. The follow-up period was 11-174 months, with an average of 76.58 months. Local recurrence occurred in three patients and distant metastasis in seven patients; 4 patients succumbed and 15 survived. After biceps femoris tendon reconstruction and lateral collateral ligament insertion, 18 patients had good knee stability. The Musculoskeletal Tumour Society scale ranged between 23 and 29 points, with an average of 27.26 points; the Lysholm Knee Score was 65-84 points, with an average of 83 points. After the resection of proximal fibula primary and invasive tumours, the biceps femoris tendon and lateral collateral ligament insertion point was reconstructed. The data show that this technique can effectively reconstruct stability and restore knee function.

show abstract

“…All the data were obtained from the electronic clinical records, including age, sex, chief complaint, lesion site, neoplastic size, related surgery or injury history, laboratory results, surgery type, and follow-up. Tumor volumes (TVS) were calculated using Gobel's method as described previously: TVS = π/6 × (tumor length) × (tumor width) × (tumor depth) (11). The neutrophil/lymphocyte ratio (NLR) was defined as the ratio of absolute neutrophil counts divided by absolute lymphocyte counts as prognostic markers (12).…”

Section: Clinical Datamentioning

confidence: 99%

Clinical comparison of tenosynovial giant cell tumors, synovial chondromatosis, and synovial sarcoma: analysis and report of 53 cases

Wang¹,

Long²,

Wei³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

Background: Tenosynovial giant cell tumors (TGCTs), synovial chondromatosis (SC), and synovial sarcoma (SS) exhibit similarities in clinical features and histochemical characteristics, and differential diagnosis remains challenging in clinical practice.Methods: Data were collected from the pathology database of Shanghai Ninth People's Hospital regarding patients who underwent surgery from 2010 to 2019 with histologically confirmed TGCTs, SC, and SS.Demographic and clinicopathological data of these patients were reviewed. Immunohistochemistry staining of 14 different markers was performed. Correlation analyses of the prognoses were evaluated.Results: A total of 26 patients with TGCTs (8 diffuse TGCTs and 18 localized TGCTs), 16 with SC, and 11 with SS were identified. Pain was the main symptom of patients with both TGCTs and SC, while a palpable mass was the most common symptom for patients with SS. In addition to clinical features, we identified vital risk factors for disease recurrence. The mean follow-up periods were 51, 39, and 14 months for TGCTs, SC, and SS, respectively. Younger patients with diffuse TGCTs or patients with a higher neutrophil/lymphocyte ratio (NLR) displayed a significantly higher frequency of recurrence. We also plotted receiver operating characteristic (ROC) curve analysis for age and NLR. The area under the ROC curve (AUC) was calculated and demonstrated the ability to distinguish recurrent from nonrecurrent cases. In addition, higher CD163 expression was linked to recurrent diffuse TGCT cases. Conclusions: These data indicated possible characteristics of different aspects of TGCTs, SC, and SS.Further clarification and understanding of these factors will help with differential clinical diagnosis and recurrent risk assessment.

show abstract

Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis

Cited by 5 publications

References 25 publications

Clinical Significance of the Radiological Relationship between the Tumor and the main blood vessels in Enneking IIB Osteosarcoma of the extremities

Clinical Significance of the Radiological Relationship between the Tumor and the main blood vessels in Enneking IIB Osteosarcoma of the extremities

Clinical effect of surgical resection on primary malignant and invasive bone tumours of the proximal fibula

Clinical comparison of tenosynovial giant cell tumors, synovial chondromatosis, and synovial sarcoma: analysis and report of 53 cases

Contact Info

Product

Resources

About