Comparison of contraceptive acceptability of levonorgestrel and ethinyl oestradiol administered in one three-phasic (Trionetta®) and one monophasic (Neovletta®) version

Multicenter study in Hungary with a 30μg ethinylestradiol- and 150μg desogestrel-containing monophasic oral contraceptive

“…The excellent cycle control is further confirmed by the very low discontinuation rate for bleeding problems (0.9%). This rate compares favorably with the discontinuation rate in studies of other oral contraceptives where discontinuation rates for bleeding problems range from 2.7% [20] to 5.3% [19]. Other factors which determine the acceptability of a contraceptive method include the occurrence of side-effects.…”

“…Acceptability is therefore greatly enhanced if an oral contraceptive provides a good cycle control. After the initial rise in cycle disturbances in the first cycle, as is commonly seen with all oral contraceptives [19][20][21][22], these irregularities settled over the ensuing cycles during treatment with Marvelon. After six cycles fewer women (6.3%) complained of irregular bleeding than before the start of treatment (6.8%), a reduction which could be seen both in starters as well as in switchers.…”

Triphasic versus monophasic oral contraceptives for contraception

“…We included 23 studies comparing triphasic oral contraceptives and monophasic oral contraceptives in this review. Six studies were published in duplicate (Carlborg 1983;Dieben 1984;Lachnit-Fixson 1984;Saxena 1992;Sulak 1999). The Characteristics of included studies has detailed information regarding participants, inclusion and exclusion criteria, study sites, duration of study, study medication and outcome measures.…”

“…Cochrane Database of Systematic Reviews 30 μg ethinylestradiol (Carlborg 1983;Chen 1987;Dunson 1993;Engebretsen 1987;Kashanian 2010;Ramos 1989;Saxena 1992;Zador 1979). Pharmaceutical companies market the triphasic preparation under the brand names Logynon, Trionetta 21 and 28, Triquilar, Trinordiol, and Triphasil.…”

Pituitary-ovarian activity when switching from various monophasic pills to a triphasic pill

“…In addition to a reduced total dose of progestogens ingested per cycle, other advantages attributed to the triphasic pill include better cycle control [3], improvement of acne [4] and low incidence of post-pill amenorrhea [5]. For these and other reasons, physicians and family planning advisers have switched, and are switching, their patients from monophaslc to triphasic pills.…”