Comparison of Clinical Manifestations in Alzheimer Disease and Dementia With Lewy Bodies

Nervi, Angela; Reitz, Christiane; Tang, Mingxin; Santana, Vincent; Piriz, Angel; Reyes‐Dumeyer, Dolly; Lantigua, Rafael; Medrano, Martin; Jiménez‐Velázquez, Ivonne Z.; Lee, Joseph H.; Mayeux, Richard

doi:10.1001/archneur.65.12.1634

Cited by 30 publications

(18 citation statements)

References 65 publications

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“…However, the age at death for pure DLB was not different from the pure AD or ADϩDLB cases in either the NACC or the UK ADC data. Further, neither our results nor other sources [30][31][32] have indicated that DLB duration of disease differs systematically from AD or ADϩDLB. Still, the possibility of a survivor bias has not been completely ruled out.…”

contrasting

confidence: 97%

Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies

Nelson¹,

Jicha²,

Abner³

et al. 2009

Neurology

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contrasting

confidence: 97%

Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies

Nelson¹,

Jicha²,

Abner³

et al. 2009

Neurology

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“…Visuospatial abilities were more impaired in the LBD cluster than the non-LBD cluster. This, together with a trend for relatively preserved memory in the LBD cluster, is consistent with findings from previous studies in patients with a clinical diagnosis of DLB [26] . Since the cognitive scores might inform the clinical diagnosis, there is a potential circularity in such findings, and thus the current results provide additional support for the hypothesis that mild DLB is associated with a characteristic cognitive profile.…”

Section: Discussionsupporting

confidence: 92%

Core and Suggestive Symptoms of Dementia with Lewy Bodies Cluster in Persons with Mild Dementia

Rongve

Brønnick

Ballard

et al. 2010

Dement Geriatr Cogn Disord

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Objectives: To explore how the core and suggestive symptoms of dementia with Lewy bodies (DLB) cluster in persons with newly diagnosed mild dementia, and whether they are associated with a particular pattern of cognitive impairment. Method: Persons with mild dementia (n = 139) were recruited from dementia clinics in western Norway. Symptoms were rated using standardized instruments. A 2-step cluster analysis was applied to classify persons into groups according to scores on scales for hallucinations, parkinsonism, fluctuations and REM sleep behaviour disorder (RBD). Result: Four distinct clusters were revealed: a ‘Lewy body dementia’ (LBD) cluster with high scores for hallucinations, parkinsonism and fluctuation, and a ‘non-LBD’ cluster with low scores on all DLB symptom scales. In addition, 2 clusters with high scores on either RBD or cognitive fluctuation scales emerged. Persons in the LBD cluster had lower scores for visuospatial cognitive abilities as compared to the non-LBD group (p = 0.002). Conclusion: Applying cluster analysis, we identified distinct subgroups in mild dementia based on symptoms such as hallucinations, parkinsonism and cognitive fluctuations. Our findings provide empirical support for diagnosing DLB. Visual hallucinations and motor parkinsonism might be the most distinguishing symptoms for DLB in mild dementia.

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“…A much more severe impairment in copying tasks is observed in early-onset AD patients and in PCA variant, in which severe constructive defects are usually associated with progressive visual-spatial disorders, including Balint syndrome and unilateral spatial neglect [100,101]. A very similar pattern of drawing impairment is found in LBD, in which visuospatial difficulties are often early and prominent and contribute to the disproportionate impairment in constructional tasks observed in these patients [151][152][153].…”

Section: Resultsmentioning

confidence: 94%

“…No 2-year decline in FTD Comparison AD-LBD Nervi [152] Figure copying LBD worse than AD Crowell [153] Figure copying LBD worse than AD Tiraboschi [154] Figure copying LBD worse than AD; no differences in pentagon copying Cahn-Wiener [156] CDT No differences in overall score, but more conceptual and planning errors in LBD Hamilton [157] Clock copying No differences, but lower scores predicted steeper decline in LBD Cagnin [158] CDT LBD worse than AD Palmqvist [159] CDT, cube copying LBD worse than AD Gnanalingham [162] CDT, clock copying No difference in CDT; LBD worse than AD in clock copying Ala [164] Pentagon copying LBD worse than AD Cormack [165] Pentagon copying LBD worse than AD Connor [166] Pentagon copying No difference Caffarra [167] Figure copying, No difference in figure copying, pentagon copying worse scores in LBD on an analytic scoring system for pentagon copying AD, Alzheimer's disease; VaD, vascular dementia; sVaD, subcortical VaD; FTD, frontotemporal dementia; bvFTD, behavioral variant of FTD; PA, progressive aphasia; LBD, Lewy body dementia; CDT, Clock drawing test; ROCF, copy of Rey's complex figure. Reference numbering follows the text.…”

Section: Drawing Disorders In Vascular Dementiamentioning

confidence: 99%

“…Visuospatial tasks, such as object size discrimination, form discrimination, overlapping figure identification, and visual counting tasks, may reveal more impaired performances in LBD than in AD, and these defects likely contribute to the disproportionate impairment in constructional tasks in LBD patients [151][152][153].…”

Section: Drawing Disorders In Lewy Body Dementiamentioning

confidence: 99%

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Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

Trojano

Gainotti

2016

JAD

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Abstract. Drawing is a multicomponential process that can be impaired by many kinds of brain lesions. Drawing disorders are very common in Alzheimer's disease and other forms of dementia, and can provide clinical information for the distinction of the different dementing diseases. In our review we started from an overview of the neural and cognitive bases of drawing, and from a recollection of the drawing tasks more frequently used for assessing individuals with dementia. Then, we analyzed drawing disorders in dementia, paying special attention to those observed in Alzheimer's disease, from the prodromal stages of the amnesic mild cognitive impairment to the stages of full-blown dementia, both in the sporadic forms with late onset in the entorhino-hippocampal structures and in those with early onset in the posterior neocortical structures. We reviewed the drawing features that could differentiate Alzheimer's disease from vascular dementia and from the most frequent forms of degenerative dementia, namely frontotemporal dementia and Lewy body disease. Finally, we examined some peculiar aspects of drawing disorders in dementia, such as perseverations, rotations, and closing-in. We argue that a careful analysis of drawing errors helps to differentiate the different forms of dementia more than overall accuracy in drawing.

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Comparison of Clinical Manifestations in Alzheimer Disease and Dementia With Lewy Bodies

Cited by 30 publications

References 65 publications

Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies

Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies

Core and Suggestive Symptoms of Dementia with Lewy Bodies Cluster in Persons with Mild Dementia

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

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